A5046544931- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Neuroscience and Neuropharmacology Research
- Infective Endocarditis Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Eicosanoids and Hypertension Pharmacology
- Synthesis and biological activity
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Receptor Mechanisms and Signaling
- Olfactory and Sensory Function Studies
- Cardiovascular Disease and Adiposity
- Nicotinic Acetylcholine Receptors Study
- Synthesis and Biological Evaluation
- Synthesis and Reactivity of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Neurotransmitter Receptor Influence on Behavior
- Nitric Oxide and Endothelin Effects
- Cardiac electrophysiology and arrhythmias
- Circadian rhythm and melatonin
- Pharmacological Effects of Natural Compounds
- Cholinesterase and Neurodegenerative Diseases
- Neuropeptides and Animal Physiology
Ollscoil na Gaillimhe – University of Galway
2023-2025
Nagoya University
2020-2023
Iwate Medical University
2023
Nagoya University Hospital
2020-2022
Tosei General Hospital
2016-2020
Mitsubishi Group (Japan)
1976-2004
Mitsubishi Chemical (Japan)
1981-1995
Osaka University
1989
Mitsubishi Chemical (Germany)
1983-1985
There are limited head-to-head randomised trials comparing the performance of different transcatheter heart valves (THVs).
Diffuse coronary artery disease (CAD) impacts the immediate hemodynamic and clinical outcomes of percutaneous intervention (PCI). We evaluated whether diffuse pattern CAD derived from angiographic Quantitative flow ratio (QFR) outcome post-PCI medium term predicted vessel-oriented composite endpoint (VOCE). Paired pre-procedure QFRs were assessed in 503 patients 1022 vessels Multivessel TALENT (MVT) trial. The pathophysiological was defined as "predominantly diffuse" or "focal" according to...
The present study characterizes the neurochemical profile of newly synthesized compound 5-{3-[((2S)-l,4-benzodioxan-2-ylmethyl)amino]propoxy}-l,3-benzodioxole HC1 (MKC-242). In in vitro experiments, MKC-242 had high affinity for serotonin1A (5-HT1A) receptors (Ki: 0.35 nM) and moderate α1-adrenoceptors 21 nM), whereas it no appreciable any other neurotransmitter recognition sites studied 5-HT transporter. (0.3-3.0mg/kg, s.c.; 1-l0 mg/kg, p.o.) caused presynaptic 5-HT1A-receptor-mediated...
Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine (ACh) level in the cerebral cortex and hippocampus rats Mongolian gerbils were examined. In normal rats, MCI-2016 (30 mg/kg, i.p.) slightly increased ACh content cortex. Scopolamine (1 or hypoxia (95% N2 + 5% O2, 9 min) decreased pretreatment attenuated decrement rats. brain was significantly following ligation bilateral carotid arteries. this case, MCI-201 6 also level. These results suggest that improvement by behavioral...
Dabigatran is a direct thrombin inhibitor used to decrease the risk of ischemic stroke in patients with non-valvular atrial fibrillation (NVAF). Its prodrug, dabigatran etexilate (DE) often co-administrated proton pump (PPI) because its adverse effects on gastrointestinal tract. Drug-drug interactions between DE and PPIs daily clinical practice have not been fully elucidated.Changes blood concentration (DC) were investigated using dilute time test randomized, open-label, two-period crossover...
Abstract Murray law-based quantitative flow ratio (µQFR) assesses fractional reserve (FFR) in bifurcation lesions using a single angiographic view, enhancing the feasibility of analysis; however, accuracy may be compromised suboptimal projections. FFR CT is well-validated non-invasive method measuring from coronary computed tomographic angiography (CCTA). We evaluated µQFR left main (LM) bifurcations, impact optimal/suboptimal fluoroscopic view with respect to CCTA, and its diagnostic...
This study evaluated the relationship between pre-PCI pathophysiological patterns of CAD assessed by QFR, intracoronary imaging findings, and their impact on immediate physiological outcomes after PCI in 206 patients.