A5088240663- Ovarian cancer diagnosis and treatment
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Nitric Oxide and Endothelin Effects
- Endometrial and Cervical Cancer Treatments
- Acute Myocardial Infarction Research
- Uterine Myomas and Treatments
- Diabetes Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Cervical Cancer and HPV Research
- Heart Failure Treatment and Management
- Digital Radiography and Breast Imaging
- Receptor Mechanisms and Signaling
- COVID-19 and healthcare impacts
- Sarcoma Diagnosis and Treatment
- Enzyme Catalysis and Immobilization
- Parathyroid Disorders and Treatments
- Eicosanoids and Hypertension Pharmacology
- Sinusitis and nasal conditions
- PARP inhibition in cancer therapy
- COVID-19 Clinical Research Studies
- Medical Imaging and Pathology Studies
- Pharmacology and Obesity Treatment
Hokkaido University Hospital
2015-2025
Tosei General Hospital
2015-2024
Utsunomiya University
2024
Hokkaido University
2009-2022
Sapporo University
2021
Kansai Electric Power (Japan)
2019
OLVG
2019
KLE Society Hospital
2018
Sir Ganga Ram Hospital
2018
Daido University
2018
Background: Cell-free DNA (cfDNA) is present in healthy individuals but elevated those undergoing physical exertion, trauma, sepsis, and certain cancers. Maintaining cfDNA concentrations vital for immune homeostasis preventing inflammatory responses. Understanding release clearance essential using as a biomarker clinical diagnostics. We focused on the fragment size of investigated dynamics half-life, particularly 100–250 base pair fragments. Methods: Healthy, adult men (n = 5; age 40 ± 4.1...
The possibility that prostaglandin H2 is an endothelium-derived contracting factor (EDCF) was evaluated in rings of thoracic aorta spontaneously hypertensive rats (SHR). When the aortic were contracted with norepinephrine (10-7mol/l) and treated acetylcholine (10-5mol/l), a relaxant response peak after approximately 1 min contractile 7min observed. these pretreated thromboxane A2/prostaglandin receptor antagonist (ONO-3708), later clearly inhibited only sustained This completely by...
This study investigated the possible involvement of prostaglandin H2, an acetylcholine-induced endothelium-derived contracting factor in rat aorta, development abnormality vasculature diabetes. Rings thoracic aorta were prepared from control Wistar-Kyoto and STZ-induced diabetic rats to examine changes isometric tension. In 10−7 M norepinephrine-precontracted rings, acetylcholine induced relaxations, which significantly impaired rats. Inhibition thromboxane A2-prostaglandin H2 receptors with...
To examine a relation between the production of acetylcholine-induced endothelium-derived contracting factor and an increase in blood pressure, endothelium-dependent contraction relaxation were evaluated by measuring isometric tension aortic rings from spontaneously hypertensive rats Wistar-Kyoto at 5, 10, 20, 30 weeks age. In norepinephrine-precontracted rings, acetylcholine (10(-8) to 10(-5) M)-induced relaxations diminished doses 10(-6) M both strains except 5 Treatment with thromboxane...
Abstract Objective Hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitors are a new class of anti-anemia agents. We retrospectively evaluated the safety and efficacy HIF-PH in patients with heart failure (HF) complicated by anemia associated chronic kidney disase. inhibitor treatment was initiated 32 HF renal were followed up for 3 months. Results Hematocrit hemoglobin levels markedly improved months after treatment. However, NT-proBNP, which is an indicator HF, did not decrease...
The number of older people in Japan is increasing more quickly than other countries; with this aging society, the elderly patients hospitalized for acute heart failure (HF) also increasing. treatment and prognosis HF may be changing, but there are insufficient recent data, especially octogenarian patients.
Ovarian cancer is the second-most lethal gynecological malignancy and seventh-commonest cause of cancer-related death in women around world. Most ovarian patients are diagnosed at advanced stages suffer from recurrence after primary cytoreductive surgery standard first-line chemotherapy. Thus, successful management requires identification factors that contribute to progression relapse. Interleukin-34 (IL-34) a novel cytokine acts as tissue-specific ligand colony-stimulating factor-1 receptor...
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are antidiabetic agents that act on the proximal renal tubules to lower blood glucose levels by inhibiting reabsorption and promoting urinary excretion. The present study assessed long-term use of SGLT2 in older patients with diabetes.A total 117 type diabetes who were given enrolled from April 2014 March 2016.The mean age was 73.7 ± 10.0 years. During follow-up period (mean 289.3 days), there no event associated oral administration...
Dabigatran is a direct thrombin inhibitor used to decrease the risk of ischemic stroke in patients with non-valvular atrial fibrillation (NVAF). Its prodrug, dabigatran etexilate (DE) often co-administrated proton pump (PPI) because its adverse effects on gastrointestinal tract. Drug-drug interactions between DE and PPIs daily clinical practice have not been fully elucidated.Changes blood concentration (DC) were investigated using dilute time test randomized, open-label, two-period crossover...
To characterize endothelium-derived contracting factor 1 (EDCF1) released under hypoxia, vascular rings isolated from spontaneously hypertensive rat (SHR) aorta and canine coronary artery were suspended for isometric tension recording in an organ chamber filled with a Krebs-Henseleit buffer. In SHR precontracted norepinephrine (10(-7) M), severe hypoxia induced initial increase by 36.7 +/- 7.5% followed 56.9 5.7% relaxation; moderate only sustained 20.6 2.5%. Inhibition of nitric oxide (NO)...
It is known that once heart failure occurs in older patients with diabetes, the overall prognosis extremely poor. We investigated whether early initiation of SGLT2 inhibitor therapy after admission was beneficial for diabetic requiring inpatient treatment acute failure.We retrospectively assessed consecutive comorbid diabetes who were admitted to Department Cardiology Tosei General Hospital failure. Patients divided into two groups: those initiated (SGLT2 group; mean age: 73 ± 9 years) and...
Objective To investigate the possible involvement of prostaglandin H2, an endothelium-derived contracting factor in rat aorta, development contraction induced by endothelin-1 Methods The aortic rings from spontaneously hypertensive rats (SHR) were prepared, and changes isometric tension these developed recorded with or without treatment several inhibitors antagonist. concentrations prostaglandins thromboxane B2 bath solution contracted measured radioimmunoassay. effects a A2/prostaglandin H2...
The aim of this review is to address the current status adjuvant chemotherapy alone in early-stage cervical cancer treatments literature. At present, therapeutic effect after radical surgery (RS) has not yet been established, and radiation therapy (RT) or concurrent chemoradiotherapy (CCRT) recommended as standard RS for various guidelines. main purpose RS, however, should be reduce extrapelvic recurrence rather than local recurrence, although RT CCRT survival benefits patients with...