A5023070033- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Cancer Genomics and Diagnostics
- Electrocatalysts for Energy Conversion
- Hippo pathway signaling and YAP/TAZ
- Colorectal and Anal Carcinomas
- Monoclonal and Polyclonal Antibodies Research
- Endometriosis Research and Treatment
- Cancer Risks and Factors
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Sarcoma Diagnosis and Treatment
- Conducting polymers and applications
- Electrodeposition and Electroless Coatings
- Cancer, Lipids, and Metabolism
- Fuel Cells and Related Materials
- Intermetallics and Advanced Alloy Properties
- Radioactive element chemistry and processing
- Advanced materials and composites
Hokkaido University
2013-2023
Hokkaido University Hospital
2014-2023
Daido University
2017-2019
Hakodate Central General Hospital
2019
The University of Texas MD Anderson Cancer Center
2017
Japan Cancer Society
2015
Astellas Pharma (Japan)
2008-2010
National Hospital Organization Hokkaido Medical Center
2008
Sapporo City General Hospital
2007
Infrafrontier
2006
// Yosuke Konno 1,* , Peixin Dong 2,* Ying Xiong 3,* Fumihiko Suzuki 4,* Jiabin Lu 5 Muyan Cai Hidemichi Watari 1 Takashi Mitamura Masayoshi Hosaka Sharon J. B. Hanley 2 Masataka Kudo and Noriaki Sakuragi 1,2 Department of Gynecology, Hokkaido University, Sapporo, Japan Women's Health Educational System, 3 State Key Laboratory Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China 4 Obstetrics Tohoku Sendai, Pathology, * These authors contributed equally to...
Ovarian cancer is one of the most aggressive female reproductive tract tumors. Paclitaxel (PTX) widely used for treatment ovarian cancer. However, cancers often acquire chemotherapeutic resistance to this agent. We investigated mechanism chemoresistance by analysis microRNAs using cell line KFr13 and its PTX-resistant derivative (KFr13Tx). found that miR-31 was downregulated in KFr13Tx cells, re-introduction miR31 re-sensitized them PTX both vitro vivo. bind 3'-UTR mRNA MET, decrease MET...
We aimed to investigate whether MIR31 is an oncogene in human endometrial cancer and identify the target molecules associated with malignant phenotype. investigated growth potentials of MIR31-overexpressing HEC-50B cells vitro vivo. In order molecule MIR31, a luciferase reporter assay was performed, corresponding downstream signaling pathway examined using immunohistochemistry tissues. also expression 34 patients according postoperative risk recurrence. The overexpression significantly...
Few studies on the prognosticators of patients with recurrent endometrial cancer after relapse have been reported in literature. The aim this study was to determine who underwent primary complete cytoreductive surgery and adjuvant chemotherapy.Thirty-five were included retrospective analysis. prognostic significance several clinicopathological factors including histologic type, risk for recurrence, time surgery, number sites, site relapse, treatment modality, resection tumors evaluated....
Abstract Background and Objectives The aim of this study was to compare the clinical efficacy paclitaxel/cisplatin (TP) as an adjuvant chemotherapy radiotherapy (RT) after radical hysterectomy systematic lymphadenectomy for patients with cervical cancer. Methods A total 125 early‐stage cancer, who underwent hysterectomy, received therapy due recurrent risk factors were retrospectively analyzed. Forty‐nine treated RT, 32 three six cycles at 4‐week interval. Survival postoperative...
According to the International Federation of Gynecology and Obstetrics staging, some surgeons perform lymphadenectomy in all patients with early stage endometrial cancer enable accurate staging. However, there are risks such as lower limb lymphedema. The aim this study was investigate whether preoperative assessment is useful select whom can be safely omitted.We evaluated risk lymph node metastasis (LNM) using LNM score (histological grade, tumor volume measured magnetic resonance imaging...
Abstract Background Clusterin is a cytoprotective chaperone protein involved in numerous physiological processes, carcinogenesis, tumor growth and tissue remodelling. The purpose of this study was to investigate whether clusterin (CLU), an antiapoptotic molecule, could be potential predictor molecule for ovarian cancer or not targeting can improve survival patients. Methods expression compared between ten primary their recurrent tumors from same patients immunohistochemically. We analyzed...
The aim of this study was to investigate the prognostic factors and treatment outcome patients with adenocarcinoma uterine cervix who underwent radical hysterectomy systematic lymphadenectomy.A total 130 stage IB IIB cervical treated lymphadenectomy from 1982 2005 were retrospectively analyzed. Clinicopathological data including age, stage, tumor size, number positive node sites, lymphovascular space invasion, parametrial deep stromal invasion (>2/3 thickness), corpus vaginal infiltration,...
// Zeinab Mohamed 1, 2, * , Kamel Hassan 3, 4, Safwat Okasha 1 Takashi Mitamura 2 Sarah Keshk 4 Yusuke Konno Tatsuya Kato Sherif F. EL-Khamisy 5 Ohba 6 and Hidemichi Watari Zoology Department, Faculty of Science, Aswan University, Aswan, Egypt Department Obstetrics Gynaecology, Hokkaido University Graduate School Medicine, Sapporo, Japan 3 Bitechnology Program, Port Said Said, Centre for Genomics, HelmyInstitute Medical Sciences, Zewail City Science Technology, Giza, Krebs Sheffield...
MicroRNAs(miRNAs) have been reported to regulate the development of chemoresistance in many tumors.Stathmin 1 (STMN1) is a microtubule-depolymerizing molecule, involved chemo-response; however, mechanism its regulation unknown.Herein, immunohistochemical study indicated significant upregulation STMN1 ovarian cancer tissues defined as resistant tumors compared with those responsive tumors.STMN1 level elevated chemoresistant cells, KF-TX, parental, KF, ones.Targeting by siRNA restored...
<h3>Importance</h3> The role of surgery in early-stage cervical cancer has been established, but it is controversial locally advanced cancer. <h3>Objective</h3> To determine whether a radical hysterectomy method with extended removal paracervical tissue for associated satisfactory oncological outcomes. <h3>Design, Setting, and Participants</h3> This retrospective cohort study was conducted from January 1, 2002, to December 31, 2011, participants were patients at single tertiary center...
Comprehensive cancer genomic profiling has been used recently for patients with advanced solid cancers. Two tests no standard treatment are covered by Japanese public health insurance since June 2019.We prospectively analyzed data of 189 cancers who underwent either the two-cancer at Hokkaido University Hospital and its liaison hospitals whose results were discussed in molecular tumor board between August 2019 July 2020.All had appropriate results. Actionable gene alterations identified 93...
Abstract Background and Objectives The aim of this study was to analyze the stage migration survival endometrial cancer by revised FIGO 2008 staging system compared with 1988 system. Methods A total 355 patients cancer, who underwent complete surgical staging, were enrolled. We stages those Results resulted in an increase I decrease II IIIa patients. 5‐year overall (OS) rates for IA IB disease 98.2% 91.9%, respectively ( P = 0.004). Five‐year OS rate new (82.6%) significantly worse than that...
Abstract Comprehensive genomic profiling (CGP) tests have been covered by public insurance in Japan for patients with advanced solid tumors who completed or are completing standard treatments do not them. Therefore, genotype‐matched drug candidates often unapproved off‐label, and improving clinical trial access is critical, involving the appropriate timing of CGP tests. To address this issue, we analyzed previous treatment data 441 from an observational study on discussed expert panel at...
We investigated the survival and failure pattern of 288 patients with endometrial cancer treated extensive surgery including systematic pelvic para-aortic lymphadenectomy followed by cisplatin-based chemotherapy from 1982 to 2002. correlated various clinicopathologic factors find predictors recurrence sites. The 5-year overall rates were 97.5% for stage I, 87.5% II, 85.2% III, 12.5% IV. Notably, rate was 76.5% IIIC disease. Among a low risk (n = 92) who received no adjuvant chemotherapy, 2...
Fluorocarbon films obtained in plasma-enhanced chemical vapor deposition with a C4F8 compound were composed of carbon cross-linked network and unlinked species encapsulated the [J. Appl. Phys. 89, 893 (2001)]. The effectively removed from films. Then, probably containing pore was extracted on wafers when dipped into tetrahydrofran (THF) solvent. fact implied that fluorocarbon porous low-dielectric constant might be formed by using dry wet processes. In present study, x-ray analyses showed...
FK506 (Tacrolimus) is a potent immunosuppressive agent and its ointment formulation was shown to be effective on atopic dermatitis in clinical study. As atrophy of the skin one adverse effects dermal application such drugs as glucocorticoid ointment, aim present study investigate whether induces rats. 0.3% treatment did not induce at site when applied daily for 3 weeks In contrast, ointments 0.05% clobetasol 17-propionate (CP: Dermovate®), 0.12% betamethasone 17-valerate (BV; Rinderon®-V),...