A5000601430- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Virology and Viral Diseases
- Viral gastroenteritis research and epidemiology
- Vector-Borne Animal Diseases
- Animal Virus Infections Studies
- MicroRNA in disease regulation
- Clusterin in disease pathology
- Hippo pathway signaling and YAP/TAZ
- Circular RNAs in diseases
- Viral Infections and Vectors
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Herpesvirus Infections and Treatments
- Kruppel-like factors research
- Virus-based gene therapy research
- Biomarkers in Disease Mechanisms
- Cancer therapeutics and mechanisms
- Viral Infections and Immunology Research
- Venomous Animal Envenomation and Studies
- Immune Response and Inflammation
- Cancer Mechanisms and Therapy
- Histone Deacetylase Inhibitors Research
- Immunotherapy and Immune Responses
Tunbridge Wells Hospital
2024
Cairo University
2024
Maidstone and Tunbridge Wells NHS Trust
2024
Zewail City of Science and Technology
2015-2024
Port Said University
2015-2024
Agricultural Research Center
2021
PRG S&Tech (South Korea)
2021
Ain Shams University
2020
Ministry of Health
2019
Hokkaido University
2008-2018
Ovarian cancer is one of the most aggressive female reproductive tract tumors. Paclitaxel (PTX) widely used for treatment ovarian cancer. However, cancers often acquire chemotherapeutic resistance to this agent. We investigated mechanism chemoresistance by analysis microRNAs using cell line KFr13 and its PTX-resistant derivative (KFr13Tx). found that miR-31 was downregulated in KFr13Tx cells, re-introduction miR31 re-sensitized them PTX both vitro vivo. bind 3'-UTR mRNA MET, decrease MET...
We isolated highly pathogenic avian influenza virus (H5N8) of clade 2.3.4.4 from the common coot (Fulica atra) in Egypt, documenting its introduction into Africa through migratory birds. This has a close genetic relationship with subtype H5N8 viruses circulating Europe. Enhanced surveillance to detect newly emerging is warranted.
This paper describes the first threats of H5N1 avian influenza outbreaks in Egypt recorded from February to December 2006 commercial and domestic poultry different species summarizes major characteristics outbreak. There were 1024 cases (rural chickens breeding types, turkeys, ducks, geese, quail) either or backyards locations Egypt. All tested positive for subtype. From these only 12 A viruses isolated characterized samples collected during outbreaks. isolates characterized, data confirmed...
Scorpions constitute a charismatic lineage of arthropods and comprise more than 2500 described species. Found throughout various tropical temperate habitats, these predatory arachnids have long evolutionary history, with fossil record that began in the Silurian. While all scorpions are venomous, asymmetrically diverse family Buthidae harbors nearly half diversity extant scorpions, but one 58 species medically significant to humans. However, lack densely sampled scorpion phylogeny has...
Abstract Background The endemic H5N1 high pathogenicity avian influenza virus (A/H5N1) in poultry Egypt continues to cause heavy losses and poses a significant threat human health. Methods Here we describe results of A/H5N1 surveillance domestic 2009 wild birds 2009–2010. Tracheal cloacal swabs were collected from 22024 commercial farms, 1435 backyards 944 live bird markets (LBMs) as well 1297 representing 28 different types migratory birds. Viral RNA was extracted mix tracheal media. Matrix...
We aimed to investigate whether MIR31 is an oncogene in human endometrial cancer and identify the target molecules associated with malignant phenotype. investigated growth potentials of MIR31-overexpressing HEC-50B cells vitro vivo. In order molecule MIR31, a luciferase reporter assay was performed, corresponding downstream signaling pathway examined using immunohistochemistry tissues. also expression 34 patients according postoperative risk recurrence. The overexpression significantly...
A series of bis -thiazoles 5a–g were synthesized from -thiosemicarbazone 3 with hydrazonoyl chlorides 4a–g. Reaction two equivalents α-halocarbonyl compounds 6–8, 10, and 12a–d afforded the corresponding -thiazolidines 9, 11, 13a–d, respectively. Condensation -thiazolidin-4-one 9 different aromatic aldehydes furnished -thiazolidin-4-ones 14a–d. Compounds 5a–g, 13a,c,d screened in vitro for their cytotoxic activities a panel cancer cell lines. 5a–c, 5f–g, exhibited remarkable activities,...
The Eurasian-lineage H5N1 highly pathogenic avian influenza (HPAI) virus caused widespread outbreaks in Egypt 2006 and eventually become enzootic poultry. Although have a seasonal pattern, with most occurring during the cooler winter months, it remains unclear whether this seasonality reflects maintenance within or yearly introductions of into country. To evaluate epidemiology HPAI Egypt, sequence analysis hemagglutinin (HA) neuraminidase (NA) genes selected Egyptian isolates from early to...
Highly pathogenic avian influenza (HPAI) H5N1 and H5N8 have become endemic among domestic poultry in Egypt since 2006 2016, respectively. In parallel, the low H9N2 virus has been 2010. Despite continuous circulation of these subtypes for several years, no natural reassortant detected so far population Egypt. this study, HPAI (H5N2) was isolated from a commercial duck farm, giving evidence emergence first reassortment event The derived as result genetic between viruses circulating exchange...
Abstract Background Clusterin is a cytoprotective chaperone protein involved in numerous physiological processes, carcinogenesis, tumor growth and tissue remodelling. The purpose of this study was to investigate whether clusterin (CLU), an antiapoptotic molecule, could be potential predictor molecule for ovarian cancer or not targeting can improve survival patients. Methods expression compared between ten primary their recurrent tumors from same patients immunohistochemically. We analyzed...
The effectiveness of recombinant turkey herpesvirus avian influenza (A/swan/Hungary/4999/2006(H5N1)) clade 2.2 virus (rHVT-H5) vaccine was evaluated in two layer chicken breeds (White Bovans [WB] and Brown Shaver [BS]). One dose rHVT-H5 administered at day 1 birds were monitored serologically (haemagglutination inhibition test) virologically for 19 weeks. Maternally-derived antibody post-vaccination H5 titres measured using the Chinese (A/Goose/Guangdong/1/96(H5N1)) HA Egyptian...
// Zeinab Mohamed 1, 2, * , Kamel Hassan 3, 4, Safwat Okasha 1 Takashi Mitamura 2 Sarah Keshk 4 Yusuke Konno Tatsuya Kato Sherif F. EL-Khamisy 5 Ohba 6 and Hidemichi Watari Zoology Department, Faculty of Science, Aswan University, Aswan, Egypt Department Obstetrics Gynaecology, Hokkaido University Graduate School Medicine, Sapporo, Japan 3 Bitechnology Program, Port Said Said, Centre for Genomics, HelmyInstitute Medical Sciences, Zewail City Science Technology, Giza, Krebs Sheffield...