A5087116077- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Animal Virus Infections Studies
- Virology and Viral Diseases
- Respiratory viral infections research
- Plant Virus Research Studies
- COVID-19 epidemiological studies
- Zoonotic diseases and public health
- Immune Response and Inflammation
- Genomics and Phylogenetic Studies
- interferon and immune responses
- Herpesvirus Infections and Treatments
- RNA and protein synthesis mechanisms
- Nuclear reactor physics and engineering
- Atomic and Subatomic Physics Research
- Oil and Gas Production Techniques
- Vibrio bacteria research studies
- Abdominal Surgery and Complications
- vaccines and immunoinformatics approaches
- Syphilis Diagnosis and Treatment
- Viral Infections and Immunology Research
- Drilling and Well Engineering
- Nuclear Physics and Applications
Uppsala University
2018-2024
University of Liverpool
2024
Agricultural Research Center
2018-2023
Friedrich-Loeffler-Institut
2015-2018
Central Laboratory For Agricultural Expert Systems
2017
We isolated highly pathogenic avian influenza virus (H5N8) of clade 2.3.4.4 from the common coot (Fulica atra) in Egypt, documenting its introduction into Africa through migratory birds. This has a close genetic relationship with subtype H5N8 viruses circulating Europe. Enhanced surveillance to detect newly emerging is warranted.
Significance In 2016/2017, highly pathogenic avian influenza (HPAI) virus of the subtype H5 spilled over into wild birds and caused largest known HPAI epidemic in Europe, affecting poultry birds. During its spread, frequently exchanged genetic material (reassortment) with cocirculating low-pathogenic viruses. To determine where when these reassortments occurred, we analyzed Eurasian viruses identified a large set reassortants. We found that new likely came from across their migratory range...
A distinct cluster of highly pathogenic avian influenza viruses subtype A(H5N1) has been found to emerge within clade 2.2.1.2 in poultry Egypt since summer 2014 and appears have quickly become predominant. Viruses this may be associated with increased incidence human infections over the last months.
We investigated in a unique setup of animal models and human lung explant culture biological properties, including zoonotic potential, representative 2016 highly pathogenic avian influenza virus (HPAIV) H5N8, clade 2.3.4.4 group B (H5N8B), that spread rapidly huge ongoing outbreak series Europe caused high mortality waterfowl domestic birds. HPAIV H5N8B showed increased virulence with rapid onset severe disease Pekin ducks due to pronounced neuro- hepatotropism. Cross-species infection was...
Wild migratory birds have the capability to spread avian influenza virus (AIV) over long distances as well transmit domestic birds. In this study, swab and tissue samples were obtained from 190 during close surveillance in Egypt response recent outbreaks of highly pathogenic (HPAI) H5N1 virus. The collected tested for a variety AIV subtypes (H5N1, H9N2, H5N8, H6N2) other pathogens such NDV, IBV, ILT, IBDV, WNV. Among all samples, HPAI was found six samples; be negative pathogens. Egyptian...
Live and wet markets (LWMs) form an important pillar of food supply in Asian countries, but the close interaction animals humans at creates interface for disease transmission. The zoonotic risks associated with LWMs were highlighted after onset COVID-19 pandemic. This study aimed to investigate risk mosquito-borne transmission LWMs, through analyzing mosquito species composition prevalence flaviviruses, as well general perception diseases Lao PDR. Adult mosquito- larval samples collected...
Widespread prevalence of avian influenza H9N2 subtype in the Middle East region and its detection Egypt quail early summer 2011 added another risk factor to Egyptian poultry industry addition highly pathogenic H5N1 subtype. This situation increases need for further surveillance investigation viruses commercial household chickens. work describes genetic characterization recently isolated from chicken flocks. Parallel infections has also been done compare two subtypes close geographic...
Highly pathogenic avian influenza (HPAI) H5N1 and H5N8 have become endemic among domestic poultry in Egypt since 2006 2016, respectively. In parallel, the low H9N2 virus has been 2010. Despite continuous circulation of these subtypes for several years, no natural reassortant detected so far population Egypt. this study, HPAI (H5N2) was isolated from a commercial duck farm, giving evidence emergence first reassortment event The derived as result genetic between viruses circulating exchange...
Highly pathogenic avian influenza viruses (HPAIVs) of subtype H5N1 have continued to perpetuate with divergent genetic variants in poultry within Asia since 2003. Further dissemination Asian-derived H5 HPAIVs Europe, Africa and, most recently, the North American continent has occurred. We report an outbreak HPAIV among falcons kept for hunting and other wild bird species bred as falcon prey Dubai, United Arab Emirates, during autumn 2014. The causative agent was identified virus H5N1, clade...
Controlling avian influenza viruses (AIVs) is mainly based on culling of the infected bird flocks or via implementation inactivated vaccines in countries where AIVs are considered to be endemic. Over last decade, several virus subtypes, including highly pathogenic (HPAI) H5N1 clade 2.2.1.2, H5N8 2.3.4.4b and recent 2.3.4.4b, have been reported among poultry populations Egypt. This demanded utilization a nationwide routine vaccination program sector. Antigenic differences between available...
ABSTRACT The cocirculation of zoonotic highly pathogenic avian influenza virus (HPAIV) subtype H5N1 and (AIV) H9N2 among poultry in Egypt for at least 6 years should render that country a hypothetical hot spot the emergence reassortant, phenotypically altered viruses, yet no reassortants have been detected Egypt. present investigations proved Egyptian clade 2.2.1.2 G1-B lineage can be generated by coamplification embryonated chicken eggs. Reassortants were restricted to acquired between two...
Emerging and re-emerging zoonoses constitute major threats to human health cause considerable socioeconomic problems globally. More than 60% of emerging infectious diseases are zoonotic most (72%) originate in wildlife.1Jones KE Patel NG Levy MA et al.Global trends diseases.Nature. 2008; 451: 990-993Crossref PubMed Scopus (4936) Google Scholar Zoonotic microbes, with the capacity for human-to-human transmission, have greatest pandemic potential.2Holmes EC Rambaut A Andersen KG Pandemics:...
The highly pathogenic avian influenza (HPAI) H5N8 virus was first detected in Egypt late 2016. Since then, the has spread rapidly among different poultry sectors, becoming dominant HPAI H5 subtype reported Egypt. Different genotypes of were Egypt; however, geographic patterns and molecular evolution Egyptian viruses are still unclear. Here, extensive epidemiological surveillance conducted, including more than half a million samples collected from sectors (farms/backyards/live bird markets)...
Since November 2016, Europe witnesses another wave of incursion highly pathogenic avian influenza (HPAI) A(H5) viruses the Asian origin goose/Guangdong (gs/GD) lineage. Infections with H5 clade 2.3.4.4b affect wild bird and poultry populations. clades 2.2, 2.3.1.2c 2.3.4.4a were detected previously in 2006, 2010 2014. Clades 2.2.1.2 2.3.2.1.c are endemic Egypt Western Africa, respectively have caused human fatalities. Evidence exists their co-circulation Middle East. Subtype low...