A5043687535- Influenza Virus Research Studies
- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- Antibiotic Use and Resistance
- Orthopaedic implants and arthroplasty
- COVID-19 Clinical Research Studies
- Microbial infections and disease research
- Viral gastroenteritis research and epidemiology
- Bacteriophages and microbial interactions
- Antibiotics Pharmacokinetics and Efficacy
- Orthopedic Infections and Treatments
- interferon and immune responses
- Zoonotic diseases and public health
- COVID-19 epidemiological studies
- Mosquito-borne diseases and control
- Animal Virus Infections Studies
- SARS-CoV-2 detection and testing
- RNA and protein synthesis mechanisms
- Bone Tissue Engineering Materials
Uppsala University
2016-2025
Uppsala University Hospital
2009-2024
Human coronaviruses continue to pose a threat human health. The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019 which causes disease-2019 (COVID-19), an disease marked the third introduction highly pathogenic into population twenty-first century. This recent previously unknown China leads huge impacts on humans globally. Covid-19 is challenge global public Here, we discuss COVID-19 outbreak one health context, highlighting need for implementation...
The ongoing SARS-CoV-2 pandemic is a global public health emergency posing high burden on nations' care systems and economies. Despite the great effort put in development of vaccines specific treatments, no prophylaxis or effective therapeutics are currently available. Nitric oxide (NO) broad-spectrum antimicrobial potent vasodilator that has proved to be reducing SARS-CoV replication hypoxia patients with severe acute respiratory syndrome. Given potential NO as treatment for infection, we...
ESBL-producing bacteria are present in wildlife and the environment might serve as a resistance reservoir. Wild gulls have been described frequent carriers of E. coli strains with genotypic characteristics similar to found humans. Therefore, potential dissemination antibiotic genes between human population need be further investigated. Occurrence characterization Swedish wild were assessed compared isolates from humans, livestock surface water collected same country time-period. is about...
The concentration of eleven antibiotics (trimethoprim, oxytetracycline, ciprofloxacin, azithromycin, cefotaxime, doxycycline, sulfamethoxazole, erythromycin, clarithromycin, ofloxacin, norfloxacin), three decongestants (naphazoline, oxymetazoline, xylometazoline) and the antiviral drug oseltamivir's active metabolite, oseltamivir carboxylate (OC), were measured weekly at 21 locations within River Thames catchment in England during month November 2009, autumnal peak influenza A[H1N1]pdm09...
Antibiotic-resistant bacteria pose challenges to healthcare delivery systems globally; however, limited information is available regarding the prevalence and spread of such in environment. The aim this study was compare antibiotic-resistant large-bodied gulls (Larus spp.) at urban remote locations Southcentral Alaska gain inference into association between antibiotic resistance wildlife anthropogenically influenced habitats.Escherichia coli cultured (n=115 isolates) from fecal samples...
Oseltamivir (Tamiflu®) is the most important antiviral drug available and a cornerstone in defence against future influenza pandemic. Recent publications have shown that active metabolite, oseltamivir carboxylate (OC), not degraded sewage treatment plants also persistent aquatic environments. This implies OC will be present environments areas where prescribed to patients for therapeutic use. The country used Japan, it treat seasonal flu. We measured levels of water samples from Yodo River...
Dear Editor, Patients infected with SARS-CoV-2 requiring intensive care due to coronavirus disease 2019 (COVID-19) frequently develop acute kidney injury (AKI) [1], but the underlying mechanisms are poorly explored.SARS-CoV-2 has been found in both urine and kidneys, where it suggested cause proximal tubule damage [2-4].Direct renal infection of causing AKI potentially leads viral shedding urine.However, our knowledge, no study undertaken investigate urinary levels patients AKI.In this...
The foodborne pathogen Yersinia enterocolitica causes gastrointestinal infections worldwide. In the spring of 2019, Swedish Public Health Agency and Statens Serum Institut in Denmark independently identified an outbreak caused by 4/O:3 that after sequence comparison turned out to be a cross-border outbreak. A trace-back investigation suggested shipments fresh prewashed spinach from Italy as common source for Here, we determined genome sequences five Y. clinical isolates during using...
Abstract The spread of virus via the blood stream has been suggested to contribute extra-pulmonary organ failure in Coronavirus disease 2019 (COVID-19). We assessed SARS-CoV-2 RNAemia (RNAemia) and association between inflammation, mortality critically ill COVID-19 patients. included all patients with PCR verified consent admitted ICU. RNA copies above 1000/ml measured by plasma was defined as used surrogate for viremia. In this cohort 92 59 (64%) were invasively ventilated. found 31 (34%)....
Bladder urothelial carcinoma (BLCA) is the 10th most common cancer with a low survival rate and strong male bias. We studied field cancerization in BLCA using multi-sample- multi-tissue-per-patient protocol for sensitive detection of autosomal post-zygotic chromosomal alterations loss chromosome Y (LOY). analysed 277 samples histologically normal urothelium, 145 tumors 63 blood from 52 males 15 females, in-house adapted Mosaic Chromosomal Alterations (MoChA) pipeline. This approach allows...
Introduction. The global spread of extended-spectrum cephalosporinase-producing Escherichia coli (producing β -lactamase or plasmid-borne AmpC, hereafter ESC-Ec) is a major public health concern. Whilst extensively studied in high-income countries, the transmission pathways between humans and animals low- middle-income countries (LMICs) remain unclear. In rural Cambodia, asymptomatic carriage dynamics ESC-Ec living close proximity are poorly understood, highlighting need for targeted...
Oseltamivir (Tamiflu®) is the most widely used drug against influenza infections and extensively stockpiled worldwide as part of pandemic preparedness plans. However, resistance a growing problem in 2008-2009, seasonal human A/H1N1 virus strains parts world carried mutation H274Y neuraminidase gene which causes to drug. The active metabolite oseltamivir, oseltamivir carboxylate (OC), poorly degraded sewage treatment plants surface water has been detected aquatic environments where natural...
Abstract Objectives This study investigates the frequency and characteristics of carbapenemase‐producing Escherichia coli/Klebsiella pneumoniae (CPE/K) extended‐spectrum cephalosporinase‐producing E. coli/K. (ESCE/K) in healthy humans livestock rural Cambodia. Additionally, household practices as risk factors for faecal carriage ESCE/K are identified. Methods Faecal samples were obtained from 307 285 including large ruminants, pigs poultry living 100 households Cambodia 2011. Each was...
Abstract Objectives To define characteristics of Klebsiella pneumoniae complex (hereafter KP) isolates from healthy pigs, farm workers and their household members in Thailand. Methods A total 839 individual rectal swabs pigs on 164 farms 271 faecal samples humans working pig persons living the same Khon Kaen, Thailand were screened for gut colonization by KP. Genomic sequences investigated antibiotic resistance virulence genes. Phylogenetic analyses performed addition to comparison with...
Antiviral provision remains the focus of many pandemic preparedness plans, however, there is considerable uncertainty regarding antiviral compliance rates. Here we employ a waste water epidemiology approach to estimate oseltamivir (Tamiflu®) compliance. Oseltamivir carboxylate (oseltamivir's active metabolite) was recovered from two treatment plant (WWTP) catchments within United Kingdom at peak autumnal wave 2009 Influenza A (H1N1)pdm09 pandemic. Predictions consumption detected levels were...
Coronaviruses (CoVs) are found in a wide variety of wild and domestic animals, constitute risk for zoonotic emerging infectious disease. In poultry, the genetic diversity, evolution, distribution taxonomy some coronaviruses have been well described, but little is known about features CoVs birds. this study we screened 764 samples from 22 avian species orders Anseriformes Charadriiformes Sweden collected 2006/2007 CoV, with an overall CoV prevalence 18.7%, which higher than many other bird...
Colistin (polymyxin E) is widely used in animal and human medicine increasingly as one of the last-resort antibiotics against Gram-negative bacilli. Due to increased use colistin treating infections caused by multidrug-resistant bacteria, resistance this antibiotic ought be monitored. The study was undertaken elucidate molecular mechanisms, genetic relationships phenotype correlations colistin-resistant isolates. Here, we report detection mcr-1 gene chicken-associated Salmonella isolates...
Abstract Background The COVID-19 pandemic, which has a prominent social and economic impact worldwide, shows largely unexplained male bias for the severity mortality of disease. Loss chromosome Y (LOY) is risk factor candidate in due to its prior association with many chronic age-related diseases, on immune gene transcription. Methods Publicly available scRNA-seq data PBMC samples derived from patients critically ill were reanalyzed, LOY status was added annotated cells. We further studied...