A5021882409- Radiopharmaceutical Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advanced Drug Delivery Systems
- Medical Imaging and Pathology Studies
- RNA Interference and Gene Delivery
- Nonlinear Dynamics and Pattern Formation
- Orthopaedic implants and arthroplasty
- Crystallography and molecular interactions
- Lipid Membrane Structure and Behavior
- Graphene and Nanomaterials Applications
- Monoclonal and Polyclonal Antibodies Research
- Curcumin's Biomedical Applications
- Orthopedic Infections and Treatments
- Enzyme Catalysis and Immobilization
- Flavonoids in Medical Research
- Chaos control and synchronization
- Nanoplatforms for cancer theranostics
- Quantum chaos and dynamical systems
- Peptidase Inhibition and Analysis
- Polyamine Metabolism and Applications
- Natural product bioactivities and synthesis
- Amino Acid Enzymes and Metabolism
- Antibiotic Resistance in Bacteria
Indian Institute of Chemical Biology
2013-2023
Noakhali Science and Technology University
2023
Bangladesh Agricultural Research Institute
2020-2022
In-Q-Tel
2011-2012
Banaras Hindu University
2002-2012
Council of Scientific and Industrial Research
2006
Jadavpur University
1988-2001
Garcinol (GAR) is a naturally occurring polyisoprenylated phenolic compound. It has been recently investigated for its biological activities such as antioxidant, anti-inflammatory, anti ulcer, and antiproliferative effect on wide range of human cancer cell lines. Though the outcomes are very promising, extreme insolubility in water remains main obstacle clinical application. Herein we report formulation GAR entrapped PLGA nanoparticles by nanoprecipitation method using vitamin E TPGS an...
The effect of nonadiabaticity dust charge variation arising due to small nonzero values ${\ensuremath{\tau}}_{\mathrm{ch}}/{\ensuremath{\tau}}_{d}$ has been studied where ${\ensuremath{\tau}}_{\mathrm{ch}}$ and ${\ensuremath{\tau}}_{d}$ are the charging hydrodynamical time scales on nonlinear propagation acoustic waves. Analytical investigation shows that a amplitude wave is governed by Korteweg--de Vries (KdV) Burger equation. Notwithstanding soliton decay, ``soliton mass'' conserved, but...
Current therapies are insufficient to prevent recurrent fungal infection especially in the lower part of lung. A careful and systematic understanding properties nanoparticles plays a significant role design, development, optimization, vivo performances nanoparticles. In present study, PLGA containing antifungal drug voriconazole was prepared two best formulations were selected for further characterization studies. The free radiolabeled with technetium-99m 90% labeling efficiency, particles...
Aim: Chitosan-coated polylactic-co-glycolic acid nanoparticles of voriconazole (VChNP) were developed to increase residence time and provide sustained drug release locally treat recurrent lung-fungal infection. Materials & methods: VChNP has been using a simple, unique technique characterized. Pharmacokinetics, lung deposition with gamma imaging conducted optimized formulations. Results: The fluorescein isothiocyanate-labeled in was confirmed by confocal microscopy. Gamma-scintigraphic...
Abstract Betulinic acid, a plant secondary metabolite, has gained significant attention due to its antiproliferative activity over range of cancer cells. A promising betulinic acid analogue ( 2c ) with better therapeutic efficacy than parent molecule colon carcinoma cells been reported. Despite impressive biological applications, low aqueous solubility and bioavailability create difficulties for applications. To overcome these lacunae make it as drug candidate we have encapsulated the lead...
The phase diagram for a lattice system of biaxial molecules possessing $D_{2h}$ symmetry and interacting with Straley's quadrupolar pair potential in Sonnet-Virga-Durand parameterization [A. M. Sonnet, E. G. Virga, Durand, Phys. Rev. E {\bf67}, 061701 (2003)] has been determined using Monte Carlo simulation. Our results confirm that the nematogenic model yields both uniaxial nematic macroscopic phases along tricritical point transition from to nematics as predicted mean field theory. By...
Background and objective: Targeted drug delivery of nanoparticles decorated with site-specific recognition ligands is considerable interest to minimize cytotoxicity chemotherapeutics in the normal cells. The study was designed develop CD-340 antibody-conjugated polylactic-co-glycolic acid (PLGA) loaded a highly water-soluble potent anticancer drug, doxorubicin (DOX), specifically deliver entrapped DOX breast cancer Methods: showed how incorporate hydrophobic PLGA (85:15) based matrix which...
The flavone apigenin (APG), alone as well in combination with other chemotherapeutic agents, is known to exhibit potential anticancer effects various tumors and inhibit growth metastasis of melanoma. However, the nanoparticles (APG-NPs) prevent lung colonization malignant melanoma has not been investigated. APG-loaded PLGA-NPs were surface-functionalized meso-2,3-dimercaptosuccinic acid (DMSA) for treatment metastasis. DMSA-conjugated NPs (DMSA-APG-NPs) administered by an oral route...
Delivering highly water soluble drugs across blood–brain barrier (BBB) is a crucial challenge for the formulation scientists. A successful therapeutic intervention by developing suitable drug delivery system may revolutionize treatment BBB. Efforts were given here to unravel capability of newly developed fatty acid combination (stearic acid:oleic acid:palmitic = 8.08:4.13:1) (ML) as fundamental component nanocarrier deliver zidovudine (AZT) model into brain comparison was made with an...
Colistin (polymyxin E) is widely used in animal and human medicine increasingly as one of the last-resort antibiotics against Gram-negative bacilli. Due to increased use colistin treating infections caused by multidrug-resistant bacteria, resistance this antibiotic ought be monitored. The study was undertaken elucidate molecular mechanisms, genetic relationships phenotype correlations colistin-resistant isolates. Here, we report detection mcr-1 gene chicken-associated Salmonella isolates...
Technetium-99m labeled DNL-PE effectively crossed blood–brain barrier and showed a time dependant accumulation in rat brain.
Chloramphenicol-loaded (CHL) poly-d,l-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) were prepared by emulsification solvent evaporation technique either using polyvinyl alcohol (PVA) as emulsion stabilizer or polysorbate-80 (PS-80) surfactant and characterised transmission electron microscopy, zeta-potential measurements. The NPs radiolabeled with technetium-99m (99mTc) stannous reduction method. Labeling conditions optimised to achieve high-labeling efficiency, in vitro vivo (serum)...
In the present investigation folate peptide (FA-Pep) conjugated 5-fluorouracil (5-FU) loaded nanoparticles were synthesized and their tumor targeting potentiality was monitored by different in vitro vivo techniques. FA-Pep-1 FA-Pep-2 radiolabeled with 99mTc(CO)3(H2O)3. 99mTc(CO)3-FA-Pep-1 exhibited promising uptake an model (nude mice bearing HeLa cell xenograft Balb/c B16F10 melanoma tumor) as compared to 99mTc(CO)3-FA-Pep-2. then 5-FU-NPs (118 ± 4.3), confirmed XPS study. These showed...
Zoonotic and antimicrobial-resistant Escherichia coli (hereafter, E. coli) is a global public health threat which can lead to detrimental effects on human health. Here, we aim investigate the antimicrobial resistance presence of mcr-1 gene in isolated from chicken feces. Ninety-four isolates were obtained samples collected different locations Bangladesh, identified using conventional microbiological tests. Phenotypic disk diffusion tests 20 agents performed according CLSI-EUCAST guidelines,...
The aim of this study was to radiolabel ciprofloxacin (Cip) and nitrofuryl thiosemicarbazone (NFT) with the fac-[99mTc(CO)3(H2O)3]+ core evaluate ability radiopharmaceuticals as tracers in detecting sites infection. Cip NFT were radiolabeled characterized by RHPLC. stabilities preparations evaluated saline rat serum. In vitro binding studies S. aureus performed. Biodistribution conducted at different time points after injecting (i.v.) rats (intramuscularly infected aureus) well sterile...
The aim of this study was to develop 99mTc(CO)3-labeled fluoroquinolones as novel SPECT radiopharmaceuticals for imaging bacterial infection. Fluoroquinolones, e.g., ofloxacin (OFX), levofloxacin (LVX), lomefloxacin (LMX) and norfloxacin (NFX) were labeled with a fac-[99mTc(CO)3(H2O)3]+ precursor. radiochemical purity the exceeded 97% determined by thin layer chromatography HPLC. No further purification necessary before injection. Re(CO)3 complex one (levofloxacin) synthesized using...