A5101441539- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Sphingolipid Metabolism and Signaling
- Immune Cell Function and Interaction
- Immune cells in cancer
- Pharmacological Effects of Natural Compounds
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Monoclonal and Polyclonal Antibodies Research
- Protein Kinase Regulation and GTPase Signaling
- Bacteriophages and microbial interactions
- Synthesis and biological activity
- Genomics and Phylogenetic Studies
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Toxin Mechanisms and Immunotoxins
- Microbial Natural Products and Biosynthesis
- Drug Transport and Resistance Mechanisms
- Peptidase Inhibition and Analysis
- Enzyme Production and Characterization
- Lysosomal Storage Disorders Research
- Mycotoxins in Agriculture and Food
- Microbial Metabolism and Applications
- Macrophage Migration Inhibitory Factor
Bose Institute
2016-2025
Asian Development Bank Institute
2023
Indian Institute of Technology Kharagpur
2023
Institute of Livelihood Research and Training
2023
Institute for Human Development
2023
Development Bank of Japan
2023
CSIRO Land and Water
2023
Tripura University
2018
Institute of Molecular Medicine
2015
National Institute of Cholera and Enteric Diseases
2007
The platelet-derived growth factor (PDGF) receptor is a single membrane-spanning polypeptide of 180,000 daltons with ligand-stimulatable tyrosine kinase site. We have investigated changes in the structure and association state that are induced by ligand binding, but which precede autophosphorylation. Chemical cross-linking PDGF-bound 32P-labeled 125I-PDGF-labeled resulted generation radiolabeled cross-linked complex 370–390 kDa. This band, as well 180–190-kDa PDGF were recognized...
Neutrophils possess a classical Ca2+, phosphatidyl serine (PS) and diglyceride (DG)-dependent protein kinase C (beta-PKC) which was translocatable from cytosol to membrane in response elevated Ca2+ the physiologic range or pretreatment with phorbol myristate acetate (PMA). The beta-PKC purified neutrophil membranes prepared presence of eluted EGTA subjected hydroxyapatite chromatography. An 80-kDa possessing Ca/DG/PS-dependent histone phosphorylating activity recognized by monoclonal...
ABSTRACT In vitro infection of murine peritoneal macrophages with the protozoan Leishmania donovani has been found to alter signaling parameters host. The present study indicates that enhancement intracellular ceramide level in after is a major event relating macrophage dysfunction. We have previously demonstrated increased synthesis host was involved dephosphorylation extracellular signal-regulated kinase (ERK). study, we further show downregulation ERK by be associated inhibition activated...
ObjectivesThe aim of the present study was to characterize glycyrrhizic acid (GA) and assess its immunomodulatory potential in a model experimental visceral leishmaniasis.
Abstract Immune evasion within the tumor microenvironment supports malignant growth and is also a major obstacle for successful immunotherapy. Multiple cellular components soluble factors coordinate to disrupt protective immune responses. Although stromal cells are well-known their parenchymal supportive roles in cancer establishment progression, we demonstrate first time, our knowledge, that tumor-derived vascular pericytes negatively influence CD4+ T cell activation proliferation, promote...
ABSTRACT Leishmania donovani , an intracellular protozoan parasite, challenges host defense mechanisms by impairing the signal transduction of macrophages. In this study we investigated whether interleukin-10 (IL-10)-mediated alteration signaling events in a murine model visceral leishmaniasis is associated with macrophage deactivation. Primary vitro cultures macrophages infected leishmanial parasites markedly elevated endogenous release IL-10. Treatment either L. or recombinant IL-10...
Consumption of a high-fat diet (HFD) promotes reactive oxygen species (ROS) which ultimately trigger inflammation. The aim this study was to investigate the role Moringa oleifera leaf extract (MoLE) and its active component quercetin in preventing NF-κB-mediated inflammation raised by short-term HFD. Quercetin found be one major flavonoid components from HPLC MoLE. Swiss mice were fed for 15 days on HFD, both with or without MoLE/quercetin. antioxidant profile estimated liver homogenate....
The present study evaluated the hepatoprotective effect of aqueous ethanolic Moringa oleifera leaf extract (MoLE) against radiation-induced oxidative stress, which is assessed in terms inflammation and lipid peroxidation. Swiss albino mice were administered MoLE (300 mg/kg body weight) for 15 consecutive days before exposing them to a single dose 5 Gy ⁶⁰Co γ-irradiation. Mice sacrificed at 4 hours after irradiation. Liver was collected immunoblotting biochemical tests detection markers...
The visceral form of leishmaniasis is the most severe disease and particular concern due to emerging problem HIV/visceral (VL) co-infection in tropics. Till date miltefosine, amphotericin B pentavalent antimony compounds remain main treatment regimens for leishmaniasis. However, because side effects, there an urgent need alternative improved therapies combat this dreaded disease. In present study, we have used murine model evaluate potential role played by soluble leishmanial antigen (SLA)...
This study explored the role of proinflammatory chemokines macrophage inflammatory protein (MIP)-1α and chemoattractant (MCP)-1 for development antileishmanial activity. There was substantial inhibition in nitrite generation Leishmania donovani-infected macrophages. A marked elevation induction inducible nitric oxide (NO) synthase (iNOS) mRNA found chemokine-primed parasite-infected Tumor necrosis factor-α, which is priming signal NO production, also up-regulated under similar experimental...
Visceral leishmaniasis, caused by the protozoan parasite Leishmania donovani is characterized loss of ability host to generate an effective immune response. In present study, comparative potential CXC chemokines, interferon-γ–inducible protein-10 (IP-10) and interleukin-8 (IL-8) in restricting infection via release nitric oxide proinflammatory cytokines was studied vitro model. Nitric oxide, a crucial mediator for IP-10–mediated leishmanicidal activity, found be dependent on inducible...