Diabetic nephropathy (DN), an end-stage renal disorder, has posed a menace to humankind globally, because of its complex nature and poorly understandable intricate mechanism. In recent times, functional foods as potential health benefits have been gaining attention consumers researchers alike. Rich in antioxidants, the peel seed pomegranate previously demonstrated protection against oxidative-stress-related diseases, including cardiovascular disorders, diabetes, cancer.This study was...

Given that basal levels of reactive oxygen species (ROS) are higher in cancer cells, there is a growing school thought endorses pro-oxidants as potential chemotherapeutic agents. Intriguingly, cerium oxide (CeO2) nanoparticles can manifest either anti- or pro-oxidant activity function differential pH various subcellular localizations. In an acidic environment, for example, extracellular milieu CeO2 would pro-oxidant. Based on this concept, the present study designed to investigate activities...

Covalent organic frameworks (COFs) having periodicity in pores of nanoscale dimensions can be suitably designed for the building units bearing reactive functional groups at their surfaces. Thus, they are an attractive option as anticancer agent to overcome limitations chemotherapy. Herein, we first report a new porous biodegradable nitrogen containing COF material, EDTFP-1 (ethylenedianiline-triformyl phloroglucinol), synthesized using 4,4′-ethylenedianiline and 2,4,6-triformylphloroglucinol...

Three asymmetric tridentate acyl hydrazone Schiff base ligands namely L1, L2 and L3 were prepared via condensation of 4-methoxybenzohydrazide with picolinaldehyde, 1-(pyridin-2-yl)ethanone phenyl(pyridin-2-yl)methanone respectively. bio-relevant mononuclear zinc(ii) complexes [Zn(L1)Cl2]·2H2O (1), [Zn(L2)Cl2] (2) [Zn(L3)Cl2] (3) synthesized by treatment chloride the corresponding characterised usual physicochemical techniques. The solid state structures 1 3 evaluated single crystal X-ray...

Ionizing radiation is responsible for oxidative stress by generating reactive oxygen species (ROS), which alters the cellular redox potential. This change activates several sensitive enzymes are crucial in activating signaling pathways at molecular level and can lead to induced inflammation. Therefore, present study was intended assess anti-inflammatory role of ferulic acid (FA), a plant flavonoid, against radiation-induced with novel mechanistic viewpoint. FA administered (50 mg/kg body wt)...

Gold nanoparticles are predominantly used in diagnostics, therapeutics and biomedical applications. The present study has been designed to synthesize differently capped gold (AuNps) by a simple, one-step, room temperature procedure evaluate the potential of these AuNps for with glucose, 2-deoxy-D-glucose (2DG) citrate using different reducing agents. This is first report synthesis 2DG-AuNp simple method. synthesized characterized UV-Visible Spectroscopy, Fourier transform infrared...

A novel Au(III)–N-heterocyclic carbene organometallic complex supported by two N-heterocyclic (NHC) ligands was synthesized from Au(SMe2)Cl and 1-methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate via a Ag intermediate. X-ray crystallography revealed the first example of square planar geometry adopted Au(III) species stabilized NHCs chloride ligands. The aforementioned Au(I)– Au(III)–NHC complexes were found to be more potent than cisplatin against HCT 116, HepG2,...

A series of triazole-substituted quinazoline hybrid compounds were designed and synthesized for anticancer activity targeting epidermal growth factor receptor (EGFR) tyrosine kinase. Most the showed moderate to good antiproliferative against four cancer cell lines (HepG2, HCT116, MCF-7, PC-3). Compound 5b (IC50 = 20.71 μM) MCF-7 lines. Molecular docking results that compound formed hydrogen bond with Met 769 Lys 721 π-sulfur interaction 742 EGFR kinase (PDB ID: 1M17). decreases expression...

The development of drug carriers based on nanomaterials that can selectively carry chemotherapeutic agents to cancer cells has become a major focus in biomedical research. A novel pH-sensitive multifunctional envelope-type mesoporous silica nanoparticle (SBA-15) was fabricated for targeted delivery human colorectal carcinoma (HCT-116). SBA-15 functionalized with folic acid (FA), and the material loaded water-insoluble flavonoid, quercetin (QN). Additionally, acid-labile magnetite Fe3O4...

Background: NLRP3 inflammasome activation plays a critical role in mediating inflammation and NASH (non-alcoholic steatohepatitis) progression that ultimately leads to cirrhosis hepatocellular carcinoma. Melatonin (MLT) controls high-fat diet-induced the murine model by modulating mediated inflammation. P2X7R-mediated is reported several inflammatory models including NASH. Objective: The of MLT has not yet been explored. present study investigated amending nonalcoholic steatohepatitis liver....

A reaction of N1,N3-bis(3-methoxysalicylidene) diethylenetriamine (H2Vd) and Zn(NO3)2·6H2O, ZnBr2, ZnI2 Cd(NO3)2·4H2O in a methanol solution led to zinc cadmium complexes different nuclearities, [Zn2(Vd·H)2(X)2]·CH3OH (X = NO3, Br, I) [1a, 1b 1c] Cd3(Vd)2(NO3)2 (2). In 1(a-c), two H2Vd ligands bridge the metal centers whereas 2, they provide sideways support terminal Cd2+ ions, providing an all-oxygen envelope central ion. All four compounds were characterized by elemental analysis, FT-IR...

We have designed a urea functionalized novel nanoporous material, POP-PU, which showsaggregation induced white light emission in the presence of suitable polar solvents. This nanomaterial has been explored as pseudowhite emitter where polymeric luminogen moiety can interact with solvent, leading to charge transfer. Thus, solvent assisted rotational freezing nonrigid nanoparticles gives radiative and whole solution emits color temperature 8533 K. material also holds pockets...

Organic-inorganic nanohybrids are becoming popular for their potential biological applications, including diagnosis and treatment of cancerous cells. The motive this study is to synthesise a nanohybrid the therapy colorectal cancer. Here we have developed facile cost-effective synthesis folic acid (FA) templated Fe2O3 nanoparticles with excellent colloidal stability in water using hydrothermal method theranostics applications. attachment FA was confirmed various spectroscopic techniques FTIR...

A new 2D π-conjugated COF, TrzCOF has been synthesized and it showed excellent anticancer activity for the colorectal carcinoma HCT-116 cell line.

Cancer treatment using gold (I) complexes is becoming popular. In this study, a N-heterocyclic complex designated as 3 was synthesized, its cytotoxicity examined, and anti-melanoma activity evaluated in vitro vivo. Viability of cancer cells determined by MTT assay upon with various concentrations carbene (complex 3) dose time dependent manner. Mouse melanoma B16F10 were selected for further apoptotic studies, including flowcytometric analysis annexin binding, cell cycle arrest, intracellular...

Anticancer role of andrographolide is well documented. To find novel potent derivatives with improved cytotoxicity than on cancer cells, two series di-spiropyrrolidino- and di-spiropyrrolizidino oxindole prepared by cyclo-addition azomethine ylide along sarcosine or proline (viz. respectively) substitution different functional groups (-CH3, -OCH3 halogens) were examined for their cytotoxic effect a panel six human cell lines (colorectal carcinoma HCT116 pancreatic MiaPaCa-2 hepatocarcinoma...

Au(<sc>i</sc>)–NHC (<bold>3</bold>) is more potent than Au(<sc>iii</sc>)–NHC (<bold>4</bold>) and cisplatin against the four cancer cell lines.

The major drawback of anticancer therapy is the development resistance against drugs and radiation at later phase treatment which may lead to recurrences disease. Therefore, strategy was taken enhance sensitivity lung (A549) liver (HepG2) carcinoma cells by with ferulic acid (FA) prior irradiation. FA pre-treatment initially decreased reactive oxygen species (ROS) level in induced reductive stress cytostasis. To overcome this stress, cellular mechanism increased Keap1 down-regulate nuclear...

Nanoparticles (NPs) are encapsulating agents that exist in the nanometer range. They can be classified into different classes based on their properties, shapes, or sizes. Metal NPs, fullerenes, polymeric ceramic and luminescent nanoporous hybrid materials only a few examples. This study explored anticancer potential of quercetin 5-fluorouracil-encapsulated chitosan nanoparticles (CS-5-FU-QCT NPs). The were prepared by ionic gelation, efficacy mechanism action examined. CS-5-FU-QCT NPs...