A5025362065- Nanoparticle-Based Drug Delivery
- Nigella sativa pharmacological applications
- Cancer Cells and Metastasis
- Bioactive Compounds and Antitumor Agents
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Molecular Sensors and Ion Detection
- X-ray Diffraction in Crystallography
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Luminescence and Fluorescent Materials
- Genomics, phytochemicals, and oxidative stress
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Cell death mechanisms and regulation
- Cancer Mechanisms and Therapy
- Pomegranate: compositions and health benefits
- Drug Transport and Resistance Mechanisms
- Natural product bioactivities and synthesis
- Lanthanide and Transition Metal Complexes
- Immune cells in cancer
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
Jadavpur University
2022-2025
University of Calcutta
2015-2024
Salt Lake Regional Medical Center
2015-2020
Bose Institute
1974-2019
The existence of cancer stem cells (CSCs) has been associated with tumor initiation, therapy resistance, relapse, angiogenesis, and metastasis. Curcumin, a plant ployphenol, several anti-tumor effects shown to target CSCs. Here, we aimed at evaluating (i) the mechanisms underlying aggravated migration potential breast CSCs (bCSCs) (ii) curcumin in modulating same.The migratory behavior MCF-7 bCSCs was assessed by using cell adhesion, spreading, transwell migration, three-dimensional invasion...
Cationic Mesoporous silica Nanoparticle coated with hyaluronic acid conjugated polymer (HA-Dual miRNA Np) facilitated enhanced dual loading, efficient delivery and significantly inhibited tumor growth as well retarded metastasis in triple-negative breast cancer.
Lung cancer is the leading cause of cancer-related deaths worldwide. Despite decades research, treatment options for lung patients remain inadequate, either to offer a cure or even substantial survival advantage owing its intrinsic resistance chemotherapy. Our results propose effectiveness capsaicin in down-regulating VEGF expression non-small cell carcinoma (NSCLC) cells hypoxic environment. Capsaicin-treatment re-activated p53-SMAR1 positive feed-back loop these persuade p53-mediated...
Tumor‐suppressive miR‐34a, a direct target of p53, has been shown to several molecules cell survival pathways. Here, we show that capsaicin‐induced oxidative DNA damage culminates in p53 activation up‐regulate expression miR‐34a non‐small lung carcinoma (NSCLC) cells. Functional analyses further indicate restoration inhibits B lymphoma‐2 (Bcl‐2) protein withdraw the advantage these resistant NSCLC In such proapoptotic cellular milieu, where drug resistance proteins are also down‐regulated,...
The detailed molecular mechanism of transferrin-tagged thymoquinone nanoparticle mediated apoptotic induction in non-small cell lung carcinoma showing the involvement p53 dependent synergistic activation miR-34a and miR-16 pathway.
MINT‐7295816: p53 (uniprotkb:P04637) physically interacts (MI:0915) with IKK beta (uniprotkb:O14920) by anti bait coimmunoprecipitation (MI:0006)
Abstract Tumor suppressor p53 preserves the genomic integrity by restricting anomaly at gene level. The hotspots for mutation in half of all colon cancers reside p53. Hence, a p53-mutated cellular milieu targeting cancer cells may be achievable paralogue(s) Here we have shown effectiveness crocetin, dietary component, inducing apoptosis with varying status. In wild-type p53-expressing cells, one hand transactivates BAX and parallel up-regulates p53-induced death domain protein (PIDD) that...
Abstract Citrus macroptera (CM) fruit juice was used to reduce gold ions (Au 3+ ) and stabilize as‐formed nanoparticles (AuNPs). CM‐AuNPs exhibit surface Plasmon resonance (SPR) peak at 544 nm. Transmission Electron Microscope (TEM) study reveals that they are multi‐shaped, predominantly pseudo‐spherical with a diameter 20 They have charge −30 mV possess FCC lattice pattern. Particles could effectively inhibit the biofilm formation of Pseudomonas aeruginosa bacteria. Experimental shows make...
Abstract In the context of failure treatment for non alcoholic fatty liver disease (NAFLD)-mediated systemic damages, recognition novel and successful characteristic drug to combat these anomalous situations is earnestly required. The present study aimed evaluate protective value ethanol extract Coccinia grandis leaves (EECGL), naturally occurring medicinal plant, on NAFLD-mediated damage induced by high lipid diet along with monosodium glutamate (HM)-fed rats. Our uncovered that EECGL...