A5033893952- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Sensors
- X-ray Diffraction in Crystallography
- Nigella sativa pharmacological applications
- Crystallization and Solubility Studies
- Nanoparticle-Based Drug Delivery
- Electrochemical Analysis and Applications
- Bioactive Compounds and Antitumor Agents
- Estrogen and related hormone effects
- Photosynthetic Processes and Mechanisms
- Analytical chemistry methods development
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Drug Transport and Resistance Mechanisms
- Photoreceptor and optogenetics research
- Metal complexes synthesis and properties
- Crystallography and molecular interactions
- Spectroscopy and Quantum Chemical Studies
- Natural Compounds in Disease Treatment
- Lanthanide and Transition Metal Complexes
- Natural product bioactivities and synthesis
- Mass Spectrometry Techniques and Applications
- Graphene and Nanomaterials Applications
Iowa State University
2023-2025
University of Calcutta
2015-2024
University of Hyderabad
2024
Jadavpur University
2024
Janssen (United States)
2021
Cationic Mesoporous silica Nanoparticle coated with hyaluronic acid conjugated polymer (HA-Dual miRNA Np) facilitated enhanced dual loading, efficient delivery and significantly inhibited tumor growth as well retarded metastasis in triple-negative breast cancer.
The detailed molecular mechanism of transferrin-tagged thymoquinone nanoparticle mediated apoptotic induction in non-small cell lung carcinoma showing the involvement p53 dependent synergistic activation miR-34a and miR-16 pathway.
The absence of d-orbital electrons or presence full-filled in metal ions is a well-known Achilles' heel problem for the detection these by simple UV-visible study. For this reason, such as Al3+ with no Zn2+ filled challenging task. Herein, we report 2-naphthol-based fluorescent probe [1-((E)-((E)-(5-bromo-2-hydroxybenzylidene)hydrazono)methyl)naphthalen-2-ol] (H2L) that has been used to sense and discriminate via solvent regulation. exhibits excellent selectivity swift sensitivity toward...
A systematic journey from O-donor through S-donor to N-donor chelator led the development of a highly selective Au(3+) chemosensor that operates via CHEF-induced FRET mechanism. This sensing protocol avoids unwanted possible side reactions observed in alkyne-based gold sensors. DFT studies strongly support experimental facts. The probe RT-2 detects presence masking agent KI minimize Hg(2+) interference; however, RQ-2 selectively without any interference and shows reversibility...
Abstract Molecular recognition of proteins is key to their biological functions and processes such as protein–protein interactions (PPIs). The large binding interface involved an often relatively flat surface make the development selective protein-binding materials extremely challenging. A general method reported in this work construct polymeric nanoparticles from cross-linked surfactant micelles. Preparation involves first dynamic covalent chemistry that encodes signature lysines on a...
Intracellular delivery of proteins can directly impact dysregulated and dysfunctional is a key step in the fast growing field protein therapeutics. The vast majority protein-delivery systems enter cells through endocytic pathways, but endosomal escape difficult inefficient process, demanding fundamentally different methods delivery. We report ultrasmall cationic molecularly imprinted nanoparticles that bind targets with high specificity their uniquely distributed surface lysine groups....
A 4-(naphthalen-1-ylethynyl) aniline appended rhodamine based fluorescent chemosensor ‘<bold>NAP-RD</bold>’ is synthesized which undergoes through bond energy transfer in the presence of Sn<sup>2+</sup> ions mixed aqueous media.
In situ modification of glycans requires extraordinary molecular recognition highly complex and subtly different carbohydrates, followed by reactions at precise locations on the substrate. We here report synthetic catalysts that under physiological conditions cleave a predetermined oligosaccharide block such as branched trimannose or entire N-glycan glycoprotein, while nontargeted glycoproteins stay intact. The method also allows α2–6-sialylated galactosides to be removed preferentially over...
Abstract Introduction The Bruguiera cylindrica L. is a mangrove plant that typically found in coastal areas of Asia, including India. It has been known for its medicinal properties, which have utilized generations. For example, Thailand, it used to treat wounds and diarrhoea, while India, effective addressing diabetes, ulcers, other health issues. This particular study sought investigate the potential B. bark extract reducing symptoms diabetes rats. Methods In this study, we examined as an...
An amide-based smart probe (L) is explored for nanomolar detection of Mo(VI) ion in a ratiometric manner, involving hydrogen-bond-assisted chelation-enhanced fluorescence process through inhibition photoinduced electron transfer process. The recognition associated with 17-fold enhancement and confirmed by single-crystal X-ray diffraction the resulting complex (M1). Further, M1 selectively recognizes arsenite green emission their adduct (C1) an 81-fold enhancement. Interestingly, dihydrogen...
The recognition of a specific protein in blood serum amidst similar proteins is challenging and vital endeavor clinical diagnostics. Herein, we have described small-molecule probe (DFPAC-OH) that can induce self-assembly human albumin (HSA) bovine (BSA) to generate highly sustainable fluorescent organic nanoparticle (NP), useful for imaging vitro drug-delivery applications. In the midst proteins, DFPAC-OH selectively binds noncovalent manner albumin. binding tailors fluorescence properties...
Molecules offering simultaneous detection and killing of cancer cells are advantageous. Hybrid cell-selective, ROS generator betulinic acid bis-arylidene oxindole with amino propyl-linker is developed. With intrinsic fluorescence, the molecule exhibited cell-specific residence. Further, it generated ROS, triggered apoptosis, potent cytotoxicity in selectively. We demonstrate first example use isatins as conjugate for selective subsequent via apoptosis.
A single crystal X-ray structurally characterized BODIPY based probe, THBPY, derived from 4-hydroxy-5-isopropyl-2 methyl-isophthalaldehyde, detects nano-molar lysine in aqueous medium. In the presence of lysine, THBPY visibly changes its color and fluorescence profile due to formation a stable imine bond. distinctive change allows for facile discrimination over other amino acids wide range concentrations lysine. The detection limit is 0.001 μM by method 0.01 colorimetric method. probe shows...
Selective cyclooxygenase (COX)-2 inhibitors have been extensively studied for colorectal cancer (CRC) chemoprevention. Celecoxib has reported to reduce the incidence of adenomas and CRC but is also associated with an increased risk cardiovascular events. Here, we report a series gut-restricted, selective COX-2 characterized by high colonic exposure minimized systemic exposure. By establishing acute ex vivo 18F-FDG uptake attenuation as efficacy proxy, identified subset analogues that...