A5112479365- Biofuel production and bioconversion
- Enzyme Production and Characterization
- Microbial Metabolic Engineering and Bioproduction
- RNA Interference and Gene Delivery
- Enzyme Catalysis and Immobilization
- Estrogen and related hormone effects
- Enzyme-mediated dye degradation
- Tannin, Tannase and Anticancer Activities
- Nanoparticle-Based Drug Delivery
- Algal biology and biofuel production
- Protein Hydrolysis and Bioactive Peptides
- Advanced biosensing and bioanalysis techniques
- Microbial Metabolites in Food Biotechnology
- Phytase and its Applications
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Food composition and properties
- Virus-based gene therapy research
- Catalysis for Biomass Conversion
- Viral Infectious Diseases and Gene Expression in Insects
- Ubiquitin and proteasome pathways
- Biodiesel Production and Applications
- Electrochemical sensors and biosensors
- Cancer Cells and Metastasis
- Lipid Membrane Structure and Behavior
Indian Institute of Chemical Technology
2016-2025
Academy of Scientific and Innovative Research
2016-2025
Plant Lipids (India)
2025
Indian Institute of Technology Kharagpur
2015-2024
Comilla Medical College
2024
Mugda Medical College
2024
Chittaranjan National Cancer Institute
2023
Christian Medical College & Hospital
2021
University of Hyderabad
2011-2020
Indian Institute of Technology Bhubaneswar
2017
Certain human malignancies including prostate cancer overexpress sigma receptor, a membrane bound protein that binds haloperidol and various other neuroleptics with high affinity. An anisamide derivatized ligand possesses affinity for receptors we hypothesized its incorporation into the liposomes encapsulating doxorubicin (DOX) can specifically target deliver drug to cells receptors. A polyethylene glycol phospholipid was an ligand, which then incorporated DOX-loaded liposome. The resulting...
No dice: MicroRNAs (miRNAs) fine-tune gene expression, deregulation of which has been causally associated with a number debilitating conditions. Streptomycin, well-known aminoglycoside drug, binds to RNA secondary structures and is shown inhibit miR-21 function by direct binding its precursor, thus presumably interfering the processing Dicer enzyme (see scheme).
In the present article, we report in vitro and vivo delivery of doxorubicin using biosynthesized gold nanoparticles (b-Au-PP). Gold were synthesized by a simple, fast, efficient, environmentally friendly economical green chemistry approach an extract Peltophorum pterocarpum (PP) leaves. Because b-Au-PP was highly stable various physiological buffers for several weeks biocompatible both systems, designed developed nanoparticle (b-Au-PP)-based drug-delivery system (DDS) (Dox) (b-Au-PP-Dox)....
The present article emphasizes on improving the intrinsic content of resistant starch % in green banana flour through enzymatic intervention. enzyme amylopullulanase has been selected for study because its bifunctional properties that are specifically acting α 1–4 and 1–6 glycosidic linkages molecule. To evaluate effective action starch, optimization studies have performed using Response Surface Methodology (RSM), which was further compared with Artificial Neural Network (ANN) modelling....
Soaring demand for alternative fuels has been gaining wide interest due to depletion of conventional fuel, increasing petroleum prices and greenhouse gas emissions. Biodiesel, an derived from oleaginous microbes promising because short incubation time easy scale up. Oleaginous yeast Trichosporon sp. is capable utilizing glycerol agro-residues enhanced lipid synthesis. Lipid extraction biomass showed highest content with ultrasonic assisted (43 ± 0.33%, w/w) coupled process parameters than...
Breast cancer is the leading cause of malignancies among women globally. The triple negative breast (TNBC) subtype most difficult to treat and accounts for 15% all cases. Targeted therapies have been developed TNBC but come short clinical translation due acquired tumor resistance. An effective therapy against must combine properties target specificity, efficient killing, translational relevance. objective this study was formulate a nontoxic, cationic, lipid-conjugated estrogenic derivative...
Biofuels are the imperative commodities influential in future bioeconomy that can be made sustainable by utilizing hemicelluloses which primary unutilized residues obtained from a lignocellulosic ethanol refinery. The abundant fraction these include pentoses (mainly xylose). rationale behind huge loss of hemicellulosic is their heteropolymeric nature, low fermentability, lack pentose specific transporters and enzyme cascades required for fermentation natural yeast strains. These lacunae lead...
Abstract Background Asthma-COPD overlap (ACO) refers to a group of poorly studied and characterised patients reporting with disease presentations both asthma COPD, thereby making diagnosis treatment challenging for the clinicians. They exhibit higher burden in terms mortality morbidity comparison only or COPD. The pathophysiology its existence as unique entity remains unclear. present study aims determine whether ACO has distinct metabolic immunological mediator profile Methods Global...
A tannase-producing soil bacteria has been isolated and identified as Bacillus cereus. It can degrade tannic acid produce maximum tannase (0.22 U/ml) at stationary phases of growth (24 h). Maximum enzyme production occurred with initial medium pH 4.5-5.0. Partial purified showed optimum activity 4.5 40 degrees C. remains stable up to 30 C 5.0. The is salt tolerant, 2 m NaCl retains 82% original in 3 m.
Multivalent binding allows high selectivity and affinity in a ligand–protein interaction. The N-end rule pathway is ubiquitin (Ub)-dependent proteolytic system which specific E3s, called N-recognins, mediate ubiquitylation through the recognition of types 1 2, destabilizing N-terminal residues substrates. We recently identified set E3 Ub ligases (named UBR1–UBR7) containing 70-residue UBR box, we demonstrated that UBR1, UBR2, UBR4, UBR5 can bind to residues. To explore model heterovalent...