A5012899144- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Urinary Tract Infections Management
- Urological Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Dermatology and Skin Diseases
- Sexual function and dysfunction studies
- Hormonal and reproductive studies
- Neuroscience of respiration and sleep
- Ion Channels and Receptors
- Neuropeptides and Animal Physiology
- Tissue Engineering and Regenerative Medicine
- Pain Mechanisms and Treatments
- Polyomavirus and related diseases
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Diet and metabolism studies
- Botulinum Toxin and Related Neurological Disorders
- Cannabis and Cannabinoid Research
- Anesthesia and Pain Management
- Urologic and reproductive health conditions
- Kidney Stones and Urolithiasis Treatments
- Thermoregulation and physiological responses
- Stress Responses and Cortisol
University of Pittsburgh
2015-2024
UPMC Montefiore
2015-2024
Robert Bosch (Germany)
2021
Micron (United States)
2021
Micron Biomedical (United States)
2021
Harm Reduction Services
2021
University of Pittsburgh Medical Center
2015-2020
Magee-Womens Hospital
2020
Hudson Institute
2017
John Wiley & Sons (United States)
2017
Certain human malignancies including prostate cancer overexpress sigma receptor, a membrane bound protein that binds haloperidol and various other neuroleptics with high affinity. An anisamide derivatized ligand possesses affinity for receptors we hypothesized its incorporation into the liposomes encapsulating doxorubicin (DOX) can specifically target deliver drug to cells receptors. A polyethylene glycol phospholipid was an ligand, which then incorporated DOX-loaded liposome. The resulting...
Overactive bladder (OAB) is a symptom-based syndrome defined by urinary urgency, frequency, and nocturia with or without urge incontinence. The causative pathology diverse; including outlet obstruction (BOO), ischemia, aging, metabolic syndrome, psychological stress, affective disorder, microbiome, localized systemic inflammatory responses, etc. Several hypotheses have been suggested as mechanisms of OAB generation; among them, neurogenic, myogenic, urothelial are well-known hypotheses....
To measure urinary nerve growth factor (NGF) levels in patients with interstitial cystitis/bladder pain syndrome (IC/BPS), and to evaluate the role of NGF predicting response treatment, as clinical diagnosis IC/BPS is based on subjective symptoms recent investigations suggest that increased IC/BPS.Urine samples from 122 28 normal controls were measured for using an enzyme-linked immunosorbent assay. The was bladder results cystoscopic hydrodistension. Patients' perception assessed by a...
Botulinum toxin A (Allergan, Irvine, California) is a high molecular weight neurotoxin used to treat hypersensitive bladder by direct injection pass the urothelial barrier. We investigated feasibility of intravesical botulinum delivery using liposomes (Lipella Pharmaceuticals, Pittsburgh, Pennsylvania), which are phospholipid bilayered vesicles, and evaluated urodynamic immunohistochemical effect on acetic acid induced hyperactivity in rats.Liposomes (1 ml), (20 U/1 ml saline) or...
To compare urinary nerve growth factor (NGF) and prostaglandin E2 (PGE2) levels among patients with detrusor overactivity (DO), increased bladder sensation (ISB), interstitial cystitis/bladder pain syndrome(IC/BPS) controls.Urine samples were collected from 40 women IC/BPS, 54 overactive (OAB) 27 normal as controls, all a full bladder. Patients OAB further classified into subgroups of DO or IBS by urodynamic results. Urinary NGF PGE2 measured using an enzyme-linked immunosorbent assay....
No AccessJournal of UrologyInvestigative Urology1 Jun 2012Urinary Chemokines as Noninvasive Predictors Ulcerative Interstitial Cystitis Pradeep Tyagi, Kim Killinger, Vikas Jayabalan Nirmal, Michael Chancellor, and Kenneth M. Peters TyagiPradeep Tyagi , KillingerKim Killinger TyagiVikas NirmalJayabalan Nirmal ChancellorMichael Chancellor PetersKenneth View All Author Informationhttps://doi.org/10.1016/j.juro.2012.01.034AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack...
Although cannabinoid receptor expression has been demonstrated in human brain and other peripheral neuronal tissues, definitive of these receptors the bladder not reported. Consequently we investigated functional 1 2 detrusor urothelium.Human bladders were micro-dissected for (6) urothelium (8), analyzed mRNA using real-time quantitative polymerase chain reaction, protein immunohistochemistry Western blot. Functional response was tested by studying effect selective agonists on nerve evoked...
ATP is released through pannexin channels into the lumen of rat urinary bladder in response to distension or stimulation with bacterial endotoxins. Luminal plays a physiological role control micturition because intravesical perfusion apyrase ecto-ATPase inhibitor ARL67156 altered reflex activity anaesthetized rat. The release from apical and basolateral surfaces urothelium appears be mediated by separate mechanisms administration channel antagonist Brilliant Blue FCF increased capacity,...
No AccessJournal of UrologyInvestigative urology1 Oct 2006Qualitative and Quantitative Expression Profile Muscarinic Receptors in Human Urothelium Detrusoris corrected byErratais companion of99mTechnetium-Mercaptoacetyltriglycine Scintigraphy With Full Bladder Patients Severe Dysfunction Shachi Tyagi, Pradeep Suzy Van-le, Naoki Yoshimura, Michael B. Chancellor, Fernando de Miguel TyagiShachi Tyagi , TyagiPradeep Van-leSuzy Van-le YoshimuraNaoki Yoshimura ChancellorMichael Chancellor...
Purpose: We investigated the presence of functional ß1, ß2 and ß3-adrenoceptor in urothelium detrusor muscle human bladder through vitro pharmacology selective ß3 adrenoceptor agonist solabegron. Materials Methods: Expression these adrenoceptors surgically separated were using RT-PCR. The effects activating receptors studied by determining relaxation produced ß-adrenoceptors pre-contracted strips. Results: results confirmed mRNA for both detrusor. In an assay, Solabegron other agonists such...
There is clinical evidence showing that prostatic inflammation contributes to overactive bladder symptoms in male patients; however, little known about the underlying mechanisms In this study, we investigated mechanism causes detrusor overactivity by using a rat model of chemically induced inflammation. We observed significant number dorsal root ganglion neurons with dichotomized afferents innervating both prostate and bladder. also found induces urothelial NGF overexpression bladder,...