A5081129843- Research on Leishmaniasis Studies
- Porphyrin and Phthalocyanine Chemistry
- Cervical Cancer and HPV Research
- Metal-Catalyzed Oxygenation Mechanisms
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Electrochemical Analysis and Applications
- Graphene and Nanomaterials Applications
- Electrocatalysts for Energy Conversion
- Metal complexes synthesis and properties
- Carbon and Quantum Dots Applications
- Electrochemical sensors and biosensors
- Trypanosoma species research and implications
- Advanced battery technologies research
- Global Cancer Incidence and Screening
- Asymmetric Hydrogenation and Catalysis
- Metalloenzymes and iron-sulfur proteins
- Carbohydrate Chemistry and Synthesis
- Analytical Chemistry and Sensors
- Inorganic and Organometallic Chemistry
- Crystallization and Solubility Studies
- Quantum Dots Synthesis And Properties
- X-ray Diffraction in Crystallography
- Nanoplatforms for cancer theranostics
- Hemoglobin structure and function
Centre National de la Recherche Scientifique
2018-2025
King Abdullah University of Science and Technology
2020-2025
École Nationale Supérieure de Chimie de Montpellier
2023-2025
Université de Montpellier
2025
Institute for Bioengineering of Catalonia
2023-2025
University of Southampton
2025
National Institute of Technology Durgapur
2018-2024
National Institute of Technology Patna
2020-2024
Indian Association for the Cultivation of Science
2012-2023
Biological E (India)
2023
Highly fluorescent crystalline carbon nanoparticles (CNPs) have been synthesized by one step microwave irradiation of sucrose with phosphoric acid at 100 W for 3 min 40 s. This method is very simple, rapid and economical hence can be used large scale applications. The average particle sizes are to 10 nm they emit bright green fluorescence under the UV-light. Therefore, particles as a unique material bioimaging well drug delivery. To further increase property synthetic we simply...
A new and facile approach for synthesizing graphene quantum dots (GQDs) using sono-Fenton reaction in an aqueous dispersion of oxide (GO) is reported. The transmission electron microscopy (TEM) micrographs GQDs indicate its average diameter as ∼5.6 ± 1.4 nm having a lattice parameter 0.24 nm. are used to fabricate composites (PG) with water-soluble polymer, polythiophene-g-poly[(diethylene glycol methyl ether methacrylate)-co-poly(N,N-dimethylaminoethyl methacrylate)]...
Abstract Leishmania donovani-infected splenic macrophages and P388D1 (P388D1(I)) failed to activate T cells in response low dose of exogenous peptide. The membrane fluidity P388D1(I) was greater than that the normal counterpart P388D1(N), but could be reduced either by exposing cell below phase transition point or loading cholesterol into (L-P388D1(I)), this associated with enhanced Ag-presenting ability P388D1(I). Presentation endogenous leishmanial Ag, kinetoplastid protein-11, also...
Functionalized graphene-based drug delivery vehicles have conquered a significant position because functionalization improves its biocompatibility and stability in cell medium, leaving sufficient graphitic basal plane for loading through π–π stacking. In this study, poly(N-isopropylacrylamide) (PNIPAM) is covalently grafted from the surface of graphene oxide (GO) via facile, eco-friendly an easy procedure free radical polymerization (FRP) using ammonium persulfate initiator. Various...
Visual inspection after acetic acid application (VIA) and human papillomavirus (HPV) detection tests have been recommended to screen women for cervical cancer in low middle income countries. A demonstration project rural India screened 39,740 with both the compare their accuracies real population setting. The also evaluated model of screening existing primary health care facilities, evaluating positive colposcopy (and biopsy) same setup recalling diagnosed disease treatment at tertiary...
The electrochemical O2 reduction by thiolate- and imidazole-bound iron porphyrin complexes H/D isotope effects on 4e– (determined rotating disc electrochemistry) 2e– ring rates are investigated. results indicate that a thiolate axial ligand shows an effect greater than 18 47 for the reductions, respectively. Alternatively, imidazole in of 1.04 4.7 reduction, catalytic mechanism is investigated situ with resonance Raman coupled electrochemistry. data rate-determining step changes from O–O...
The emergence of antimony (Sb) resistance has jeopardized the treatment visceral leishmaniasis in various countries. Previous studies have considered part played by leishmanial parasites resistance, but involvement host factors clinical scenario remained to be investigated. Here we show that unlike infection with Sb-sensitive (Sbs) Leishmania donovani, Sb-resistant (Sb r) L. donovani induces upregulation multidrug resistance-associated protein 1 (MRP1) and permeability glycoprotein (P-gp)...
Iron porphyrin complex with a covalently attached thiolate ligand and another phenolate has been synthesized. The bound shows spectroscopic features characteristic of P450, including the hallmark absorption spectrum CO adduct. Electrocatalytic O2 reduction by this complex, which bears terminal alkyne group, is investigated both physiabsorbing on graphite surfaces (fast electron transfer rates) covalent attachment to azide terminated self-assembled monolayer (physiologically relevant using...
Here we report a surface modification approach for fluorescent silicon nanoparticle that transforms hydrophobic into water-soluble of high colloidal stability. The involves ring-opening polymerization glycidol at the hydroxyl-terminated results in hyperbranched polyglycerol grafted (Si-HPG). resultant Si-HPG has 25 nm hydrodynamic diameter, low charge, and broad emission range 450–700 with fluorescence quantum yield 6–9%. been transformed cyclic RGD peptide functionalized nanoprobe using...
The instability of [Fe-Fe]-hydrogenase and its synthetic models under aerobic conditions is an inherent challenge in their development as practical H2 producing electrodes. electrochemical oxygen reduction reaction a series model complexes the [Fe-Fe] hydrogenase investigated, dominant role bridgehead nitrogen reducing amount partially reduced species (PROS), which detrimental to stability these complexes, discovered.
A series of ‘aggregation induced emission’ active cyclometalated iridium(<sc>iii</sc>) complexes were synthesized and tested in cell imaging.
Infection with high‐risk human papillomavirus (HR‐HPV) is transient and clears on its own in majority of the women. Only a few women who have persistent infection may finally develop cervical intraepithelial neoplasia (CIN) or cancer later years. The risk progression HR‐HPV‐positive normal cervix low‐grade lesion colposcopy histopathology at baseline less studied. We performed longitudinal study 650 and/or histopathology‐proved CIN1 diagnosis to assess cumulative development high‐grade CIN....
Although calcium phosphate based nanomaterials are widely used in various biomedical application, the synthesis of high quality examples such with controlled size and shape is challenging. Here, we report a single-phase approach for length-controlled nanorods nanowires 2–5 nm diameter 10–1000 length. The synthetic method involves injection tetrabutylammonium into an oleic acid solution oleate at 200–330 °C controlling nucleation–growth kinetics by temperature, molar ratio to phosphate,...
The design and development of contrast agents (CAs) for magnetic resonance imaging (MRI) in clinical analysis is expected to improve the image spatial resolution increase detection sensitivity, especially regarding neurological disorders cancer disease. In particular, advanced CAs T1-weighted images are investigated achieve sensitive early-stage primary tumors or brain metastases. this study, we present a strategy toward diagnostic T1 MRI, based on polymer-modified MnO nanoparticles (NPs)....
Simple and straightforward thermodynamically controlled transmetalation of phosphorus‐nitrogen Zn complex to pincer cobalt nickel complexes were demonstrated. All the products well characterized by SCXRD, HRMS (positive negative mode), NMR. B‐H plots from UV‐Vis studies further justify process. Transmetalation results DFT calculations established thermodynamic stability these three in < Co Ni. The Intrinsic Bond Strength Order, Electron localization function, CHELPG‐ESP charges, Extended...
The emergence of drug-resistant superbugs poses a critical global health threat, necessitating innovative treatment strategies. Neisseria gonorrhoeae (Ng) causes sexually transmitted disease called gonorrhea, and the bacterium has shown alarming resistance to conventional antibiotics, underscoring urgent need for novel therapeutic approaches. In current study, we interfaced computational biology materials science investigate interactions between in-house synthesized metal-organic frameworks...