The redox status in pathogenesis is critically regulated by careful balance between the generation of reactive oxygen species (ROS) and their elimination. Increased ROS level above cellular tolerability threshold results apoptotic or necrotic cell death. belongs to a group highly compounds that have evolved play key roles signaling pathways. It’s widely assumed reasonable amount essential for variety biological processes. Elevated levels are known cause various pathologic conditions like...

Abstract Thrombospondins (TSPs) have been implicated as antitumor and antimetastasis factors in breast cancer. Although this effect has attributed to the antiangiogenic activity of TSPs, recent observations suggest other mechanisms may be at work. The TSP receptor CD47 (integrin-associated protein) recently reported mediate a novel form apoptosis. Here, we studied response cancer cells ligands TSP-1, agonist peptide 4N1K derived from anti-CD47 monoclonal antibody 1F7. All these killed four...

Background The present study was motivated by the need to design a safe nano-carrier for delivery of doxorubicin which could be tolerant normal cells. PCL63-b-PNVP90 loaded with (6 mg/ml), and 49.8% drug loading efficiency; it offers unique platform providing selective immune responses against lymphoma. Methods In this study, we have used micelles amphiphilic block copolymer as controlled release (DOX). DOX is physically entrapped stabilized in hydrophobic cores biological roles these were...

We have synthesized a well-defined four-arm star amphiphilic block copolymer [poly(DLLA)-b-poly(NVP)]4 [star-(PDLLA-b-PNVP)4] that consists of D,L-lactide (DLLA) and N-vinylpyrrolidone (NVP) via the combination ring-opening polymerization (ROP) xanthate-mediated reversible addition-fragmentation chain transfer (RAFT) polymerization. Synthesis polymer was verified by 1H NMR spectroscopy gel permeation chromatography (GPC). The forms spherical micelles in water as demonstrated transmission...

Abstract CD47 has been implicated in both positive and negative regulation of T cells as well cell death. To clarify the role function, we have studied mechanism death response to ligands, including mAb 1F7, thrombospondin-1, a agonist peptide derived from it. CD47−/− Jurkat (JINB8) were resistant killing by all three indicating essential CD47. Primary human also killed but only after activation with anti-CD3. CD47-mediated occurred without active caspases, DNA fragmentation, or Bcl-2...

Fas (CD95) mediates apoptosis of many cell types, but the susceptibility cells to killing by ligand and anti-Fas antibodies is highly variable. Jurkat T lacking CD47 (integrin-associated protein) are relatively resistant Fas-mediated death efficiently killed or IgM (CH11) upon expression CD47. Lack impairs events downstream activation including caspase activation, poly-(ADP-ribose) polymerase cleavage, cytochrome c release from mitochondria, loss mitochondrial membrane potential, DNA...

Recent years have witnessed an upsurge of Al3+ selective optical sensors involving simple Schiff bases to other complex organic frameworks. However, more than ∼95% such reports lack crystallographic evidence, and proposals binding sites for are based upon spectroscopic evidence only. We herein synthesized fully characterized a quinolineimine derivative (CMO) explored its potential toward efficient detection with evidence. The ongoing nonradiative photoinduced electron transfer (PET) excited...

Abstract Mammaglobin‐A is highly overexpressed in breast cancer cell lines and primary tumors. This pattern of expression restricted to mammary epithelium metastatic Thus, mammaglobin‐A‐specific T immune responses may provide an important approach for the design cancer‐specific immunotherapy. The purpose our study was define cell‐mediated response mammaglobin‐A. We determined that frequency mammaglobin‐A‐reactive CD8+ CD4+ cells patients significantly higher than observed healthy female...

Abstract CD47 is a ubiquitously expressed cell surface glycoprotein that associates with integrins and regulates chemotaxis, migration, activation of leukocytes. also ligand for signal regulatory protein α, receptor on monocytes, macrophages, granulocytes, dendritic (DC) subsets activation, adhesion, migration. Although the function in macrophages granulocytes has been studied detail, little known about role DC biology vivo. In this study we demonstrate CD47−/− mice exhibit selective...

Adenosine triphosphate (ATP) is an important transmitter that mediates various biological effects via purinergic receptors (P2 receptors) in cancer. We investigated the antitumor activity of ATP-decorated and doxorubicin (DOX)-loaded mesoporous silica with biomineralization calcium carbonate against a highly aggressive metastatic murine lymphoma called Dalton's (DL). Our results suggest this nanocomposite has unique respect to morphology properties on surface nanoparticle. DOX nanoparticles...

Complexes 1, 2 and 3 showed significant activity against K562, MCF-7, DL cancer cell lines. 1–3 higher growth inhibition than metal salts or ligands in tumour colony formation. Complex 1 exhibited anticancer cisplatin.

Dendritic cells (DC) are an important subset of antigen-presenting characterized by their potent capacity to activate immunologically naïve T cells. However, role in effector function tumor resistance is less well characterized. We report here that activated human peripheral blood DC acquire a antitumor effect against breast cancer cell lines vitro, leading growth inhibition and apoptosis the cell. The was augmented proinflammatory stimuli induced lipopolysaccharide (LPS) treatment. Tumor...

Leishmania, a protozoan parasite that causes leishmaniasis, affects 1-2 million people every year worldwide. Leishmaniasis is vector born disease and characterized by diverse group of clinical syndromes. Current treatment limited because drug resistance, high cost, poor safety, low efficacy. The urgent need for potent agents against Leishmania has led to significant advances in the development novel antileishmanial drugs. β-galactofuranose (β-Galf) an important component Leishmanial cell...

A simple coumarin–naphthalene conjugated chemosensor (<bold>R1</bold>) exhibited an excellent AIE effect in methanol/water (1 : 1).

Leishmania is an intracellular protozoan parasite which causes Leishmaniasis, a global health problem affecting millions of people throughout 89 different countries in the world. The current treatment includes use amphotericin B, antimonials, and others has major drawbacks due to toxicity, resistance, extraordinary high cost. So there urgent need development new drug targets fight against leishmaniasis. In this regard we have selected donovani Ca2+ ion channel (Ld-CC) as potential target....