A5011656287- Nigella sativa pharmacological applications
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Bioactive Compounds and Antitumor Agents
- Lanthanide and Transition Metal Complexes
- Connective tissue disorders research
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
- Natural Compounds in Disease Treatment
- Thyroid Cancer Diagnosis and Treatment
- Fungal Biology and Applications
- Autopsy Techniques and Outcomes
- Polyamine Metabolism and Applications
- Silymarin and Mushroom Poisoning
- Protein Interaction Studies and Fluorescence Analysis
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Vector-borne infectious diseases
- Phytochemistry and biological activity of medicinal plants
- Histone Deacetylase Inhibitors Research
- Cancer therapeutics and mechanisms
- Neonatal Health and Biochemistry
- Phytochemistry and Bioactivity Studies
All India Institute of Medical Sciences
1985-2024
University of Calcutta
2016-2023
Indraprastha Apollo Hospitals
2022
CARE Hospitals
2019
Cationic Mesoporous silica Nanoparticle coated with hyaluronic acid conjugated polymer (HA-Dual miRNA Np) facilitated enhanced dual loading, efficient delivery and significantly inhibited tumor growth as well retarded metastasis in triple-negative breast cancer.
The detailed molecular mechanism of transferrin-tagged thymoquinone nanoparticle mediated apoptotic induction in non-small cell lung carcinoma showing the involvement p53 dependent synergistic activation miR-34a and miR-16 pathway.
ABSTRACT Human granulocytic anaplasmosis (HGA) is an emerging, rickettsial tick-borne disease caused by Anaplasma phagocytophilum . Sero-epidemiological data demonstrate that this pathogen has a worldwide distribution. The diagnosis of HGA requires high index clinical suspicion, even in endemic areas. In recent years, increasingly been reported from Asia and described China, Japan, Korea. We serologically molecularly screened 467 patients with suspicion Anaplasmosis. present study describes...
The recognition of a specific protein in blood serum amidst similar proteins is challenging and vital endeavor clinical diagnostics. Herein, we have described small-molecule probe (DFPAC-OH) that can induce self-assembly human albumin (HSA) bovine (BSA) to generate highly sustainable fluorescent organic nanoparticle (NP), useful for imaging vitro drug-delivery applications. In the midst proteins, DFPAC-OH selectively binds noncovalent manner albumin. binding tailors fluorescence properties...
This study develops water dispersible trivalent terbium cation incorporated zinc sulfide nanoparticles for potential anti-cancer therapy and cellular imaging.
HepG2 cells (HCC), characterized by epithelial-like morphology, high proliferation rates, and nontumorigenicity, require cost-effective efficient treatment. Silymarin, a flavonoid extract of Silybum marianum, is effective in the treatment HCC. Here, we have reported comparative anticancer study well-characterized nanoformulations lactobionic acid-adorned porous PLGA-encapsulated silymarin (LA-PLGA-Sil) with only (PLGA-Sil) against cells. Treatment LA-PLGA-Sil produced significant...
Epidermal growth factor receptor (EGFR) normally over-expresses in non-small cell lung cancer (NSCLC) cells. Its mutations act as oncogenic drivers the cellular signal transduction pathway, and induce downstream activation of numerous key events involved proliferation survival. EGFR tyrosine kinase inhibitors (EGFR-TK inhibitors), such gefitinib erlotinib, have been used for a long time treatment NSCLC. However, they fail to overcome EGFR-TK mutation due acquisition drug resistance. It is...
Triple negative breast cancer (TNBC), characterized by its aggressive and highly metastatic nature, is difficult to cure the currently available therapies. In our investigation, folic-acid-adorned PEGylated graphene oxide (FA-PEG-GO) was synthesized modifying (GO) with folic acid-PEG conjugate (FA-PEG-NH2) EDC/NHS coupling reaction. FA-PEG-GO exhibited an exceptional potential attenuate cell migration of TNBC line ,MDAMB-231 as compared GO because adorned acid moiety, which rendered better...
Although comprehensive exertions have been made in late decades for treating advanced lung cancer with inclusive therapies but efficient anti-lung therapeutics are statically inadequate the clinics. Hence, compelling novel drugs considerably desired. This backdrop enticed us to unveil anticancer efficacy of astrakurkurol, derivative wild edible mushroom against cancer, whose effects not yet described. Mechanistic analysis disclosed that sensitizing effect astrakurkurol is due cell cycle...
To date, most of the accessible therapeutic options are virtually non-responsive towards triple-negative breast cancer (TNBC) due to its highly aggressive and metastatic nature. Interestingly, chemotherapy reacts soundly in many TNBC cases compared other types cancer. However, side effects chemotherapeutic agents still under cross-examination, thus prohibit their extensive uses. In this present study, we have developed a series coumarin-dihydropyrimidinone conjugates (CDHPs) subsequently...
Abstract Since the 1940s, generalized cytotoxic therapy has been a valuable tool in cancer treatment. Over years, there's significant increase developing potential drugs. However, little progress made enhancing patients' quality of life. The therapeutic index is limited due to drug's poor solubility and lack selectivity. Various carriers have explored for drug delivery enhance efficacy. Yet, gap versatile system that can adjust specific application requirements. Here, multifaceted platform...
Six preoperative and five postoperative hepatobiliary scans in children having cystic dilatation of the biliary tract were analyzed. The revealed three distinct patterns. type 1 pattern showed, early scans, good hepatic uptake radioactivity, photon deficient area(s) around porta hepatis or subhepatic region. These showed progressive accumulation radio activity delayed scans. 2 poor uptake, nonvisualization major channels, region which persisted throughout study. Preoperatively, it was...
Background: Comparison between pre-operative and post-operative effectiveness of rectal misoprostol for preventing blood loss in elective caesarean delivery.Methods: A single-blind randomized controlled study 180 full-term pregnant women were scheduled delivery. Computerized random allocation done group 1 to receive 400μg at urinary catheter insertion plus rectally after abdominal closure (preoperative i.e. 1, n=90) 2 who received 800μg (postoperative 2, n=90). Primary result was...