A5072675410- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Synthesis and Characterization of Heterocyclic Compounds
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Virus-based gene therapy research
- Gold and Silver Nanoparticles Synthesis and Applications
- Photoacoustic and Ultrasonic Imaging
- Plant biochemistry and biosynthesis
- Advanced Glycation End Products research
- Synthesis and biological activity
- Cervical Cancer and HPV Research
- ATP Synthase and ATPases Research
- Molecular Biology Techniques and Applications
- Click Chemistry and Applications
- Cancer Research and Treatments
- Protein Hydrolysis and Bioactive Peptides
- Autophagy in Disease and Therapy
- Fullerene Chemistry and Applications
- 3D Printing in Biomedical Research
Indian Institute of Chemical Technology
2014-2023
Academy of Scientific and Innovative Research
2017-2023
Council of Scientific and Industrial Research
2021
Indian Institute of Science Bangalore
2021
University of Hyderabad
2015-2017
In this report, we have designed a simple and efficient green chemistry approach for the synthesis of colloidal silver nanoparticles (b-AgNPs) that is formed by reduction nitrate (AgNO 3 ) solution using Olax scandens leaf extract.The b-AgNPs, characterized various physico-chemical techniques exhibit multifunctional biological activities (4-in-1 system).Firstly, bio-synthesized shows enhanced antibacterial activity compared to chemically synthesize (c-AgNPs).Secondly, b-AgNPs show...
Mesoporous silica material based drug delivery systems (DDSs) containing curcumin show biocompatibility in normal cells and an effective anti-cancer effect cancer cells.
In this paper, we report the synthesis of gold nanoconjugates (b-Au-LM) using aqueous leaf extract Lantana montevidensis (LM), a naturally available medicinal plant. The biosynthesized b-Au-LM was biocompatible in both vitro and vivo systems. However, LM as well exhibited significant inhibition proliferation cancer cells. Interestingly, showed enhanced anti-cancer activity compared to pristine extract. Generation reactive oxygen species (ROS) oxidative stress, which triggered upregulation...
Near infrared (NIR) fluorescence imaging is a striking modality for biomedical and clinical applications due to its deep tissue penetration low phototoxicity. The major issue with NIR dyes their non-specific distribution requirement of tagging biomolecules specific localization. Till now, there have been no agents available that can distribute into organ without the need targeted ligands, which remains as an unmet need. In present study, we demonstrate Zinnia elegans plant extract...
The development of simple, cost-effective, and advanced multifunctional technology is the need hour to combat cancer as well bacterial infections. There have been reports silver nanoparticles (AgNPs), salts, Prussian blue (PB) being used for medicinal purposes which are clinically approved. In this context, in present communication, we incorporated PB salts (silver nitrate) develop analogue (SPBANPs), a new nanomedicine formulation safer effective mode treatment strategy (2-in-1) both...
Designed recombinant proteins comprising functional domains offer selective targeting of cancer cells for the efficient delivery therapeutic agents. The efficacy these carriers can be further enhanced by conjugating engineered to nanoparticle surfaces. However, protein-loaded nanoparticle-based drug systems are not well addressed ovarian therapy. In present study, using a combinatorial approach, we designed and fabricated system combining gold nanoparticles (AuNPs) with an bi-functional...
Therapeutic agents harboring both wound healing and antibacterial activities have much demand in biomedical applications. Development of such candidates with clinically approved materials adds more advantages toward these Recently, silver metal complex nanomaterials been playing a major role medical uses especially for activity healing. In this report, we designed synthesized nitroprusside nanoparticles (abbreviated as AgNNPs) using sodium nitrate (both are FDA precursors). The (AgNNPs) were...
Targeted gene delivery of wild type tumor suppressor p53 is a promising approach to inhibit the progression ovarian cancer. Although several vehicles have been reported earlier, there paucity for targeted cancer using gold nanoparticles. As it well-known that EGFR (epidermal growth factor receptor) overexpressed in cancer, this study we hypothesized FDA approved monoclonal antibody C225 (cetuximab) targets could be used gene. With impetus, devised an wherein cationic nanoparticles (AuNPs)...
Abstract Recent research offers several approaches for the advancement of manganese‐based nanomaterials its therapeutic use. The present paper reports development smartly engineered casein manganese oxide nanobiomaterials (CMnNP) using chloride and under alkaline condition at room temperature. CMnNP are systematically characterized by various analytical techniques. biocompatibility these is observed in vitro cell viability vivo hemolysis assay. exhibit pro‐angiogenic properties, established...
Numerous prior studies on fighting cancer have been based using inhibitors of JAK-STAT pathway (signal transducer and activator transcription 3 (STAT3) inhibitor in particular), a signaling responsible for progression many types cells. However, recent shown that STAT3 activation leads to upregulation program death receptor-ligand 1 (PD-L1, an immune checkpoint protein plays major role behind evasion systems by growing tumors) expression levels tumor cells, leading enhanced suppression. This...
Molecules offering simultaneous detection and killing of cancer cells are advantageous. Hybrid cell-selective, ROS generator betulinic acid bis-arylidene oxindole with amino propyl-linker is developed. With intrinsic fluorescence, the molecule exhibited cell-specific residence. Further, it generated ROS, triggered apoptosis, potent cytotoxicity in selectively. We demonstrate first example use isatins as conjugate for selective subsequent via apoptosis.
Three-dimensional (3D) models have led to a paradigm shift in disease modeling vitro, particularly for cancer. The past decade has seen phenomenal increase the development of 3D various types cancers with focus on studying stemness, invasive behavior, angiogenesis, and chemoresistance cancer cells, as well contributions its stroma, which expanded our understanding these processes. Cancer biology is moving into exploring emerging hallmarks cancer, such inflammation, immune evasion,...