A5022330708- Planarian Biology and Electrostimulation
- Marine Ecology and Invasive Species
- RNA Interference and Gene Delivery
- Plant and Biological Electrophysiology Studies
- RNA regulation and disease
- Advanced biosensing and bioanalysis techniques
- Alzheimer's disease research and treatments
- RNA Research and Splicing
- Marine Biology and Environmental Chemistry
- Nanoparticle-Based Drug Delivery
SASTRA University
2020-2022
Institute for Stem Cell Biology and Regenerative Medicine
2019-2022
National Centre for Biological Sciences
2019
Centre for Cellular and Molecular Biology
2016-2019
Designed recombinant proteins comprising functional domains offer selective targeting of cancer cells for the efficient delivery therapeutic agents. The efficacy these carriers can be further enhanced by conjugating engineered to nanoparticle surfaces. However, protein-loaded nanoparticle-based drug systems are not well addressed ovarian therapy. In present study, using a combinatorial approach, we designed and fabricated system combining gold nanoparticles (AuNPs) with an bi-functional...
Mitochondrial state changes were shown to be critical for stem cell function. However, variation in the mitochondrial content cells and implication, if any, on differentiation is poorly understood. Here, using cellular molecular studies, we show that planarian pluripotent (PSCs) have low mass compared with their progenitors. Transplantation experiments provided functional validation neoblasts are true PSCs. Further, correlated OxPhos inhibiting transition dependent metabolism cultured...
Abstract Systemic delivery of nucleic acids to the central nervous system (CNS) is a major challenge for development RNA interference-based therapeutics due absence stability, target specificity, non-permeability blood-brain barrier (BBB), and mainly lack suitable carriers. Using designed bi-functional fusion protein TARBP-BTP, very recently we demonstrated knockdown genes in brain both AβPP-PS1 (Alzheimer’s disease, AD) wildtype C57BL/6 mice upon systemic single dose siRNA. In this report,...
Planarians are free-living flatworms that emerged as a crucial model system to understand regeneration and stem cell biology. The ability purify neoblasts, the adult population of planaria, through fluorescence-activated sorting (FACS) has tremendously increased our understanding pluripotency, specialization, heterogeneity. To date, FACS-based purification methods for neoblasts relied on nuclear dyes discriminate proliferating cells (>2N), only dividing somatic cells. However, this method...
ABSTRACT Planarians have a remarkable ability to undergo whole-body regeneration. The timely establishment of polarity at the wound site followed by specification organizing centers- anterior pole and posterior pole, are indispensable for successful In planarians, polarity, positional-information determinants predominantly expressed muscles. molecular toolkit that enables this functionality planarian muscles however remains poorly understood. Here we report SMED_DDX24, D-E-A-D Box RNA...
Summary Mitochondrial state changes were shown to be critical for stem cell function. However, variation in the mitochondrial content cells and implication, if any, on differentiation is poorly understood. Here, using cellular molecular studies, we show that planarian pluripotent (PSCs) have low mass compared its progenitors. Further, correlated with OxPhos inhibiting transition dependent metabolism cultured resulted higher PIWI-1 High neoblasts. Transplantation experiments provided...