A5039476568- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Neurotransmitter Receptor Influence on Behavior
- Histone Deacetylase Inhibitors Research
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Zebrafish Biomedical Research Applications
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Neurogenesis and neuroplasticity mechanisms
- Neurological Disease Mechanisms and Treatments
- Immune Response and Inflammation
- Graphene and Nanomaterials Applications
- X-ray Diffraction in Crystallography
- Eicosanoids and Hypertension Pharmacology
- Crystallization and Solubility Studies
- Nerve injury and regeneration
- Circadian rhythm and melatonin
- RNA Interference and Gene Delivery
- Treatment of Major Depression
- Diet, Metabolism, and Disease
- Sirtuins and Resveratrol in Medicine
- Electrolyte and hormonal disorders
Indian Institute of Chemical Technology
2016-2025
Jawaharlal Nehru Centre for Advanced Scientific Research
2025
Academy of Scientific and Innovative Research
2017-2024
Sanaria
2013-2019
University of Hyderabad
2019
Council of Scientific and Industrial Research
2013
The University of Texas Southwestern Medical Center
2001-2010
Southwestern Medical Center
2005-2009
Icahn School of Medicine at Mount Sinai
2009
National Institute of Mental Health
2000-2006
Circadian rhythms and the genes that make up molecular clock have long been implicated in bipolar disorder. Genetic evidence patients suggests central transcriptional activator of rhythms, CLOCK, may be particularly important. However, exact role this gene development disorder remains unclear. Here we show mice carrying a mutation Clock display an overall behavioral profile is strikingly similar to human mania, including hyperactivity, decreased sleep, lowered depression-like behavior, lower...
Inflammatory agonists such as lipopolysaccharide (LPS) induce robust systemic well CNS responses after peripheral administration. Responses in the innate immune system require triggering of toll-like receptor 4 (TLR4), but origin sequelas has been controversial. We demonstrate expression TLR4 transcripts mouse brain meninges, ventricular ependyma, circumventricular organs, along vasculature, and parenchymal microglia. The contribution expressed resident versus hematopoietic cells to...
Anxiety and depression are major chronic mood disorders, the etiopathology for each appears to be repeated exposure diverse unpredictable stress factors. Most of studies on anxiety related disorders performed in rodents, a good model is (CUS). In this study, we have attempted understand molecular basis neuroglial behavioral changes underlying CUS-induced simplest vertebrate model, zebrafish, Danio rerio. Zebrafish were subjected CUS paradigm which two different stressors used daily 15 days,...
The transcription factor deltaFosB (DeltaFosB), induced in nucleus accumbens (NAc) by chronic exposure to drugs of abuse, has been shown mediate sensitized responses these drugs. However, less is known about a role for DeltaFosB regulating natural rewards. Here, we demonstrate that two powerful reward behaviors, sucrose drinking and sexual behavior, increase levels the NAc. We then use viral-mediated gene transfer study how such induction influences behavioral overexpression NAc increases...
The proximal tubule contains an autonomous renin-angiotensin system that regulates transport independently of circulating angiotensin II. Androgens are known to increase expression angiotensinogen, but the effect androgens on is unknown. In this in vivo microperfusion study, we examined transport. volume reabsorptive rate Sprague-Dawley rats given dihydrotestosterone (DHT) injections was significantly higher than control vehicle (4.57 ± 0.31 vs. 3.31 0.23 nl·min −1 ·mm , P < 0.01)....
Despite significant progress in neurosurgery and radiation therapy during the past decade, overall survivability (OS) of glioblastoma patients continues to be less than 2 years. The scope systemic chemotherapy is greatly limited by poor drug transport across blood brain barrier (BBB) and, thereby, suboptimal accumulation glioma tissue. To this end, use large amino acid transporter-1 (LAT1) overexpressed both on capillary endothelial cells (BCECs) has begun. Prior reports LAT1 mediated...
The study was aimed at finding the effect of garlic and resveratrol on loss β-cells diabetic complication in streptozotocin (STZ)-induced Type-I rats.Rats were injected with single dose STZ (50 mg/kg, i.p.) for induction type 1 diabetes (Dia) compared control group.Rats from third (Dia+Gar), fourth (Dia+Resv), fifth (Dia+Met) groups fed raw homogenate (250 mg/kg/day), (25 metformin (500 mg/kg/day) orally, respectively, a period 4 weeks.Diabetic group had decreased serum insulin hydrogen...
The development of simple, cost-effective, and advanced multifunctional technology is the need hour to combat cancer as well bacterial infections. There have been reports silver nanoparticles (AgNPs), salts, Prussian blue (PB) being used for medicinal purposes which are clinically approved. In this context, in present communication, we incorporated PB salts (silver nitrate) develop analogue (SPBANPs), a new nanomedicine formulation safer effective mode treatment strategy (2-in-1) both...
Increased impulsivity caused by addictive drugs is believed to contribute the maintenance of addiction and has been linked hypofunction within orbitofrontal cortex (OFC). Recent data indicate that cocaine "self-administration" induces transcription factor DeltaFosB in OFC alters effects investigator-administered on impulsivity. Here, using viral-mediated gene transfer, overexpressing were assessed cognitive sequelae chronic self-administration as measured 5-choice serial reaction time task...
<title>Abstract</title> Cerebral ischemic preconditioning offers a promising strategy to enhance resilience severe insults. Unilateral common carotid artery occlusion (UCCAo) is valuable model simulate chronic cerebral hypoperfusion (CCH). This study explored UCCAo induced CCH as stimulus induce tolerance against transient global ischemia (tGCI) by bilateral (BCCAo) in both male and female mice. We evaluated the effects of on neuroprotection recovery through behavioral, histopathological,...