A5001597821- Neurotransmitter Receptor Influence on Behavior
- Neural and Behavioral Psychology Studies
- Gambling Behavior and Treatments
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Obsessive-Compulsive Spectrum Disorders
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Regulation of Appetite and Obesity
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Neuropharmacology Research
- Mental Health Research Topics
- Behavioral Health and Interventions
- Behavioral and Psychological Studies
- Neurological disorders and treatments
- Tryptophan and brain disorders
- Eating Disorders and Behaviors
- Decision-Making and Behavioral Economics
- Parkinson's Disease Mechanisms and Treatments
- Bipolar Disorder and Treatment
- Traumatic Brain Injury Research
- Schizophrenia research and treatment
- Nicotinic Acetylcholine Receptors Study
- Cannabis and Cannabinoid Research
- Neuroinflammation and Neurodegeneration Mechanisms
University of British Columbia
2016-2025
Uppsala University
2022
Vancouver Coastal Health
2018
Centre for Health Evaluation and Outcome Sciences
2017
University of Calgary
2017
West Virginia University
2016
University of California, San Francisco
2016
Centre for Addiction and Mental Health
2015
University of British Columbia Hospital
2011
University of California, Los Angeles
2010
The orbitofrontal cortex (OFC) and basolateral nucleus of the amygdala (BLA) share many reciprocal connections, a functional interaction between these regions is important in controlling goal-directed behavior. However, their relative roles have proved hard to dissociate. Although injury brain can cause similar effects, it has been suggested that resulting impairments arise through damage different, yet converging, cognitive processes. Patients with OFC or lesions exhibit maladaptive...
Dysregulation of the prefrontal cortex (PFC) has been implicated in impulse control disorders, including attention deficit hyperactivity disorder. A growing body evidence suggests that impulsivity is non-unitary nature, and recent data indicate ventral dorsal regions PFC are differentially involved distinct aspects impulsive behaviour, findings which may reflect differences monoaminergic regulation these regions. In current experiment, levels dopamine, serotonin their metabolites were...
Risky decision making on the Iowa Gambling Task (IGT) has been observed in several psychiatric disorders, including substance abuse, schizophrenia, and pathological gambling. Such deficits are often attributed to impaired processing within orbitofrontal cortex (OFC) because patients with damage this area or amygdala, which is strongly interconnected OFC, can likewise show enhanced choice of high-risk options. However, whether OFC amygdala impairs subjects' ability learn task, actually...
An inability to adjust choice preferences in response changes reward value may underlie key symptoms of many psychiatric disorders, including chemical and behavioral addictions. We developed the rat gambling task (rGT) investigate neurobiology underlying complex decision-making processes. As Iowa Gambling task, optimal strategy is avoid choosing larger, riskier rewards instead favor options associated with smaller but less loss and, ultimately, greater long-term gain. Given demonstrated...
Similar to other addiction disorders, the cues inherent in many gambling procedures are thought play an important role mediating their addictive nature. Animal models of gambling-related behavior, while capturing dimensions economic decision making, have yet address impact that these salient may promoting maladaptive choice. Here, we determined whether adding win-associated audiovisual a rat task (rGT) would influence making. Thirty-two male Long–Evans rats were tested on either cued or...
Current cocaine users show little evidence of cognitive impairment and may perform better when using cocaine, yet withdrawal from prolonged use unmasks dramatic deficits. It has been suggested that such impairments arise in part through drug-induced dysfunction within the orbitofrontal cortex (OFC), neurobiological mechanisms remain unknown. We observed chronic self-administration increased expression transcription factor ΔFosB both medial regions rat prefrontal cortex. However, increase OFC...
The association between impulsivity and addiction is currently a topic of intense research interest. Investigations into the neurobiological basis aspects impulse control have revealed some striking parallels brain circuitry neurochemical systems implicated in drug dependence impulsive behavior. Both processes are heavily regulated by limbic corticostriatal circuits including orbitofrontal cortex (OFC) nucleus accumbens (NAC), modulated dopamine (DA) serotonin (5-HT). Hypoactivity within OFC...