A5082549614- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Cardiovascular Function and Risk Factors
- GDF15 and Related Biomarkers
- Vitamin D Research Studies
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Nutrition and Health in Aging
- Apelin-related biomedical research
- Garlic and Onion Studies
- Effects and risks of endocrine disrupting chemicals
- Gestational Diabetes Research and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Toxic Organic Pollutants Impact
- Liver Diseases and Immunity
- Nuclear Receptors and Signaling
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Metabolomics and Mass Spectrometry Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Natural Antidiabetic Agents Studies
- Drug Transport and Resistance Mechanisms
- Cardiovascular Health and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Mitochondrial Function and Pathology
National Institute of Pharmaceutical Education and Research
2021-2024
Translational Health Science and Technology Institute
2015-2023
All India Institute of Medical Sciences
2020-2022
Indian Institute of Chemical Technology
2013-2016
We have previously reported that increased glucose levels were associated with higher serum nitric oxide (NO) in fructose-fed insulin resistant rats. However, the relationship between hyperglycemia and NO level was not clear. Therefore, present study designed to find association Type 2 diabetic (T2DM) patients T2DM cardiovascular complication.Endothelial cells (HUVEC) treated of D-glucose (10-100mM), NOS gene expression measured. Hyperglycaemia induced Sprague-Dawley rats, measured after 8...
The study was aimed at finding the effect of garlic and resveratrol on loss β-cells diabetic complication in streptozotocin (STZ)-induced Type-I rats.Rats were injected with single dose STZ (50 mg/kg, i.p.) for induction type 1 diabetes (Dia) compared control group.Rats from third (Dia+Gar), fourth (Dia+Resv), fifth (Dia+Met) groups fed raw homogenate (250 mg/kg/day), (25 metformin (500 mg/kg/day) orally, respectively, a period 4 weeks.Diabetic group had decreased serum insulin hydrogen...
Background Recently, our group identified increased platelet-mediated inflammation in type 2 diabetes (T2DM) patients, and it is a well-established risk factor for complications, particularly the development of cardiovascular diseases (CVD). Furthermore, vitamin D reported to play an important role modulation platelet hyperactivity immune function, although effect on not well studied. Hence, we aimed investigate supplementation T2DM patients. Methods After screening total 201 subjects,...
Coronary artery disease (CAD) is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). The purpose present study was to discriminate Indian CAD or without T2DM by using multiple pathophysiological biomarkers.Using sensitive multiplex protein assays, we assessed 46 markers including cytokines/chemokines, metabolic hormones, adipokines apolipoproteins for evaluating different conditions control, T2DM, (T2DM_CAD). Network analysis performed create...
The aim of this study was to investigate whether lower serum vitamin D metabolite levels were associated with altered cytokine/chemokine and metabolic hormone in three different hypertensive disorders pregnancy (HDP). Healthy (n = 30) (HDP) 30), i.e., gestational hypertension (GH), preeclampsia (PE), eclampsia (EC) subjects enrolled. Vitamin metabolites measured by UPLC/APCI/HRMS method. Circulatory 27 cytokines/chemokines 10 hormones measured. Significantly decreased 25(OH)D 1,25(OH)2D...
Abstract The purpose of the present study was to measure six vitamin D metabolites and find association between deficiency coronary artery diseases in diabetes (T2DM_CAD). Four groups [control (n = 50), type 2 (T2DM, n 71), (CAD, 28), T2DM_CAD 38)] total 187 subjects were included study. Six (D , 3 25(OH)D 1,25(OH) ), measured by UPLC/APCI/HRMS method these subjects. Although all significantly decreased as compared both control T2DM (p < 0.05), only two i.e., 0.05) with 0.05). Vitamin...
Type 2 diabetes mellitus (T2DM) is a well-established risk factor for the development of atherosclerotic coronary artery disease. Platelet hyperactivity and inflammation are associated with disease (CAD) in T2DM patients. We investigated status immune cells, platelet activation, platelet-immune cell interactions T2DM_CAD patients.The study population consisted four groups subjects, healthy control (CT, n = 20), (n 44), CAD 20) 38). immunome profiling were analysed by flow cytometry. The...
BackgroundNon-communicable diseases such as type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are causing a significant burden on the human health care system. The present study aims to implement machine learning (ML) based predictive model for T2DM, CAD their co-occurrence, followed by identifying key variables occurrence of disease.MethodsThe is data driven approach that applied various supervised ML models predict biochemical, demographic physical collected from 123...
Pregestational diabetes (PGDM) leads to developmental impairment, especially cardiac dysfunction, in their offspring. The hyperglycemic microenvironment inside the uterus alters plasticity characterized by electrical and structural remodeling of heart. altered expression several transcription factors due hyperglycemia during fetal development might be responsible for molecular defects phenotypic changes mechanism heart PGDM remains unclear. To understand 2-days old neonatal rats,...
Circulatory GDF-15, angiotensin II (Ang-II) and GDF-15 mRNA expression levels were examined in three groups, other words, control (n = 25), Type 2 diabetes (T2DM; n 25) with hypertension (T2DM_HTN; 36).T2DM T2DM_HTN subjects had significantly (p < 0.05) higher Ang-II compared subjects. Significant positive correlation was found between levels. from blood cells elevated but not T2DM Ang-II-treated (50 nM) THP-1 0.001) H9C2 altered after high glucose treatment.Collectively, our data suggest...
BackgroundCardiovascular diseases (CVD) are major health concerns and the leading cause of mortality globally. In India, tribal people limited to rural areas often associated with undiagnosed, uncontrolled disease risk factors. this study, we explore CVD factors predict ten-year in populations Assam Mizoram, Northeast India.MethodsThis community-based cross-sectional study was conducted Mizoram from 2019 2022. The details demographics, socioeconomic status, anthropometric data were...
Background Nonalcoholic fatty liver disease (NAFLD) is a complex which characterized by the deposition of fats in hepatocytes. Further, it progresses to nonalcoholic steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma. The increasing prevalence NAFLD urges find non-invasive predictive biomarkers. In this study, we sought determine increased BMP8B levels as predictors for progression NAFLD. Methods present cross-sectional circulatory were measured healthy controls (n = 56), NAFL...