A5064922328- Gut microbiota and health
- Diet and metabolism studies
- Genomics and Phylogenetic Studies
- Clostridium difficile and Clostridium perfringens research
- Nutritional Studies and Diet
- Microbial Community Ecology and Physiology
- Probiotics and Fermented Foods
- Bacteriophages and microbial interactions
- Dietary Effects on Health
- Antibiotic Resistance in Bacteria
- Helicobacter pylori-related gastroenterology studies
- Tryptophan and brain disorders
- Inflammatory Bowel Disease
- Food Security and Health in Diverse Populations
- Metabolomics and Mass Spectrometry Studies
- Microscopic Colitis
- RNA and protein synthesis mechanisms
- Mycobacterium research and diagnosis
- Machine Learning in Bioinformatics
- COVID-19 Clinical Research Studies
- Colorectal Cancer Screening and Detection
- Gastrointestinal motility and disorders
- Child Nutrition and Water Access
- Glycosylation and Glycoproteins Research
- Gene expression and cancer classification
Indraprastha Institute of Information Technology Delhi
2022-2025
Indian Institute of Technology Delhi
2022-2025
APC Microbiome Institute
2019-2024
University College Cork
2019-2024
National University of Ireland
2020-2023
Translational Health Science and Technology Institute
2017-2021
Genome Institute of Singapore
2016-2020
Tata Consultancy Services (India)
2009-2017
University of Science and Technology Chittagong
2012
Indian Institute of Technology Kanpur
2009
Objective Ageing is accompanied by deterioration of multiple bodily functions and inflammation, which collectively contribute to frailty. We others have shown that frailty co-varies with alterations in the gut microbiota a manner accelerated consumption restricted diversity diet. The Mediterranean diet (MedDiet) associated health. In NU-AGE project, we investigated if 1-year MedDiet intervention could alter reduce Design profiled 612 non-frail or pre-frail subjects across five European...
Interaction between disease-microbiome associations and ageing has not been explored in detail. Here, using age/region-matched sub-sets, we analysed the gut microbiome differences across five major diseases a multi-cohort dataset constituting more than 2500 individuals from 20 to 89 years old. We show that display specific age-centric trends. Ageing-associated alterations towards disease-like configuration occur colorectal cancer patients, thereby masking disease signatures. identified...
The gut microbiome is a modifier of disease risk because it interacts with nutrition, metabolism, immunity and infection. Aging-related health loss has been correlated transition to different states. Microbiome summary indices including alpha diversity are apparently useful describe these states but belie taxonomic differences that determine biological importance. We analyzed 21,000 fecal microbiomes from seven data repositories, across five continents spanning participant ages 18-107 years,...
Malnutrition is a global health problem affecting more than 300 million pre-school children worldwide. It one of the major concerns in India since around 50% below age two suffer from various forms malnutrition. The gut microbiome plays an important role nutrient pre-processing, assimilation and energy harvest food. Consequently, dysbiosis microbiota has been implicated malnutrition.Metagenomics approach was adopted to investigate sampled 20 rural Indian with varying nutritional status....
Abstract Motivation:One of the first steps in metagenomic analysis is assignment reads/contigs obtained from various sequencing technologies to their correct taxonomic bins. Similarity-based binning methods assign a read taxon/clade, based on pattern significant BLAST hits generated against sequence databases. Existing methods, which use bit-score as sole parameter ascertain significance hits, have limited specificity and accuracy binning. A new algorithm, called SOrt-ITEMS introduced,...
The diversity and basic functional attributes of the gut microbiome healthy Indians is not well understood. This study investigated three Indian communities: individuals residing in rural urban (n = 49) sea level Ballabhgarh areas high altitude Leh, Ladakh North India 35). Our revealed that communities dominated by Firmicutes followed Bacteroidetes, Actinobateria Proteobacteria. Although, 54 core bacterial genera were detected across distinct communities, composition displayed specific...
Abstract Background Malnutrition, a major health problem, affects significant proportion of preschool children in developing countries. The devastating consequences malnutrition include diarrhoea, malabsorption, increased intestinal permeability, suboptimal immune response, etc. Nutritional interventions and dietary solutions have not been effective for treatment till date. Metagenomic procedures allow one to access the complex cross-talk between gut its microbial flora understand how...
The Bay of Bengal is known as the epicenter for seeding several devastating cholera outbreaks across globe. Vibrio cholerae , etiological agent cholera, has extraordinary competency to acquire exogenous DNA by horizontal gene transfer (HGT) and adapt them into its genome structuring metabolic processes, developing drug resistance, colonizing human intestine. Antimicrobial resistance (AMR) in V. become a global concern. However, little about identity traits, source AMR genes, acquisition...
Motivation Carbohydrate Active enzyme (CAZyme) families, encoded by human gut microflora, play a crucial role in breakdown of complex dietary carbohydrates into components that can be absorbed our intestinal epithelium. Since nutritional wellbeing an individual is dependent on the nutrient harvesting capability microbiome, it important to understand how CAZyme repertoire influenced factors like age, geography and food habits. Results This study reports comprehensive in-silico analysis...
Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and associated clinical sequelae requires well-coordinated metabolic immune responses that limit viral spread promote recovery of damaged systems. However, the role gut microbiota in regulating these has not been thoroughly investigated. In order to identify mechanisms underpinning interactions with host systems influence disease 2019 (COVID-19) outcomes, we performed a multi-omics analysis on...
The spread of antibiotic resistance, originating from the rampant and unrestrictive use antibiotics in humans livestock over past few decades has emerged as a global health problem. This problem been further compounded by recent reports implicating gut microbial communities to act reservoirs resistance. We have profiled presence probable resistance genes flora 275 individuals eight different nationalities. For this purpose, available metagenomic data sets corresponding microbiomes were...
This study describes microbial diversity in four tropical hot springs representing moderately thermophilic environments (temperature range: 40-58°C; pH: 7.2-7.4) with discrete geochemistry. Metagenome sequence data showed a dominance of Bacteria over Archaea; the most abundant phyla were Chloroflexi and Proteobacteria, although other also present, such as Acetothermia, Nitrospirae, Acidobacteria, Firmicutes, Deinococcus-Thermus, Bacteroidetes, Thermotogae, Euryarchaeota, Verrucomicrobia,...
Humans are exposed to numerous xenobiotics, a majority of which in the form pharmaceuticals. Apart from human enzymes, recent studies have indicated role gut bacterial community (microbiome) metabolizing xenobiotics. However, little is known about contribution plethora microbiome xenobiotic metabolism. The present study reports results analyses on enzymes various microbiomes. A total 397 available metagenomes individuals varying age groups 8 nationalities were analyzed. Based diversities and...
Abstract Motivation: Compared with composition-based binning algorithms, the accuracy and specificity of alignment-based algorithms is significantly higher. However, being alignment-based, latter class require enormous amount time computing resources for huge metagenomic datasets. The motivation was to develop a approach that can analyze datasets as rapidly approaches, but nevertheless has algorithms. This article describes hybrid (SPHINX) achieves high efficiency by utilizing principles...
The gastric microbiome is suspected to have a role in the causation of diseases by Helicobacter pylori. Reports on their relative abundance vis-à-vis H. pylori are available from various ethnic and geographic groups, but little known about interaction patterns. Endoscopic mucosal biopsy samples antrum corpus 39 patients with infection were collected microbiomes analyzed 16S rDNA profiling. Four groups identified, which harbored as well diverse group bacteria including Lactobacillus,...