A5072173915- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition, Genetics, and Disease
- Obesity, Physical Activity, Diet
- Obesity and Health Practices
- Gestational Diabetes Research and Management
- Nutritional Studies and Diet
- Birth, Development, and Health
- Metabolism, Diabetes, and Cancer
- Pharmacology and Obesity Treatment
- Health and Medical Studies
- Diabetes Treatment and Management
- Regulation of Appetite and Obesity
- Cardiovascular Disease and Adiposity
- Bariatric Surgery and Outcomes
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet, Metabolism, and Disease
- Nutrition and Health in Aging
- Chronic Disease Management Strategies
- Eating Disorders and Behaviors
- Diabetes and associated disorders
- Metabolomics and Mass Spectrometry Studies
- Fatty Acid Research and Health
Technical University of Munich
2016-2025
Klinikum rechts der Isar
2015-2024
Fresenius (Germany)
2015-2024
Deutsches Diabetes-Zentrum e.V.
2004-2024
Leibniz-Institute for Food Systems Biology at the Technical University of Munich
2014-2024
Heinrich Heine University Düsseldorf
2004-2024
Else Kröner-Fresenius-Stiftung
2012-2024
München Klinik
2005-2024
German Center for Diabetes Research
2014-2024
Fulda University of Applied Sciences
2015-2024
Obesity is recognised as a global epidemic and the most prevalent metabolic disease world-wide. Specialised obesity services, however, are not widely available in Europe, care can vary enormously across European regions. The Association for Study of (EASO, www.easo.org) has developed these criteria to form pan-European network accredited EASO-Collaborating Centres Management (EASO-COMs) accordance with accepted academic guidelines. This will include university, public private clinics ensure...
Adipocytes are known to release a variety of factors that may contribute the proinflammatory state characteristic for obesity. This secretory function is considered provide basis obesity-related complications such as type 2 diabetes and atherosclerosis.To get better insight into possible underlying mechanisms, we investigated effect adipocyte size on adipokine production secretion.Protein secretion mRNA expression in cultured adipocytes separated according cell from 30 individuals undergoing...
Genomewide association studies can be used to identify disease-relevant genomic regions, but interpretation of the data is challenging. The FTO region harbors strongest genetic with obesity, yet mechanistic basis this remains elusive.
Adipose tissue inflammation may play a critical role in the pathogenesis of insulin resistance (IR). The present study examined lymphocytes adipose and IR.In mouse model obesity-mediated IR, high-fat diet (HFD) induced IR already after 5 weeks, which was associated with marked T-lymphocyte infiltration visceral tissue. In contrast, recruitment macrophages delayed an increase MAC3-positive staining F4/80 mRNA expression 10 weeks HFD, suggesting dissociation macrophage invasion into...
Stromal-vascular cells obtained from adult human subcutaneous adipose tissue were cultured in a chemically defined serum-free medium. In the presence of 0.2 nM triiodothyronine and 0.5 microM insulin, up to 25% able undergo terminal differentiation within 18 d, as assessed by lipid accumulation expression lipoprotein lipase (LPL) glycerol-3-phosphate dehydrogenase (GPDH) activities. Addition cortisol resulted potent dose-dependent stimulation process. Cortisol could be replaced dexamethasone...
The aim of this study was to investigate the regulation leptin expression and production in cultured human adipocytes using model vitro differentiated adipocytes. Freshly isolated preadipocytes did not exhibit significant mRNA protein levels as assessed by reverse transcriptase (RT)-polymerase chain reaction (PCR) radioimmunoassay (RIA). However, during differentiation induced a defined adipogenic serum-free medium, cellular released into medium increased considerably accordance with lipid...
The prevalence and socioeconomic burden of type 2 diabetes (T2DM) associated co-morbidities are rising worldwide.This guideline provides evidence-based recommendations for preventing T2DM.A European multidisciplinary consortium systematically reviewed the evidence on effectiveness screening interventions T2DM prevention using SIGN criteria.Obesity sedentary lifestyle main modifiable risk factors. Age ethnicity non-modifiable Case-finding should follow a step-wise procedure questionnaires...
Abstract Objective To compare the chondrogenic potential of human bone marrow–derived mesenchymal stem cells (BMSC) and adipose tissue–derived stromal (ATSC), because availability an unlimited cell source replacing chondrocytes could be strongly beneficial for therapy, tissue engineering, in vitro drug screening, development new therapeutic options to enhance regenerative capacity cartilage. Methods Quantitative gene expression common cartilage interaction molecules was analyzed using...
Obesity has become an epidemic problem in western societies, contributing to metabolic diseases, hypertension, and cardiovascular disease. Overweight obesity are frequently associated with increased plasma levels of aldosterone. Recent evidence suggests that human fat is a highly active endocrine tissue. Therefore, we tested the hypothesis adipocyte secretory products directly stimulate adrenocortical aldosterone secretion. Secretory from isolated adipocytes strongly stimulated...
Metabolic challenge protocols, such as the oral glucose tolerance test, can uncover early alterations in metabolism preceding chronic diseases. Nevertheless, most metabolomics data accessible today reflect fasting state. To analyze dynamics of human metabolome response to environmental stimuli, we submitted 15 young healthy male volunteers a highly controlled 4 d protocol, including 36 h fasting, and lipid tests, liquid test meals, physical exercise, cold stress. Blood, urine, exhaled air,...
Adipocyte-derived extracellular vesicles (AdEVs) are membranous nanoparticles that convey communication from adipose tissue to other organs. Here, delineate their role as messengers with glucoregulatory nature, we paired fluorescence AdEV-tracing and SILAC-labeling (phospho)proteomics, revealed AdEVs transfer functional insulinotropic protein cargo into pancreatic β-cells. Upon transfer, AdEV proteins were subjects for phosphorylation, augmented GPCR/cAMP/PKA signaling by increasing total...
Abstract Beneficial gut bacteria are indispensable for developing colonic mucus and fully establishing its protective function against intestinal microorganisms. Low-fiber diet consumption alters the bacterial configuration disturbs this microbe-mucus interaction, but specific microbial metabolites responsible maintaining remain poorly understood. By using human-to-mouse microbiota transplantation ex vivo analysis of function, we here show as a proof-of-concept that individuals who increase...
Recent studies demonstrated significantly higher serum leptin concentrations in females as compared with males, even after correction for differences body fat mass. The aim of our study was to measure a large group obese children and adolescents determine the possible role sex steroid hormones on both production human adipocytes. Obese girls were found have than boys at same degree adiposity (25.2+/-14.1 vs. 17.2+/-12.6 ng/ml, P < 0.001). In multiple regression analysis age mass index...
To study the in vitro differentiation of human adipocyte precursor cells and its regulation by hormones, primary cultures stromal vascular adipose tissue were established. A 30- to 70-fold increase number developing fat was achieved addition cortisol or related corticosteroids presence insulin. Either two hormones alone ineffective. The stimulatory action dose dependent occurred at physiological concentrations. results suggest that glucocorticoids may play a role development hyperplastic...