A5102914257- Medical Imaging and Pathology Studies
- Soft tissue tumor case studies
- Sarcoma Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Bone Tumor Diagnosis and Treatments
- Hematological disorders and diagnostics
- Neuroendocrine Tumor Research Advances
- Tuberculosis Research and Epidemiology
- Oral and Maxillofacial Pathology
- Vascular Tumors and Angiosarcomas
- IgG4-Related and Inflammatory Diseases
- Radiomics and Machine Learning in Medical Imaging
- Sarcoidosis and Beryllium Toxicity Research
- Prostate Cancer Treatment and Research
- Medical Imaging Techniques and Applications
- Infectious Diseases and Tuberculosis
- Tumors and Oncological Cases
- Gastrointestinal disorders and treatments
- Actinomycetales infections and treatment
- Skin Diseases and Diabetes
- Cutaneous lymphoproliferative disorders research
- COVID-19 and Mental Health
- Inflammatory Myopathies and Dermatomyositis
- Peptidase Inhibition and Analysis
Sri Ramachandra Institute of Higher Education and Research
2025
All India Institute of Medical Sciences
2019-2023
German Center for Diabetes Research
2022-2023
Heinrich Heine University Düsseldorf
2022-2023
Deutsches Diabetes-Zentrum e.V.
2022-2023
Creative Commons
2020-2023
Cancer Institute (WIA)
2023
University of Calicut
2023
All India Institute of Medical Sciences Bhopal
2021
All India Institute of Medical Sciences Raipur
2021
Adipocyte-derived extracellular vesicles (AdEVs) are membranous nanoparticles that convey communication from adipose tissue to other organs. Here, delineate their role as messengers with glucoregulatory nature, we paired fluorescence AdEV-tracing and SILAC-labeling (phospho)proteomics, revealed AdEVs transfer functional insulinotropic protein cargo into pancreatic β-cells. Upon transfer, AdEV proteins were subjects for phosphorylation, augmented GPCR/cAMP/PKA signaling by increasing total...
Abstract The development of single-molecule co-agonists for the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIP) (GIPR) is considered a breakthrough in treatment obesity type 2 diabetes. But although GIPR–GLP-1R co-agonism decreases body weight with superior efficacy relative to GLP-1R agonism alone preclinical 1–3 clinical studies 4,5 , role GIP regulating energy metabolism remains enigmatic. Increasing evidence suggests that...
Dual agonists activating the peroxisome proliferator-activated receptors alpha and gamma (PPARɑ/ɣ) have beneficial effects on glucose lipid metabolism in patients with type 2 diabetes, but their development was discontinued due to potential adverse effects. Here we report design preclinical evaluation of a molecule that covalently links PPARɑ/ɣ dual-agonist tesaglitazar GLP-1 receptor agonist (GLP-1RA) allow for GLP-1R-dependent cellular delivery tesaglitazar. GLP-1RA/tesaglitazar does not...
Immune checkpoint inhibitors (ICIs) are associated with specific immune-related adverse events (irAEs) which unique compared to cytotoxic chemotherapy.For life-threatening including grade 3 or more, permanent discontinuation of the ICIs is recommended, albeit without much robust evidence.Safe re-challenge concurrent immunosuppression has been reported irAEs like gastrointestinal toxicity and arthritis.Here we present a case lady undifferentiated pleomorphic sarcoma programmed death ligand1...
<sup>68</sup>Ga-NOTA Glu-Urea-Lys (NGUL) is a novel prostate-specific membrane antigen (PSMA)–targeting tracer used for PET/CT imaging. This study aimed to compare performance in the detection of primary and metastatic lesions biodistribution between <sup>68</sup>Ga-NGUL <sup>68</sup>Ga-PSMA-11 same patients with prostate cancer. <b>Methods:</b> Eleven cancer were prospectively recruited. The quantitative uptake was determined normal organs lesions. <b>Results:</b><sup>68</sup>Ga-NGUL showed...
Langerhans cell histiocytosis is a disorder of the mononuclear phagocytic system. Virtually any organ can be involved, bone, skin, lungs, and pituitary gland being most common. We describe case 30-year-old man who presented with painless neck swelling. 18 F-FDG PET/CT showed bilateral bulky parotid submandibular glands increased metabolic activity. Histopathology confirmed diagnosis histiocytosis. To our knowledge, there has been no description findings in salivary literature. aim to aid...
Lincoln sign or black beard is one of the signs that have been classically described on bone scintigraphy in monostotic Paget disease, when mandible involved. Extensive involvement causes increased radiotracer uptake from mandibular condyle to other, resembling a beard. We present case 14-year-old girl with primary hyperparathyroidism who underwent an 18 F-fluorocholine PE/CT locate parathyroid adenoma. MIP image PET/CT incidentally showed due mandible.
Abstract Isolated pancreatic metastasis from choroidal melanoma is a rare phenomenon. We describe case of 38-year-old woman who underwent enucleation surgery for right and subsequently developed lesions in the pancreas 10 years after enucleation, which were depicted on 68 Ga-DOTANOC PET/CT confirmed to be surgical histopathology.
We present the case of a 60-year-old man who was being evaluated for 2 intra-abdominal masses. The masses were tracer avid on 68 Ga-DOTANOC PET/CT and suggestive neuroendocrine tumor. Histopathology, however, confirmed to be hemangiopericytoma. Hemangiopericytoma comes under umbrella solitary fibrous tumors, rare tumor group arising from mesenchymal cells. Solitary tumors commonly arise pleura but can occur anywhere in body. Intra-abdominal hemangiopericytoma are extremely should kept mind...
Abstract Amyloidosis is a disorder resulting from the deposition of fibrillary protein in extracellular tissue and can be classified into primary, secondary, familial, senile types. Isolated lymph node amyloidosis without any other organ involvement very rarely seen clinical parlance, diagnosis remains challenging owing to nonspecific imaging findings. We present case 50-year-old man with lymphadenopathy, which was later confirmed on biopsy serum-free light chain assay efficacious use 18...
Wermer/MEN1 syndrome is composed of the triad pancreatic, pituitary, and parathyroid (3P's) tumors. We describe Ga-DOTANOC PET/CT findings a 43-year-old man, which revealed classic 3P's MEN1 with somatostatin receptor expression. The patient further underwent surgery for lesions, were suggestive adenomas.
Inflammatory myofibroblastic tumor (IMT) or inflammatory pseudotumors are a rare group of tumors usually affecting children and young adults. They occur in various anatomic locations, with most common being the lung accounting for almost 95% cases. We present case 4-year-old girl who presented fever dull abdominal pain 6 months clinically palpable left hypochondrium mass. On suspicion mesenteric/gastric neuroendocrine tumor, 68Ga-DOTA-NOC positron-emission tomography-computed tomography was...
Metastasis to the scrotal sac is a very rare phenomenon. We present case of 45-year-old man diagnosed with locally advanced acinar adenocarcinoma prostate, post bilateral orchidectomy and radiotherapy treatment, who showed rising trend serum PSA levels discovery metastasis on serial Ga-prostate-specific membrane antigen PET/CT scans.
Perivascular epithelioid cell tumors (PEComas) are a rare variety of mesenchymal composed distinctive cells that show focal association with blood vessel walls and usually express melanocytic smooth muscle markers. We present case 38-year-old male, diagnosed PEComa the pelvic cavity who underwent serial 18F-fluorodeoxyglucose positron emission tomography-computed tomography scans for assessment response to chemotherapeutic combination irinotecan temozolomide.
Extragastrointestinal stromal tumors (EGISTs) are rare mesenchymal occurring outside the gastrointestinal tracts that have similar histological and immunohistochemical characteristics to those of tumors. EGISTs involving urinary bladder extremely with very few reports mentioned in literature. We present a case 48-year-old man, known biopsy-proven EGIST presented recurrence after partial cystectomy 18F-fluorodeoxyglucose positron emission tomography–computed tomography scans documenting...
We describe the case of a 54-year-old woman with triple-negative breast cancer whose baseline F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) showed hypermetabolic left primary, ipsilateral axillary lymphadenopathy, lung nodules, and mediastinal lymph nodes. Histopathological examination tissue from nodes confirmed diagnosis sarcoid-like reaction. Chemotherapy may induce or cause flare-up malignancy-associated However, in our patient's post-chemotherapy...
A 48-year-old male with known tubercular osteomyelitis of the left elbow and chronic renal failure presented PTH independent hypercalcemia underwent F-18 fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) to look for any underlying malignancy that might be causing his hypercalcemia. The PET/CT did not reveal malignancy, but extensive metastatic calcification small- medium-sized arteries was noted throughout body relative sparing large vessels. Alkaline tissue such...
Askin tumors are rare malignant neoplasms located in the thoracopulmonary region and mainly occur children adolescents. In this report, we describe a case of histologically proven Askin's tumor 24-year-old male. The patient was admitted with history 3-month lower back pain presentation paraparesis.
Askin’s tumors are rare malignant neoplasms located in the thoracopulmonary region and mainly occur children adolescents. In this report, we describe a case of histologically proven tumor 24-year-old male. The patient was admitted with history 3-month lower back pain presentation paraparesis.
Background: Lack of awareness among healthcare professionals is cited as one the main reasons along with under reporting adverse drug reactions. Knowledge, attitude, and practice (KAP) studies can help to understand various issues improve pharmacovigilance system.
 Objectives: The present study was undertaken assess knowledge, practices regarding ADR at departments hospitals in Northern Kerala get an insight into causes under-reporting ADRs.
 Materials Methods: data collected using...