A5006979994- Pancreatic function and diabetes
- Erythrocyte Function and Pathophysiology
- Receptor Mechanisms and Signaling
- Regulation of Appetite and Obesity
- Neuropeptides and Animal Physiology
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Ubiquitin and proteasome pathways
- Lower Extremity Biomechanics and Pathologies
- Knee injuries and reconstruction techniques
- Diabetes and associated disorders
- Total Knee Arthroplasty Outcomes
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Diabetes Treatment and Management
- Urinary and Genital Oncology Studies
- Diabetes Management and Research
- Single-cell and spatial transcriptomics
- Chronic Lymphocytic Leukemia Research
- Phagocytosis and Immune Regulation
- Autophagy in Disease and Therapy
Helmholtz Zentrum München
2022-2024
German Center for Diabetes Research
2022-2024
Heinrich Heine University Düsseldorf
2022-2024
Deutsches Diabetes-Zentrum e.V.
2022-2024
Oxford University Hospitals NHS Trust
2023
Technical University of Munich
2023
Max Planck Institute of Biochemistry
2022
University College London
2017
Abstract The development of single-molecule co-agonists for the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIP) (GIPR) is considered a breakthrough in treatment obesity type 2 diabetes. But although GIPR–GLP-1R co-agonism decreases body weight with superior efficacy relative to GLP-1R agonism alone preclinical 1–3 clinical studies 4,5 , role GIP regulating energy metabolism remains enigmatic. Increasing evidence suggests that...
The glucose-dependent insulinotropic polypeptide (GIP) decreases body weight via central GIP receptor (GIPR) signaling, but the underlying mechanisms remain largely unknown. Here, we assessed whether regulates and glucose control GIPR signaling in cells that express leptin (Lepr).
The development of haematopoietic stem cells into mature erythrocytes - erythropoiesis is a controlled process characterized by cellular reorganization and drastic reshaping the proteome landscape. Failure ordered associated with anaemias haematological malignancies. Although ubiquitin system known crucial post-translational regulator in erythropoiesis, how erythrocyte reshaped poorly understood. By measuring proteomic landscape vitro human models, we found dynamic differential expression...
During pancreas development endocrine cells leave the ductal epithelium to form islets of Langerhans, but morphogenetic mechanisms are incompletely understood. Here, we identify Ca
The consequences of mutations in genes associated with monogenic forms diabetes on human pancreas development cannot be studied a time-resolved fashion vivo. More specifically, if recessive the insulin gene influence pancreatic endocrine lineage formation is still an unresolved question. To model extremely reduced levels patients mutations, we generated novel knock-in H2B-Cherry reporter induced pluripotent stem cell (iPSC) line expressing no upon differentiation to cell-derived (SC-) β...
A 47-year-old man attended the emergency department following trauma during sexual intercourse after which he developed penile swelling and haematuria several hours later. fracture was suspected but given slightly atypical history, ultrasound performed to look for a fracture. Given history of haematuria, both standard Doppler microbubble-enhanced retrograde urethrogram were performed. The confirmed diagnosis fracture, microbubble demonstrated urethral injury. This facilitated prompt surgical...