A5075437310- Cancer-related Molecular Pathways
- Protein Kinase Regulation and GTPase Signaling
- Wnt/β-catenin signaling in development and cancer
- Pancreatic and Hepatic Oncology Research
- Microtubule and mitosis dynamics
- Adipokines, Inflammation, and Metabolic Diseases
- Crystallization and Solubility Studies
- Cancer Genomics and Diagnostics
- X-ray Diffraction in Crystallography
- Cancer Research and Treatments
- Gastrointestinal Tumor Research and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Cell death mechanisms and regulation
- Gastric Cancer Management and Outcomes
- Alzheimer's disease research and treatments
- Liver Disease Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Adipose Tissue and Metabolism
- Melanoma and MAPK Pathways
- Cellular Mechanics and Interactions
- Cancer-related gene regulation
- Advanced biosensing and bioanalysis techniques
- Cancer, Lipids, and Metabolism
Universität Ulm
2016-2025
University Hospital Ulm
2015-2024
Kiel University
2019
Otto-von-Guericke University Magdeburg
2016
University Hospital in Halle
2016
University of Zurich
2016
Leibniz Institute of Virology (LIV)
1991-2012
Ruijin Hospital
2012
Shanghai University
2012
Hammersmith Hospital
2009
Adipose tissue inflammation may play a critical role in the pathogenesis of insulin resistance (IR). The present study examined lymphocytes adipose and IR.In mouse model obesity-mediated IR, high-fat diet (HFD) induced IR already after 5 weeks, which was associated with marked T-lymphocyte infiltration visceral tissue. In contrast, recruitment macrophages delayed an increase MAC3-positive staining F4/80 mRNA expression 10 weeks HFD, suggesting dissociation macrophage invasion into...
Abstract Dietary polyunsaturated fatty acids (PUFA) are increasingly recognized for their health benefits, whereas a high production of endogenous – process called de novo lipogenesis (DNL) - is closely linked to metabolic diseases. Determinants PUFA incorporation into complex lipids insufficiently understood and may influence the onset progression Here we show that acid synthase (FASN), key enzyme DNL, critically determines use dietary in mice humans. Moreover, combination FASN inhibition...
Abstract Background C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune cell activation via unknown molecular mechanisms. Results In multi-translational study systemic inflammation, we found time- and inflammation-dependent pCRP dissociation mCRP. We were able confirm that mCRP co-localizes with leukocytes...
Piwi proteins and their interaction with piRNAs have rapidly emerged as important contributors to gene regulation, indicating crucial function in germline stem cell development. However, data on the Hiwi 1 (Hiwi) gene, one of four human homologues, are still scarce. Therefore, we investigated mRNA expression microdissected PDAC tissues from patients ductal adenocarcinoma pancreas (PDAC) by quantitative real-time PCR protein immunohistochemistry. Elevated levels transcripts were measured 40...
Hyperglycemia and insulin resistance frequently occur in critically ill morbidly obese (MO) patients. Both conditions are associated with altered serum levels of cytokines adipokines. In addition, obesity related alterations adipokine expression contribute to metabolic syndrome. this study we examined the adipocytokine profile patients, MO healthy blood donors. 33 patients who fulfilled clinical criteria for severe sepsis or septic shock (SP) were prospectively enrolled study. A multiplex...
Background Omeprazole has recently been described as a modulator of tumour chemoresistance, although its underlying molecular mechanisms remain controversial. Since pancreatic tumours are highly chemoresistant, logical step would be to investigate the pharmacodynamic, morphological and biochemical effects omeprazole on cancer cell lines. Methodology/Principal Findings Dose-effect curves omeprazole, pantoprazole, gemcitabine, 5-fluorouracil combinations or gemcitabine were generated for lines...
Rikenella microfusus is an essential intestinal probiotic with great potential. The latest research shows that imbalance in the flora are related to occurrence of various diseases, such as immune and metabolic diseases. may be a target or biomarker for some providing new possibility preventing treating these diseases by monitoring optimizing abundance intestine. However, current methods have disadvantages, long detection times, complicated operations, high costs, which seriously limit...
Nonalcoholic fatty liver disease (NAFLD) is the most common pathology worldwide. In mice and humans, NAFLD progression characterized by appearance of TREM2-expressing macrophages in liver. However, their mechanistic contributions to have not been completely elucidated. Here, we show that TREM2+ prevent generation a pro-inflammatory response elicited LPS-laden lipoproteins vitro. Further, Trem2 expression regulates bone-marrow-derived (BMDMs) Kupffer cell capacity phagocyte apoptotic cells...