A5016589673- Mass Spectrometry Techniques and Applications
- Advanced Combustion Engine Technologies
- Radioactive contamination and transfer
- Radioactive element chemistry and processing
- Archaeology and ancient environmental studies
- Isotope Analysis in Ecology
- Nuclear Physics and Applications
- Folate and B Vitamins Research
- Carcinogens and Genotoxicity Assessment
- Forensic Anthropology and Bioarchaeology Studies
- Catalytic Processes in Materials Science
- Vehicle emissions and performance
- Chemical Synthesis and Characterization
- Paleopathology and ancient diseases
- Nuclear Materials and Properties
- Biodiesel Production and Applications
- Atmospheric chemistry and aerosols
- Nuclear reactor physics and engineering
- Forensic and Genetic Research
- Effects and risks of endocrine disrupting chemicals
- Metabolism and Genetic Disorders
- Advanced Proteomics Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Metabolomics and Mass Spectrometry Studies
- Air Quality and Health Impacts
Lawrence Livermore National Laboratory
2016-2025
Northwestern University
2024
Emissions Reduzierungs Concepte (Germany)
2017
University of California, Davis
1999-2015
Mayo Clinic in Arizona
2014
St. Michael's Hospital
2014
University of Iowa
2014
University of Toronto
2014
Heinrich Heine University Düsseldorf
2013-2014
Albert Einstein College of Medicine
2012
It has been difficult to establish whether we are limited the heart muscle cells born with or if cardiomyocytes generated also later in life. We have taken advantage of integration carbon-14, by nuclear bomb tests during Cold War, into DNA age humans. report that renew, a gradual decrease from 1% turning over annually at 25 0.45% 75. Fewer than 50% exchanged normal life span. The capacity generate adult human suggests it may be rational work toward development therapeutic strategies aimed...
Stem cells generate neurons in discrete regions the postnatal mammalian brain. However, extent of neurogenesis adult human brain has been difficult to establish. We have taken advantage integration (14)C, generated by nuclear bomb tests during Cold War, DNA establish age major areas cerebral neocortex. Together with analysis neocortex from patients who received BrdU, which integrates dividing cells, our results demonstrate that, whereas nonneuronal turn over, are not adulthood at detectable...
RETRACTION This article has been retracted: Circ Res . 2018;123:e00. DOI: 10.1161/RES.0000000000000247
Diabetes mellitus results from an absolute or relative deficiency of insulin-producing pancreatic β-cells. The turnover rate adult human β-cells remains unknown. We employed two techniques to examine islet β-cell and longevity in vivo.Subjects enrolled National Institutes Health clinical trials received thymidine analogs [iododeoxyuridine (IdU) bromodeoxyuridine (BrdU)] 8 d 4 yr prior death. Archival autopsy samples 10 patients (aged 17-74 yr) were assess by scoring nuclear analog labeling...
Two opposite views of cardiac growth are currently held; one the heart as a static organ characterized by large number cardiomyocytes that present at birth and live long organism, other highly plastic in which myocyte compartment is restored several times during course life.The average age cardiomyocytes, vascular endothelial cells (ECs), fibroblasts their turnover rates were measured retrospective (14)C dating 19 normal hearts 2 to 78 years 17 explanted failing 22 70 age. We report human...
Chronic exposure to arsenic (As) by drinking shallow groundwater causes widespread disease in Bangladesh and neighboring countries. The release of As naturally present sediment has been linked the reductive dissolution iron oxides coupled microbial respiration organic carbon (OC). source OC driving this reduction—carbon deposited with sediments or exogenous transported groundwater—is still debated despite its importance regulating aquifer redox status levels. Here, we used radiocarbon ( 14...
Summary . We present the application of a nonparametric method to performing functional principal component analysis for curve data that consist measurements random trajectory sample subjects. This design typically consists an irregular grid time points on which repeated are taken number introduce shrinkage estimates scores serve as effects in model. Scatterplot smoothing methods used estimate mean function and covariance surface this propose improved estimation neighborhood at diagonal...
Age determination of unknown human bodies is important in the setting a crime investigation or mass disaster because age at death, birth date, and year death as well gender can guide investigators to correct identity among large number possible matches. Traditional morphological methods used by anthropologists determine are often imprecise, whereas chemical analysis tooth dentin, such aspartic acid racemization, has shown reproducible more precise results. In this study, we analyzed teeth...
ABSTRACT: Radiocarbon dating, with special reference to the modern bomb‐curve, can provide useful information elucidate date of death skeletonized human remains. Interpretation be enhanced analysis different types tissues within a single skeleton because known variability formation times and remodeling rates. Analysis radiocarbon content teeth, especially enamel in tooth crowns, provides about childhood years consideration timing used estimate birth after 1950 ad . cortical trabecular bone...
AB Aquatic Biology Contact the journal Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 3:251-264 (2008) - DOI: https://doi.org/10.3354/ab00083 The invasive red alga Gracilaria vermiculophylla in Baltic Sea: adaptation brackish water may compensate for light limitation Florian Weinberger1,*, Björn Buchholz1, Rolf Karez2, Martin Wahl1 1Leibniz-Institut für Meereswissenschaften (IFM-GEOMAR), Düsternbrooker Weg 20, 24105...
In most countries today, obesity is increasing at an almost epidemic rate and creating a considerable public health problem by elevating the risk of cardiovascular disease metabolic disorders such as type 2 diabetes. It possible that, result, life expectancy will begin to decline in developed countries; this would be first occurrence recent history. Factors that influence fat mass adulthood remain incompletely understood, but increased lipid storage predeveloped cells, or adipocytes,...
Consumer goods contain multiwall carbon nanotubes (MWCNTs) that could be released during product life cycles into the environment, where their effects are uncertain. Here, we assessed MWCNT bioaccumulation in protozoan Tetrahymena thermophila via trophic transfer from bacterial prey (Pseudomonas aeruginosa) versus direct uptake growth media. The experiments were conducted using (14)C-labeled ((14)C-MWCNT) doses at or below 1 mg/L, which proved subtoxic since there no adverse on of test...
A summary is presented of experimental results obtained from a Cummins B5.9 175 hp, direct-injected diesel engine fueled with oxygenated blends. The oxygenates tested were dimethoxy methane (DMM), diethyl ether, blend monoglyme and diglyme, ethanol. show that particulate matter (PM) reduction controlled largely by the oxygen content fuel. For fuels tested, effect chemical structure was observed to be small. Isotopic tracer tests ethanol blends reveal carbon does contribute soot formation,...
Metabolites of atrazine were measured in human urine after dermal exposure using HPLC to separate and identify metabolites accelerator mass spectrometry (AMS) quantify them. Ring-labeled [14C]atrazine was applied for 24 h with a patch volunteers at low (0.167 mg, 6.45 muCi) high (1.98 24.7 doses. Urine collected 7 days. The centrifuged remove solids, the supernatant by liquid scintillation counting prior injection on ensure that < 0.17 Bq (4.5 pCi) injected column. A reversed-phase gradient...
Significance Tetramethylenedisulfotetramine (TETS) is a feared chemical threat agent because of its high convulsant toxicity, ease synthesis, and availability even though it banned as rodenticide. Earlier physiological evidence indicating action GABA receptor antagonist inhibitor [ 35 S]TBPS 3 H]EBOB binding confirmed here by radiosynthesis 14 C]TETS defining site in rat brain membranes accelerator mass spectrometry toxicant specificity studies on inhibition binding. TETS undergoes specific...
We present a sensitive tracer method, suitable for in vivo human research, that uses β-[14C]carotene coupled with accelerator mass spectrometry (AMS) detection. Using this approach, the concentration-time course of physiological (306 μg; 200 nCi) oral dose was determined 209 days plasma. Analytes included β-[14C]carotene, [14C]retinyl esters, [14C]retinol, and several [14C]retinoic acids. There 5.5-h lag between dosing appearance 14C Labeled β-carotene esters rose displayed maxima virtually...