A5102816205- Marine Sponges and Natural Products
- Genomics and Phylogenetic Studies
- Microbial Natural Products and Biosynthesis
- Diet and metabolism studies
- Gut microbiota and health
- biodegradable polymer synthesis and properties
- Tryptophan and brain disorders
- Microplastics and Plastic Pollution
- Enzyme Production and Characterization
- Microbial Community Ecology and Physiology
- Probiotics and Fermented Foods
- Plant Reproductive Biology
- Machine Learning in Healthcare
- Synthetic Organic Chemistry Methods
- Seed Germination and Physiology
- Wastewater Treatment and Nitrogen Removal
- Microbial Fuel Cells and Bioremediation
- Enterobacteriaceae and Cronobacter Research
- Bacteriophages and microbial interactions
- Clostridium difficile and Clostridium perfringens research
- Soybean genetics and cultivation
- Microbial Metabolic Engineering and Bioproduction
University College Cork
2018-2024
APC Microbiome Institute
2019-2021
National University of Ireland
2018
University of San Francisco
1993
Plastics, such as the polyethylene terephthalate (PET), are widely used for various industrial applications, due to their physicochemical properties which particularly useful in packaging industry. However, improper plastic waste management and difficulties recycling, post-consumer has become a pressing issue both environment human health. Hence, novel technologies methods of processing required address these issues. Enzymatic-assisted hydrolysis synthetic polymers been proposed potentially...
The genus Streptomyces produces secondary metabolic compounds that are rich in biological activity. Many of these genetically encoded by large metabolism biosynthetic gene clusters (smBGCs) such as polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS) which modular can be highly repetitive. Due to the repeats, difficult resolve using short read next generation datasets often quite poorly predicted standard approaches. We have sequenced genomes 13 spp. strains isolated from...
Recent studies demonstrate that a Mediterranean diet has beneficial metabolic effects in syndrome subjects. Since we have shown fecal microbiota transplantation (FMT) from lean donors exerts on insulin sensitivity, the present trial, investigated potential synergistic sensitivity of combining with donor FMT subjects syndrome.Twenty-four male were put and after 2-week run-in phase, randomized to either (n = 12) or autologous FMT. Changes gut composition bacterial strain engraftment dietary...
Dairy processing generates large volumes of wastewater that require extensive nutrient remediation prior to discharge. Significant commercial opportunities exist therefore for cost-effective biotechnologies capable achieving this requirement. In study the authors evaluated use intermittently aerated sequencing batch reactors, (IASBRs), as a single-tank biotreatment system co-removal COD, nitrogen and phosphorus from synthetic dairy wastewater. Variation IASBR aeration rates, (0.8, 0.6 0.4...
Much recent interest has arisen in investigating Streptomyces isolates derived from the marine environment search for new bioactive compounds, particularly those found association with invertebrates, such as sponges. Among these compounds recently identified are octapeptidic surugamides, which have been shown to possess anticancer and antifungal activities. By employing genome mining followed by an one strain many (OSMAC)-based approach, we previously unreported capability of a...
The emergence of antibiotic resistant microorganisms has led to an increased need for the discovery and development novel antimicrobial compounds. Frequent rediscovery same natural products (NPs) continues decrease likelihood new compounds from soil bacteria. Thus, efforts have shifted toward investigating their secondary metabolite biosynthesis potential, diverse niche environments, such as those isolated marine sponges. Here we investigated at genomic level two Streptomyces spp. strains,...
Streptomyces sp. strain SM8, isolated from Haliclona simulans, possesses antifungal and antibacterial activities inhibits the calcineurin pathway in yeast. The draft genome sequence is 7,145,211 bp, containing 5,929 predicted coding sequences. Several secondary metabolite biosynthetic gene clusters are present, encoding known novel metabolites, including antimycin.
Lifestyle, obesity and the gut microbiome are among most important risk factors for development of metabolic disorders. We demonstrate in 1,976 subjects a prospective population cohort (KORA) that specific microbiota members show 24-hour oscillations their relative abundance identified 13 taxa with disrupted rhythmicity T2D. Cross-validated prediction models based on this signature classified T2D an AUC 73%. BMI as independent factor improved classification The validity arrhythmic was...
ABSTRACT The complete genome sequence of the candidate probiotic strain Lactococcus lactis FNZ339 was determined using a hybrid assembly comprising data from Illumina and Oxford Nanopore Technologies sequencing platforms. comprised 2,673,297 bp, including circular chromosome four plasmids.
ABSTRACT The complete genome sequence of the candidate probiotic strain Lactiplantibacillus plantarum FNZ042 was determined using a hybrid assembly comprising data from Illumina and PacBio sequencing platforms. comprised 3,265,637 bp, including circular chromosome three plasmids.
Summary To combat the epidemic increase in Type-2-Diabetes (T2D), risk factors need to be identified. Diet, lifestyle and gut microbiome are among most important affecting metabolic health. We demonstrate 1,976 subjects of a prospective population cohort that specific microbiota members show diurnal oscillations their relative abundance we identified 13 taxa with disrupted rhythmicity T2D. Prediction models based on this signature classified T2D an area under curve 73%. BMI as...
Pseudomonas putida strain CA-3 is an industrial bioreactor isolate capable of synthesizing biodegradable polyhydroxyalkanoate polymers via the metabolism styrene and other unrelated carbon sources. The pathways involved are subject to regulation by global cellular processes. draft genome sequence 6,177,154 bp long contains 5,608 predicted coding sequences.
The rapid expansion of global plastic production in the last number decades (>355 million tonnes 2017), coupled with poor waste management, has resulted an estimated 5–12 metric entering our oceans. Packaging applications account for much current production, and commonly include polyethylene- polyethylene terephthalate (PET)-based materials that are resistant to natural degradation processes, particularly marine environments. In response this pollution issue continuing demand effective...