A5003697089- Advanced Proteomics Techniques and Applications
- Agricultural pest management studies
- Mass Spectrometry Techniques and Applications
- Genetic and Environmental Crop Studies
- Metabolomics and Mass Spectrometry Studies
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Bioinformatics and Genomic Networks
- Ovarian cancer diagnosis and treatment
- Identification and Quantification in Food
- Agronomic Practices and Intercropping Systems
- Peptidase Inhibition and Analysis
- Nematode management and characterization studies
- Genetics, Bioinformatics, and Biomedical Research
- Pesticide Residue Analysis and Safety
- Agricultural Science and Fertilization
- Plant Pathogens and Fungal Diseases
- Cancer and Skin Lesions
- Polyamine Metabolism and Applications
- Extracellular vesicles in disease
- Breast Lesions and Carcinomas
- Ubiquitin and proteasome pathways
- COVID-19 Clinical Research Studies
- Mycobacterium research and diagnosis
- Insect and Pesticide Research
Wrightington Hospital
2024-2025
Manipal University Jaipur
2025
Translational Health Science and Technology Institute
2015-2024
Vardhman Mahavir Medical College & Safdarjung Hospital
2016-2024
Banaras Hindu University
2016-2024
Michigan State University
2024
National Centre for Cell Science
2022-2024
Savitribai Phule Pune University
2011-2024
All India Institute of Medical Sciences
2024
Charles Darwin University
2022-2024
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the Golden Syrian hamster causes lung pathology that resembles human coronavirus disease (COVID-19). However, extrapulmonary pathologies associated with SARS-CoV-2 and post-COVID sequelae remain to be understood. Here, we show, using a model, early phase of leads an inflammatory response pathologies, while late cardiovascular complications (CVCs) characterized by ventricular wall thickening increased mass/body mass...
Plant species utilize a variety of regulatory mechanisms to ensure sustainable productivity. Within this intricate framework, numerous non-coding RNAs (ncRNAs) play crucial role in plant biology, surpassing the essential functions RNA molecules as messengers, ribosomal, and transfer RNAs. ncRNAs represent an emerging class regulators, operating directly form small interfering (siRNAs), microRNAs (miRNAs), long noncoding (lncRNAs), circular (circRNAs). These exert control at various levels,...
The genome sequencing of H37Rv strain <i>Mycobacterium tuberculosis</i> was completed in 1998 followed by the whole a clinical isolate, CDC1551 2002. Since then, genomic sequences number other strains have become available making it one better studied pathogenic bacterial species at level. However, annotation its remains challenging because high GC content and dissimilarity to model prokaryotes. To this end, we carried out an in-depth proteogenomic analysis <i>M. using Fourier transform mass...
Plasma is the most easily accessible source for biomarker discovery in clinical proteomics. However, identifying potential biomarkers from plasma a challenge given large dynamic range of proteins. The are generally present at very low abundance levels and hence identification these proteins necessitates depletion highly abundant Sample pre-fractionation using immuno-depletion high multi-affinity removal system (MARS) has been popular method to deplete multiple can result concomitant Although...
Abstract Compared to the clinical sector, prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in food sector is relatively low. However, their presence seafood a significant public health concern. In India, fish and fishery products are maximally manually handled compared other products. this study, 498 samples were collected under various conditions (fresh, chilled or dressed) representatives from surroundings. These screened for , determining its antimicrobial resistance, MRSA...
Introduction: Maffucci syndrome (MS) is a rare disorder with enchondromatosis associated multiple hemangiomas in soft tissue and internal organs. Enchondromas the long bone lead to limb length discrepancy, deformity, pathological fractures that usually need corrective osteotomies lengthening. Case Report: A female her late adolescence MS presented significant varus deformity of distal femur left lower shortening 11.5 cm. She underwent an acute correction osteotomy gradual femoral lengthening...
The passing of the Online Safety Act into law in October 2023 by parliament United Kingdom has brought back studies on impact technology cognitive development children, centre stage. With multiple showing an average screen time over 4 - 7 hours daily among children age group 8 18 globally, it is crucial that its long term be factored carefully before begins to entire generation adversely.
Objectives:: In laparoscopic appendicectomy, stump closure can be done by various methods such as endoloop, extracorporeal knots, intracorporeal ligatures, and gastrointestinal staplers. Polymeric clip was used in several studies the of appendicular because its lower cost easy implementation. The purpose this study is to investigate safety, usefulness, cost-effectiveness polymeric clips versus endoloop appendicectomy. Methods: We conducted a single blinded randomized controlled on 100...
Mass spectrometry has made rapid advances in the recent past and become preferred method for proteomics. Although many open source algorithms peptide identification exist, such as X!Tandem OMSSA, it majorly been a domain of proprietary software. There is need better, freely available, configurable that can help identifying correct peptides while keeping false positives to minimum. We have developed MassWiz, novel empirical scoring function gives appropriate weights major ions, continuity b-y...
Coronary artery disease (CAD) is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). The purpose present study was to discriminate Indian CAD or without T2DM by using multiple pathophysiological biomarkers.Using sensitive multiplex protein assays, we assessed 46 markers including cytokines/chemokines, metabolic hormones, adipokines apolipoproteins for evaluating different conditions control, T2DM, (T2DM_CAD). Network analysis performed create...
Sirtuins are protein deacetylases that play a protective role in cardiovascular diseases (CVDs), as well many other diseases. Absence of sirtuins can lead to hyperacetylation both nuclear and mitochondrial proteins leading metabolic dysregulation. The post-translational modifications (PTMs) known crosstalk among each bring about complex phenotypic outcomes. Various PTM types such acetylation, ubiquitination, phosphorylation, so on, drive transcriptional regulation metabolism, but crosstalks...
Abstract The study presented here aims at assessing the effects of hypobaric hypoxia on RAAS pathway and its components along with mitigation anomalies quercetin prophylaxis. One hour prior to exposure, male SD rats were orally supplemented (50 mg/kg BW) acetazolamide exposed them 25,000 ft. (7,620 m) in a simulated environmental chamber for 12 h 25 ± 2 °C. Different biochemical parameters like renin activity, aldosterone, angiotensin I, ACE determined plasma. As conventional response low...
We present GenoSuite, an integrated proteogenomic pipeline to validate, refine and discover protein coding genes using high-throughput mass spectrometry (MS) data from prokaryotes. To demonstrate the effectiveness of we analyzed proteomics Bradyrhizobium japonicum (USDA110), a model organism study agriculturally important rhizobium-legume symbiosis. Our analysis confirmed 31% known genes, refined 49 gene models for their translation initiation site (TIS) discovered 59 novel genes. Notably,...
Proteogenomic re-annotation and mRNA splicing information can lead to the discovery of various protein forms for eukaryotic model organisms like rat. However, detection novel proteoforms using mass spectrometry proteomics data remains a formidable challenge. We developed EuGenoSuite, an open source multiple algorithmic proteomic search tool utilized it in our in-house integrated transcriptomic-proteomic pipeline facilitate automated proteogenomic analysis. Using four pipelines (integrated...
Trypanosomiasis infects more than 21 million people and claims approximately 2 lives annually. Due to the development of resistance against currently available anti-trypanosomal drugs, there is a growing need for specific inhibitors novel drug targets. Of late, proteins from Ubiquitin Proteasome Pathway (UPP): ubiquitin ligases deubiquitinase have received attention as potential targets in other parasites apicomplexan family. The completion Trypanosoma cruzi (Tc) genome sequencing 2005...
Redox pathways play a key role in pathogenesis. Glutathione, central molecule redox homeostasis yeasts, is an essential metabolite, but its requirements can be met either from endogenous biosynthesis or the extracellular milieu. In this report we have examined importance of glutathione two major human opportunistic fungal pathogens, Candida albicans and glabrata. As genome sequence C. glabrata had suggested absence transporters, initially investigated exogenous utilization by disruption...