A5064765384- Advanced Proteomics Techniques and Applications
- Genomics and Phylogenetic Studies
- Metabolomics and Mass Spectrometry Studies
- Mosquito-borne diseases and control
- Bioinformatics and Genomic Networks
- Machine Learning in Bioinformatics
- Computational Drug Discovery Methods
- Malaria Research and Control
- Tuberculosis Research and Epidemiology
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Medicinal Plants and Neuroprotection
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Bacteriophages and microbial interactions
- Alzheimer's disease research and treatments
- Mycobacterium research and diagnosis
- MicroRNA in disease regulation
- Invertebrate Immune Response Mechanisms
- Insect symbiosis and bacterial influences
- Cancer Mechanisms and Therapy
- S100 Proteins and Annexins
Yenepoya University
2016-2025
Center for Systems Biology
2015-2025
Institute of Bioinformatics
2013-2023
Amrita Vishwa Vidyapeetham
2011-2023
Mangalore University
2022
Centre for Cellular and Molecular Biology
2022
National Institute of Mental Health and Neurosciences
2014-2021
RMIT University
2021
Manipal Academy of Higher Education
2011-2018
Pondicherry University
2010-2017
Human Protein Reference Database (HPRD--http://www.hprd.org/), initially described in 2003, is a database of curated proteomic information pertaining to human proteins. We have recently added number new features HPRD. These include PhosphoMotif Finder, which allows users find the presence over 320 experimentally verified phosphorylation motifs proteins interest. Another feature protein distributed annotation system--Human Proteinpedia (http://www.humanproteinpedia.org/)--through laboratories...
Extracellular vesicles (EVs) are membraneous released by a variety of cells into their microenvironment. Recent studies have elucidated the role EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, as possible reservoirs biomarkers. These findings generated immense interest, along with an exponential increase molecular data pertaining to EVs. Here, we describe Vesiclepedia, manually curated compendium (lipid, RNA, protein) identified different classes...
Abstract We have developed NetPath as a resource of curated human signaling pathways. As an initial step, provides detailed maps number immune pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances transcriptionally regulated genes - all linked to over 5,500 published articles. anticipate become consolidated for pathways that should enable systems biology approaches.
Plasma Proteome Database (PPD; http://www.plasmaproteomedatabase.org/) was initially described in the year 2005 as a part of Human Organization's (HUPO's) pilot initiative on Project. Since then, improvements proteomic technologies and increased throughput have led to identification large number novel plasma proteins. To keep up with this increase data, we significantly enriched information PPD. This database currently contains 10 546 proteins detected serum/plasma which 3784 been reported...
Synthetic lethal genetic interaction networks define genes that work together to control essential functions and have been studied extensively in Saccharomyces cerevisiae using the synthetic array (SGA) analysis technique (ScSGA). The extent which or other are conserved between species remains uncertain. To address this question, we compared literature-curated experimentally derived for two distantly related yeasts, Schizosaccharomyces pombe S. cerevisiae. We find 23% of interactions a...
Rheumatoid arthritis and osteoarthritis are two common musculoskeletal disorders that affect the joints. Despite high prevalence rates, etiological factors involved in these remain largely unknown. Dissecting molecular aspects of will significantly contribute to improving their diagnosis clinical management. In order identify proteins differentially expressed between conditions, a quantitative proteomic profiling synovial fluid obtained from rheumatoid patients was carried out by using iTRAQ...
Osteoarthritis is a chronic musculoskeletal disorder characterized mainly by progressive degradation of the hyaline cartilage. Patients with osteoarthritis often postpone seeking medical help, which results in diagnosis being made at an advanced stage cartilage destruction. Sustained efforts are needed to identify specific markers that might help early diagnosis, monitoring disease progression and improving therapeutic outcomes. We employed multipronged proteomic approach, included multiple...
The vitreous humor is a transparent, gelatinous mass whose main constituent water. It plays an important role in providing metabolic nutrient requirements of the lens, coordinating eye growth and support to retina. close proximity retina reflects many changes occurring this tissue. biochemical could provide better understanding about pathophysiological processes that occur vitreoretinopathy. In study, we investigated proteome normal human using high resolution Fourier transform...
The genome sequencing of H37Rv strain <i>Mycobacterium tuberculosis</i> was completed in 1998 followed by the whole a clinical isolate, CDC1551 2002. Since then, genomic sequences number other strains have become available making it one better studied pathogenic bacterial species at level. However, annotation its remains challenging because high GC content and dissimilarity to model prokaryotes. To this end, we carried out an in-depth proteogenomic analysis <i>M. using Fourier transform mass...
Esophageal squamous cell carcinoma (ESCC) is among the top ten most frequent malignancies worldwide. In this study, our objective was to identify potential biomarkers for ESCC through a quantitative proteomic approach using isobaric tags relative and absolute quantitation (iTRAQ) approach. We compared protein expression profiles of tumor tissues with corresponding adjacent normal tissue from patients. LC-MS/MS analysis strong cation exchange chromatography fractions carried out on an...
Polycystic ovary syndrome (PCOS), a major cause of anovulatory infertility, is characterized by arrested follicular growth. Altered protein levels in the fluid surrounding ovum may reflect molecular defects folliculogenesis these women.To identify differentially regulated proteins PCOS comparing repertoire with healthy women.The samples were collected from and normo-ovulatory women undergoing vitro fertilization. Follicular subjected to digestion using trypsin, resultant peptides labeled...
Calcium Dependent Protein Kinases are key effectors of calcium signaling in malaria parasite. PfCDPK1 is critical for asexual development Plasmodium falciparum, but its precise function and substrates remain largely unknown. Using a conditional knockdown strategy, we here establish that this kinase the invasion host erythrocytes. Furthermore, using multidisciplinary approach involving comparative phosphoproteomics gain insights into underlying molecular mechanisms. We identify PfCDPK1, which...
Plasma is one of the best studied compartments in human body and serves as an ideal fluid for diagnosis diseases. This report provides a detailed functional annotation all plasma proteins identified to date. In all, gene products encoded by 3778 distinct genes were annotated based on previously published literature identification multiple peptides from under HUPO's Proteome Project. Our analysis revealed that 51% these more than protein isoform. All single nucleotide polymorphisms involving...
Cancer of the esophagus is two main types, each with distinct etiological and pathological characteristics. Esophageal squamous cell carcinoma (ESCC) predominant type esophageal cancers worldwide comprising almost 95% cases. While ESCC prevalent in developing world, adenocarcinoma commonly seen developed country, usually association Barrett's esophagus. In spite its higher prevalence, has not been studied as intensively adenocarcinoma. are common poor survival rate among patients mainly...