A5012806499- Pituitary Gland Disorders and Treatments
- Advanced Proteomics Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Tuberculosis Research and Epidemiology
- Biochemical and Molecular Research
- Growth Hormone and Insulin-like Growth Factors
- Ovarian function and disorders
- Circadian rhythm and melatonin
- Fungal Infections and Studies
- HIV Research and Treatment
- Toxoplasma gondii Research Studies
- Cancer therapeutics and mechanisms
- Toxic Organic Pollutants Impact
- Neuroendocrine Tumor Research Advances
- Insect symbiosis and bacterial influences
- Sperm and Testicular Function
- GABA and Rice Research
- Salmonella and Campylobacter epidemiology
- Machine Learning in Bioinformatics
- Thyroid Cancer Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Meningioma and schwannoma management
- Phytoplasmas and Hemiptera pathogens
- Genomics, phytochemicals, and oxidative stress
- Herpesvirus Infections and Treatments
Institute of Bioinformatics
2013-2022
Indian Institute of Science Bangalore
2021-2022
KIIT University
2014-2017
Bangalore University
2015-2016
Science & Technology Park (Czechia)
2015-2016
Complementing genome sequence with deep transcriptome and proteome data could enable more accurate assembly annotation of newly sequenced genomes. Here, we provide a proof-of-concept an integrated approach for analysis the Anopheles stephensi, which is one most important vectors malaria parasite. To achieve broad coverage genes, carried out sequencing profiling multiple anatomically distinct sites. Based on transcriptomic alone, identified corrected 535 events incomplete involving 1196...
Polycystic ovary syndrome (PCOS) is a complex endocrinopathy affecting women of reproductive age, and whose etiology not well understood yet. In these women, the follicular growth arrested at preantral stage leading to cyst formation, consequently resulting in anovulatory infertility women. As fluid provides conducive microenvironment for oocytes, molecular profiling may provide unique information about pathophysiology associated with development PCOS. Post-translational addition...
Toxoplasma encephalitis is caused by the opportunistic protozoan parasite gondii. Primary infection with T. gondii in immunocompetent individuals remains largely asymptomatic. In contrast, immunocompromised individuals, reactivation of results severe complications and mortality. Molecular changes at protein level host central nervous system proteins associated pathogenesis toxoplasma are unexplored. We used a global quantitative proteomic strategy to identify differentially regulated...
The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within pituitary. Although hormones secreted from have been well studied, comprehensive analyses of proteome are limited. Pituitary proteomics field postgenomic research that crucial to understand human health diseases. In this context, we report here systematic proteomic profiling anterior gland (adenohypophysis) using high-resolution Fourier transform mass spectrometry. A total 2164...
We employed a high-resolution mass spectrometry-based approach to characterize the proteome of human pineal gland.
Brain proteome profile of cryptococcal meningitis co-infected with HIV.
Salmonella Enteritidis causes food-borne gastroenteritis by the two type three secretion systems (TTSS). TTSS-1 mediates invasion through intestinal lining, and TTSS-2 facilitates phagocytic survival. The pathogens' ability to infect effectively under TTSS-1-deficient background in host's phagocytes is poorly understood. Therefore, pathobiological understanding of TTSS-1-defective nontyphoidal Salmonellosis highly important. We performed a comparative global proteomic analysis isogenic...
has been infecting millions of people worldwide over the years, causing tuberculosis. Drugs targeting distinct cellular mechanisms including synthesis cell wall, lipids, proteins, and nucleic acids in
Mycobacterium tuberculosis (Mtb) is considered to be a devastating pathogen worldwide, affecting millions of people globally. Several drugs targeting distinct pathways are utilized for the treatment tuberculosis. Despite monumental efforts being directed at discovery Mtb, has also developed mechanisms evade drug action and host processes. Rifampicin was an early anti-tuberculosis drug, still used as first line treatment. This study carried out in order characterize in-depth...
Abstract Non-functioning pituitary tumours (NF-PitNETs) are common intracranial benign neoplasms that can exhibit aggressive behaviour by invading neighbouring structures and, in some cases, have multiple recurrences. Despite resulting severe co-morbidities, no predictive biomarkers of recurrence been identified for NF-PitNETs. In this study we used high-throughput mass spectrometry-based analysis to examine the phosphorylation pattern different subsets Based on histopathological,...
Polycystic ovary syndrome (PCOS) is a common and heterogeneous disorder, affecting women at reproductive age.Follicular growth arrested in PCOS leading to cysts formation anovulation.Follicular fluid produced the growing antral follicles provides micro-environment for developing oocyte contains several factors including proteins, steroids, polysaccharides, metabolites that modulate developmental competence ovulation.Our earlier study on comparative proteomics of follicular (FF) has revealed...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Background NFPTs are the most common operated pituitary tumours and can present with visual field defects, hormone deficiencies headache. Surgery is treatment of choice but recurrence rate high ranging from 10-50%, depending on extent tumour removal. No confirmed predictive biomarkers for NFPT have been identified, apart Ki-67. We applied high-throughput mass spectrometry-based phosphoproteomic approach to explore phosphorylation pattern proteins in order identify markers invasion...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)