A5018605685- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Advanced Proteomics Techniques and Applications
- Cytokine Signaling Pathways and Interactions
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- MicroRNA in disease regulation
- Virology and Viral Diseases
- Machine Learning in Bioinformatics
- Toxin Mechanisms and Immunotoxins
- Metabolomics and Mass Spectrometry Studies
- Chronic Lymphocytic Leukemia Research
- Cancer-related molecular mechanisms research
- Botany, Ecology, and Taxonomy Studies
- RNA and protein synthesis mechanisms
- Angiogenesis and VEGF in Cancer
- Botanical Research and Chemistry
- Peptidase Inhibition and Analysis
- Microtubule and mitosis dynamics
- Protein Kinase Regulation and GTPase Signaling
- Glycosylation and Glycoproteins Research
- vaccines and immunoinformatics approaches
- Insect symbiosis and bacterial influences
Yenepoya University
2021-2025
Rajiv Gandhi Centre for Biotechnology
2014-2020
Louis Stokes Cleveland VA Medical Center
2016
Institute of Bioinformatics
2009-2015
Science & Technology Park (Czechia)
2013-2014
Kuvempu University
2008-2012
Johns Hopkins University
2009-2011
Savitribai Phule Pune University
2011
Pondicherry University
2011
Manipal Academy of Higher Education
2011
Human Protein Reference Database (HPRD--http://www.hprd.org/), initially described in 2003, is a database of curated proteomic information pertaining to human proteins. We have recently added number new features HPRD. These include PhosphoMotif Finder, which allows users find the presence over 320 experimentally verified phosphorylation motifs proteins interest. Another feature protein distributed annotation system--Human Proteinpedia (http://www.humanproteinpedia.org/)--through laboratories...
Abstract We have developed NetPath as a resource of curated human signaling pathways. As an initial step, provides detailed maps number immune pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances transcriptionally regulated genes - all linked to over 5,500 published articles. anticipate become consolidated for pathways that should enable systems biology approaches.
Plasma Proteome Database (PPD; http://www.plasmaproteomedatabase.org/) was initially described in the year 2005 as a part of Human Organization's (HUPO's) pilot initiative on Project. Since then, improvements proteomic technologies and increased throughput have led to identification large number novel plasma proteins. To keep up with this increase data, we significantly enriched information PPD. This database currently contains 10 546 proteins detected serum/plasma which 3784 been reported...
Signaling pathways are orchestrated by post-translational modifications (PTMs) such as phosphorylation. However, pathway analysis of PTM data sets generated mass spectrometry (MS)-based proteomics is typically performed at a gene-centric level because the lack appropriately curated signature databases and bioinformatic tools that leverage site-specific information. Here we present first version PTMsigDB, database modification signatures perturbations, kinase activities signaling from more...
Rheumatoid arthritis and osteoarthritis are two common musculoskeletal disorders that affect the joints. Despite high prevalence rates, etiological factors involved in these remain largely unknown. Dissecting molecular aspects of will significantly contribute to improving their diagnosis clinical management. In order identify proteins differentially expressed between conditions, a quantitative proteomic profiling synovial fluid obtained from rheumatoid patients was carried out by using iTRAQ...
Osteoarthritis is a chronic musculoskeletal disorder characterized mainly by progressive degradation of the hyaline cartilage. Patients with osteoarthritis often postpone seeking medical help, which results in diagnosis being made at an advanced stage cartilage destruction. Sustained efforts are needed to identify specific markers that might help early diagnosis, monitoring disease progression and improving therapeutic outcomes. We employed multipronged proteomic approach, included multiple...
Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays critical role in the regulation of immune responses and differentiation hematopoietic cells. TSLP signals through heterodimeric receptor complex consisting an interleukin-7 α chain unique (TSLPR) [also known as receptor-like factor 2 (CRLF2)]. Cellular targets include dendritic cells, B mast regulatory T (Treg) cells CD4+ CD8+ The TSLP/TSLPR axis can activate multiple signaling transduction pathways including...
Abstract Background Dye-sensitized solar cells (DSSCs) have garnered a lot of attention in recent years. The energy to power conversion efficiency DSSC is influenced by various components the cell such as dye, electrolyte, electrodes and additives among others leading varying experimental configurations. A large number metal-based metal-free dye sensitizers now been reported tools using data indicate new directions for design development are on rise. Description DSSCDB, first its kind...
The three La Crosse virus genomes are found as circular structures in the electron microscope, and RNA ends of at least small (S) medium (M) segments highly complementary. When examined for psoralen cross-linking, about half S, most 1 to 2% M, none large (L) nucleocapsid RNAs could be cross-linked virions or late times intracellularly, under conditions which each free reacted completely. For S segment, antigenomes first detected intracellularly not all, their cross-linkability increased...
Four types of Sindbis virus vectors, each carrying two promoters for subgenomic mRNA synthesis, were designed to measure relative promoter strengths and survey potential contextual effects on strengths. One the in vector was used as reference promoter, while other one being tested. We these vectors four promoters: minimal an extended sequence believed have full activity, mutant promoters, with inactivating 3-nucleotide insertion called CR4.1 a 4-nucleotide deletion delta 4. The measured by...