A5034046625- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- COVID-19 epidemiological studies
- Adsorption and biosorption for pollutant removal
- Bacteriophages and microbial interactions
- Nanomaterials for catalytic reactions
- Cancer-related molecular mechanisms research
- SARS-CoV-2 detection and testing
- Pneumonia and Respiratory Infections
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Toxin Mechanisms and Immunotoxins
- SARS-CoV-2 and COVID-19 Research
- Bacterial Genetics and Biotechnology
- MicroRNA in disease regulation
- Infection Control and Ventilation
- Long-Term Effects of COVID-19
- Genetic and Environmental Crop Studies
- Legume Nitrogen Fixing Symbiosis
- Mathematical and Theoretical Epidemiology and Ecology Models
- Escherichia coli research studies
- COVID-19 Clinical Research Studies
- Genomics and Phylogenetic Studies
- Biochemical and Molecular Research
- Agricultural Economics and Practices
Manipal Academy of Higher Education
2023-2024
Institute of Bioinformatics
2013-2024
Stanford University
2019-2024
Govind Ballabh Pant Hospital
2021-2023
Central Council for Research in Homoeopathy
2022
Central Research Institute
2022
Barkatullah University
2022
Dr. BMN College of Home Science
2022
Guru Gobind Singh Indraprastha University
2018-2021
Indian Institute of Pulses Research
2020-2021
Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet underlying mechanism unknown. To explore whether severe acute respiratory syndrome 2 (SARS-CoV-2) infection tissue contributes to pathogenesis, we evaluated COVID-19 autopsy cases and deeply profiled response SARS-CoV-2 in vitro. In cases, identified RNA adipocytes an inflammatory infiltrate. We two distinct cellular targets infection: a...
Complementing genome sequence with deep transcriptome and proteome data could enable more accurate assembly annotation of newly sequenced genomes. Here, we provide a proof-of-concept an integrated approach for analysis the Anopheles stephensi, which is one most important vectors malaria parasite. To achieve broad coverage genes, carried out sequencing profiling multiple anatomically distinct sites. Based on transcriptomic alone, identified corrected 535 events incomplete involving 1196...
The presence of chromium in aquatic streams due to the discharge industrial effluents is great concern because its toxic nature. Removal Cr(VI) ion from wastewater a necessary task. To enhance adsorption capacity sawdust for heavy metals, was modified with formaldehyde and used metal Cr(VI). process modifying characterised by Fourier Transform Infrared Spectroscopy (FTIR) Scanning Electron Microscopy (SEM). effects various parameters such as pH, contact time, adsorbent dose initial...
Whole genome sequencing (WGS) of Mycobacterium tuberculosis has been constructive in understanding its evolution, genetic diversity and the mechanisms involved drug resistance. A large number efforts from across globe have revealed among clinical isolates determinants for their resistance to anti-tubercular drugs. Considering high TB burden India, availability WGS studies is limited. Here we present, results 200 M. North India which are categorized as sensitive first-line drugs,...
Standardized dosing of antitubercular drugs leads to variable plasma drug levels, which are associated with adverse reactions, delayed treatment response, and relapse. Mutations in genes affecting metabolism explain considerable interindividual pharmacokinetic variability; however, pharmacogenomic assays that predict have been lacking.
Mycobacterium tuberculosis, the causative agent of accounts for 1.5 million human deaths annually worldwide. Despite efforts to eradicate it still remains a deadly disease. The two best characterized strains M. virulent H37Rv and avirulent H37Ra, provide unique platform investigate biochemical signaling pathways associated with pathogenicity. To delineate biomolecular dynamics that may account pathogenicity attenuation virulence in we compared proteome phosphoproteome profiles H37Ra strains....
BackgroundThere is a need to identify scalable tuberculosis screening strategies among high burden populations. The WHO has identified non-sputum-based triage test as development priority.MethodsWe performed diagnostic case-control study of point-of-care C-reactive protein (CRP) and Prototype-Xpert-MTB-Host-Response (Xpert-MTB-HR) assays in the context mass program for two prisons Brazil. All incarcerated individuals irrespective symptoms were screened by sputum Xpert MTB/RIF culture. Among...
Abstract Background Given the persistence of viral RNA in clinically recovered coronavirus disease 2019 (COVID-19) patients, subgenomic RNAs (sgRNAs) have been reported as potential molecular viability markers for severe acute respiratory syndrome 2 (SARS-CoV-2). However, few data are available on their longitudinal kinetics, compared with genomic (gRNA), clinical samples. Methods We analyzed 536 samples from 205 patients COVID-19 placebo-controlled, outpatient trials peginterferon Lambda-1a...
Purified protein derivative (PPD) has been used for more than half a century as an antigen the diagnosis of tuberculosis infection based on delayed type hypersensitivity. Although designated "purified," in reality, composition PPD is highly complex and remains ill-defined. In this report, high resolution mass spectrometry was applied to understand complexity its constituent components. A comparative proteomic analysis various preparations their functional characterization likely help...
Abstract The cheap and easy availability of the Kinnow peel waste has reported various applications due to presence multifunctional groups. Therefore, in present study we explored its application synthesize N-Benzylideneaniline derivatives based on Schiff base reaction. powder is characterized by FTIR, TEM, SEM, XRD, EDX, TGA for functional groups, morphology, surface, elements thermal stability. Benzaldehyde, aniline, their such as 4-methyl benzaldehyde, 4-hydroxy 4-methoxy aniline have...
Removal of alizarin red S (ARS) and Indigo dye from aqueous media reduction nitro aromatic compounds are successfully done under mild condition by using reduced Graphene Oxide-Nickel Oxide (rGO-NiO) nanocomposite as catalyst. RGO-NiO is well characterized different analytical techniques. Morphology, structural, composition studies HRTEM, FESEM, EDX, TGA, FTIR, XPS, Raman spectroscopy, XRD. has high stability for the removal ARS, dye, reaction compounds.
The feasibility of using eco-friendly biodegradable arginine functionalized magnetic nanoparticle entrapped chitosan beads (AFMNPECBs) for simultaneous removal three metal ions from water samples was evaluated under different conditions.
Summary Silver nanoparticle entrapped calcium‐alginate beads (AgNP‐CAB) were successfully synthesized as adsorbent for effective removal of Fe(II) ions from aqueous solution. The was characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), X‐ray diffraction (XRD) and thermogravimetric analysis (TGA). Batch adsorption experiments used to determine the capacity. influence various factors (such temperature, pH, dosage contact time) on behaviour...
Abstract The COVID-19 pandemic, caused by the viral pathogen SARS-CoV-2, has taken lives of millions individuals around world. Obesity is associated with adverse outcomes, but underlying mechanism unknown. In this report, we demonstrate that human adipose tissue from multiple depots permissive to SARS-CoV-2 infection and elicits an inflammatory response, including secretion known mediators severe COVID-19. We identify two cellular targets in tissue: mature adipocytes macrophages. Adipose...