A5074355987- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Ocular Oncology and Treatments
- Glaucoma and retinal disorders
- Sphingolipid Metabolism and Signaling
- Cancer, Lipids, and Metabolism
- Corneal surgery and disorders
- GABA and Rice Research
- Metabolomics and Mass Spectrometry Studies
- Lipid Membrane Structure and Behavior
- RNA modifications and cancer
- Food composition and properties
- Plant responses to elevated CO2
- Erythrocyte Function and Pathophysiology
- Advanced Measurement and Detection Methods
- Ion channel regulation and function
- Ubiquitin and proteasome pathways
- Cell Image Analysis Techniques
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Ocular Surface and Contact Lens
- Thyroid Cancer Diagnosis and Treatment
- Nicotinic Acetylcholine Receptors Study
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Biosensing Techniques and Applications
Manipal Academy of Higher Education
2022-2025
Institute of Bioinformatics
2015-2025
Agilent Technologies (India)
2015-2022
Agilent Technologies (United States)
2015
University Hospital of Basel
2014
Resonance Research (United States)
2014
University of Basel
2014
T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity potential antileukemia effects. We report self-reactive a novel class self-lipids, identified as methyl-lysophosphatidic acids (mLPAs), which accumulated leukemia cells. Primary acute myeloid B cell blasts express CD1 molecules. mLPA-specific efficiently CD1c+ poorly nontransformed...
Uncontrolled growth of breast cells due to altered gene expression is a key feature cancer. Alterations in the ion channels lead variations cellular activities, thus contributing attributes cancer hallmarks. Changes levels were observed as consequence EMT. Additionally, reported activation EMT and maintenance mesenchymal phenotype. Here, identify patients, differential weighted co-expression network analyses performed using transcriptomic data. Protein-protein interactions analysis was...
Here, we present an update on the next level of experiments studying impact gamma radiation environment, created post-March, 2011 nuclear accident at Fukushima Daiichi power plant, rice plant and its generation—the seed. Japonica-type (Oryza sativa L. cv. Koshihikari) was exposed to low-level (~4 μSv/h) in contaminated Iitate Farm field village (Fukushima). Seeds were harvested from these plants maturity, serve as treated group. For control group, seeds (cv. grown clean soil Soma city,...
Esophageal squamous cell carcinoma (ESCC) is the most prevalent malignant gastrointestinal tumor. Ion channels contribute to tumor growth and progression through interactions with their neighboring molecules including lipids. The dysregulation of membrane ion lipid metabolism may epithelial-mesenchymal transition (EMT), leading metastatic progression. Herein, transcriptome profiles patients ESCC were analyzed by performing differential gene expression weighted co-expression network analysis...
Keratoconus is an etiologically complex, degenerative corneal disease that eventually leads to loss of integrity. Cells in epithelium and endothelium express various types ion channels play important roles ocular pathology. This emphasizes the need understanding alterations keratoconus.
Retinoblastoma is a pediatric eye cancer affecting children usually less than five years of age. Inactivation both the copies RB1 gene in child's retina initiates formation. While lot literature exists regarding pathogenesis and genetic changes retinoblastoma, there still lack revelation specific progression markers correlation expression with disease mechanism. In this study, we aim to determine transcriptomic, metabolomic proteomic profile from different sample types viz. tissue, aqueous...
Abstract Metabolic dysfunction or reprogramming is the underlying cause of many diseases including cancer. In this study, we looked into transcriptomic and metabolomic profile retinoblastoma (Rb), a pediatric eye cancer, from tumor normal tissue, aqueous humor, vitreous humor tear. The samples were collected enucleated eyes 9 subjects 2 deceased controls, whose death not due to any related disease. study was corroborated with cell line models retinoblastoma, used for metabolic phenotyping....
Abstract This study illustrates a multi-omics approach combining transcriptomics and metabolomics datasets to molecular events leading progression of retinoblastoma. Retinoblastoma is pediatric ocular cancer affecting children usually less than five years age. It complex disease predisposed primarily by biallelic inactivating mutations in the RB1 gene. gene has essential roles cell cycle, differentiation, chromosome stability implicated other functions. From cohort 9 patients undergoing...
Purpose a) Elucidate the differential expression profiles in tumors & invitro models. b) Identify novel signal transductions and key regulators retinoblastoma. Methods Institutional Ethics Committee approval was obtained prior to sample collection. We used enucleated eyes of 9 case samples 2 pediatric deceased controls. Total RNA extracted from tumor control retina for mRNA, miRNA microarray RT-PCR gene validation tumors. Patient's aqueous, vitreous tears were analysed by LC/GC-MS validate...
Cancer cells, unlike in normal cells exhibit altered metabolic activity especially with respect to oxidative phosphorylation (OXPHOS) and glucose metabolism. In this study, we looked into the transcriptomics metabolomics profile of retinoblastoma, a pediatric eye cancer from different sample types viz. tissue, aqueous humor, vitreous humor tear. The samples were collected enucleated eyes 9 patients 2 deceased controls, whose cause death is not due any related disease. There are 5 males 4...