A5100337948- Autophagy in Disease and Therapy
- Photonic Crystals and Applications
- Microtubule and mitosis dynamics
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Plasmonic and Surface Plasmon Research
- Electromagnetic Fields and Biological Effects
- Photonic and Optical Devices
- Metamaterials and Metasurfaces Applications
- Glaucoma and retinal disorders
- NF-κB Signaling Pathways
- Sports Performance and Training
- Adenosine and Purinergic Signaling
- Neuroscience of respiration and sleep
- Advanced Antenna and Metasurface Technologies
- Intraocular Surgery and Lenses
- Obstructive Sleep Apnea Research
- Acupuncture Treatment Research Studies
- Cancer, Lipids, and Metabolism
- Influenza Virus Research Studies
- Cannabis and Cannabinoid Research
- Dermatology and Skin Diseases
- Pain Mechanisms and Treatments
- Winter Sports Injuries and Performance
Shihezi University
2022-2024
MRC Protein Phosphorylation and Ubiquitylation Unit
2021-2024
University of Dundee
2021-2024
Medical Research Council
2021-2024
Gansu University of Traditional Chinese Medicine
2024
Tsinghua University
2023-2024
Gansu Provincial Maternal and Child Health Hospital
2024
Beijing University of Chinese Medicine
2024
Ocean University of China
2024
The University of Sydney
2024
Silver nanobars with rectangular side facets and an average aspect ratio of 2.7 have been synthesized by modifying the concentration bromide added to a polyol synthesis. Subsequent rounding transformed them into nanorice. Due their anisotropy, nanorice exhibit two plasmon resonance peaks, scattering light both in visible near-infrared regions. With combination discrete-dipole approximation calculations single-nanoparticle spectroscopy, we explored effect nanostructure corner sharpness on...
Metal nanoparticles have received increasing attention for their peculiar capability to control local surface plasmon resonance (SPR) when interacting with incident light waves. In this article, we calculate the optical extinction spectra of silver nanocubes edge length ranging from 15 200 nm by using discrete dipole approximation method. An number SPR peaks appear in spectra, and positions change nanocube size increases. We developed a method quantitatively separate contributions individual...
Background: Acute lung injury (ALI) is a leading cause of mortality in patients with sepsis due to proinflammatory endothelial changes and permeability defects. Mitochondrial dysfunction recognized as critical mediator the pathogenesis sepsis-induced ALI. Although mitophagy regulation mitochondrial quality well recognized, little known about its role ECs during Sirtuin 1 (SIRT1) histone protein deacetylase involved inflammation, mitophagy, cellular senescence. Here, authors show type late...
The goal of automatic report generation is to generate a clinically accurate and coherent phrase from single given X-ray image, which could alleviate the workload traditional radiology reporting. However, in real-world scenario, radiologists frequently face challenge producing extensive reports derived numerous medical images, thereby multi-image perspective needed. In this paper, we propose Complex Organ Mask Guided (termed as COMG) model, incorporates masks multiple organs (e.g., bones,...
Benzalkonium chloride (BAC) is the most common preservative in ophthalmic preparations. Here, we investigated corneal alternations rabbits following exposure to BAC. Twenty-four adult male New Zealand albino were randomly divided into three groups. BAC at 0.01%, 0.05%, or 0.1% was applied twice daily one eye each of for 4 days. The contralateral untreated eyes used as control. Aqueous tear production and fluorescein staining scores BAC-treated compared with those controls. structure central...
T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity potential antileukemia effects. We report self-reactive a novel class self-lipids, identified as methyl-lysophosphatidic acids (mLPAs), which accumulated leukemia cells. Primary acute myeloid B cell blasts express CD1 molecules. mLPA-specific efficiently CD1c+ poorly nontransformed...
Purified microtubules have been shown to align along the static magnetic field (SMF) in vitro because of their diamagnetic anisotropy. However, whether mitotic spindle cells can be aligned by has not experimentally proved. In particular, biological effects SMF above 20 T (Tesla) never reported. Here we found that both CNE-2Z and RPE1 human orients 27 SMF. The direction alignment depended on extent which chromosomes were form a planar metaphase plate. Our results show torque acts chromosomes,...
Chronic neuroinflammation is thought to play an etiological role in Alzheimer's disease (AD) which characterized pathologically by amyloid and tau formation, as well neuritic dystrophy synaptic degeneration. The causal relationship between these pathological events a topic of ongoing research discussion. Recent data from transgenic AD models point tight spatio-temporal link pathology, with the obligatory enzyme for β-amyloid (Aβ) production, namely β-secretase-1 (BACE1), being overexpressed...
Unc-51-like autophagy activating kinase 1 (ULK1)–autophagy-related 13 (ATG13) is the most upstream initiation complex that phosphorylated by mammalian target-of-rapamycin (mTORC1) and AMP-activated protein (AMPK) to induce in asynchronous conditions. However, their phospho-regulation functions mitosis cell cycle remain unknown. Here we show ULK1-ATG13 differentially regulated throughout cycle, especially mitosis, which both ULK1 ATG13 are highly key machinery cyclin-dependent (CDK1)/cyclin...
Recently, negative refraction of electromagnetic waves in photonic crystals was demonstrated experimentally and subwavelength images were observed. However, these investigations all focused on the periodic structure. Here, we report a new theoretical experimental finding that can appear some transparent quasicrystalline structures. The quasicrystals (PQCs) exhibit an effective refractive index close to $\ensuremath{-}1$ certain frequency window. shows small spatial dispersion, consistent...
The influence of natural regulatory T cells (nTregs) on the patients with colon cancer is unclear. Demethylated status Treg-specific demethylated region (TSDR) FOXP3 gene was reported to be a potential biomarker for identification nTregs. demethylation rate TSDR (TSDR-DMR) calculated by using methylation-specific quantitative polymerase chain reaction (MS-qPCR) assay. expression TSDR-DMR and mRNA investigated in various colorectal cell lines. A total 130 carcinoma samples were utilized study...
The prediction of side-effects is a key issue in the REACH initiative on chemicals preclinical testing drugs. dermal irritation and skin sensitization toxicity potential new molecule, vitacoxib, were invested rabbits guinea pigs compliance with Organization for Economic Cooperation Development guideline. To assess irritation, dermally attached to vitacoxib 72 h or repeated application. results showed that no adverse reactions such as erythema edema observed throughout test. In test,...
Intermittent fasting (IF) is a convenient dietary intervention for multiple diseases, including type 2 diabetes. However, whether it can be used as long-term antidiabetic approach still unknown. Here, we confirm that IF alone beneficial both moderate and severe diabetic mice, but its effects clearly diminish at later stages, especially db/db which have obviously impaired autophagy. We found static magnetic fields directly promote actin assembly boost IF-induced Consequently, the pancreatic...
Hyperammonemia is frequently seen in tumor microenvironments as well liver diseases where it can lead to severe brain damage or death. Ammonia induces autophagy, a mechanism that cells may use protect themselves from external stresses. However, how sense ammonia has been unclear. Here we show culture medium alone containing Glutamine generate milimolar of at 37 degrees the absence cells. In addition, reveal acts through G protein-coupled receptor DRD3 (Dopamine D3) induce autophagy. At same...
Some dopamine receptor subtypes were reported to participate in autophagy regulation, but their exact functions and mechanisms are still unclear. Here we found that receptors D2 D3 (D2-like family) positive regulators of autophagy, while D1 D5 (D1-like negative regulators. Furthermore, ammonia, the two endogenous ligands receptors, both can induce internalization degradation. In addition, AKT (protein kinase B)-mTOR (mechanistic target rapamycin) AMPK (AMP-activated protein kinase) pathways...
Interactions between magnetic fields (MFs) and living cells may stimulate a large variety of cellular responses to MF, while the underlying intracellular mechanisms still remain great puzzle. On fundamental level, MF — cell interaction is affected by two broken symmetries: (a) left-right (LR) asymmetry (b) chirality DNA molecules carrying electric charges subjected Lorentz force when moving in MF. Here we report on chirality-driven effect static (SMFs) synthesis. This newly discovered...
// Zhiyuan Li 1 , Xinmiao Ji Dongmei Wang 1, 2 Juanjuan Liu Xin Zhang High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, Anhui, 230031, P. R. China University Science and Technology China, 230036, Correspondence to: Zhang, email: xinzhang@hmfl.ac.cn Keywords: mitosis, autophagy, autophagic flux, LC3, cell synchronization Received: February 26, 2016 Accepted: April 16, Published: May 18, ABSTRACT Mitosis is a fast process that involves dramatic cellular remodeling has high...
Mitochondrion is the major cellular energy producing organelle that at boundary between chemical reactions and physical processes. Although mitochondria have been shown to be affected by methods such as nonthermal plasma, whether static magnetic field (SMF) could also affect them still unclear. Here we used rat adrenal PC12 cells compare SMFs of different intensities for their effects on ATP (adenosine‐5′‐triphosphate), source produced mitochondria, which essential various Our results show...
// Juanjuan Liu 1, 2 , Xinmiao Ji 1 Zhiyuan Li Xingxing Yang Wenchao Wang Xin Zhang High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, Anhui, 230031, P. R. China University Science and Technology China, 230036, Correspondence to: Zhang, e-mail: xinzhang@hmfl.ac.cn Keywords: GNG7 (G protein γ subunit 7), autophagy, cell death, division, actin Received: January 13, 2016 Accepted: February 28, Published: April 02, 2016 ABSTRACT a...