Abstract The biological effects of high-gradient magnetic fields (HGMFs) have steadily gained the increased attention researchers from different disciplines, such as cell biology, therapy, targeted stem delivery and nanomedicine. We present a theoretical framework towards fundamental understanding HGMFs on intracellular processes, highlighting new directions for study living machinery: changing probability ion-channel on/off switching events by membrane magneto-mechanical stress, suppression...

Magnetic field switches the frequency bands of calcium waves, thereby changing/closing enzyme activity and metabolic pathways.

The interaction mechanisms between magnetic fields (MFs) and living systems, which remained hidden for more than a hundred years, continue to attract the attention of researchers from various disciplines: physics, biology, medicine, life sciences. Revealing these at cellular level would allow understand complex cell systems could help explain predict responses MFs, intervene in organisms' reactions MFs different strengths, directions, spatial distributions. We suggest several new physical MF...

Interactions between magnetic fields (MFs) and living cells may stimulate a large variety of cellular responses to MF, while the underlying intracellular mechanisms still remain great puzzle. On fundamental level, MF — cell interaction is affected by two broken symmetries: (a) left-right (LR) asymmetry (b) chirality DNA molecules carrying electric charges subjected Lorentz force when moving in MF. Here we report on chirality-driven effect static (SMFs) synthesis. This newly discovered...

Being essential for many pharmacodynamic and pharmacokinetic processes playing a crucial role in regulating substrate detachment that enables cellular locomotion, endocytotic mechanisms aspects still remain mystery therefore can hardly be controlled. Here, we report on experimental modeling studies of the magnetically assisted endocytosis functionalized superparamagnetic iron oxide nanoparticles by prostate cancer cells (PC-3) characterize time force scales uptake machinery. The results...

We show, combining simulations and analytical study, the evolution of magnetization distributions in ultrathin film with in-plane fields ${(H}_{\ensuremath{\parallel}})$ changes magnetic anisotropy characterized by quality factor, Q. Reconstruction their new types near Q or ${H}_{\ensuremath{\parallel}}$-induced reorientation phase transitions, from a domain structure (DS) perpendicular into state magnetization, are reported. Sinusoidal-like DS exist for ${H}_{\ensuremath{\parallel}}$ larger...

To explore cellular responses to high magnetic fields (HMF), we present a model of the interactions cells with homogeneous HMF that accounts for force exerted on paramagnetic/diamagnetic species. There are various chemical species inside living cell, many which may have large concentration gradients. Thus, when an is applied concentration-gradient forces act paramagnetic or diamagnetic and can either assist oppose particle movement through cytoplasm. We demonstrate possibilities changing...

We examine membrane pores and the channel stability of cells exposed to high-gradient magnetic fields (HGMFs). As an HGMF generates stress deformation in cell through gradient forces, stretch-activated voltage-gated ion channels are gated by both effective tension (σ) potential (U). By calculating a (σ, U)-phase diagram, we find unexpected region for subjected HGMF. Within this region, does not lose its integrity is stable against pore creation electric fields. Our theoretical arguments lead...

The diffusion of biologically active molecules is a ubiquitous process, controlling many mechanisms and the characteristic time scales for pivotal processes in living cells. Here, we show how high static magnetic field (MF) affects paramagnetic diamagnetic species including oxygen, hemoglobin, drugs. We derive solve equation describing such presence an MF as well reveal underlying mechanism MF's effect on diffusion. found that accelerates while slowing cell cytoplasm. When applied to oxygen...

A general framework for the domain size in any ultrathin film with perpendicular magnetic anisotropy is here discussed. The structure analyzed by using classical theory taking into consideration demagnetization field contribution to wall energy. sinusoidal model considered describe while approaching, two different cases, monodomain state in-plane magnetization. first case realized applying a large enough field. second one obtained decreasing anisotropy, which connected many systems increase...

We report on the nucleation of circular domains in outer shell magnetic, Co-rich, amorphous microwires over a wide range magnetic field pulse frequencies and amplitudes. Nucleation low barrier regime different numbers single was detected using magneto-optical Kerr effect. The amplitude frequency dependence domain probability is described framework model which agrees well with experimental data. have shown that to efficiently drive alternating electric current excitation, precise tuning necessary.

Cell-cycle progression is regulated by numerous intricate endogenous mechanisms, among which intracellular forces and protein motors are central players. Although it seems unlikely that possible to speed up this molecular machinery applying tiny external the cell, we show magnetic forcing of magnetosensitive bacteria reduces duration mitotic phase. In such bacteria, coupling cell cycle splitting chains biogenic nanoparticles (BMNs) provides a biological realization forcing. Using static...

The thickness-driven spin reorientation phase transition (RPT) in uniaxial semi-infinite ultrathin films and nanowires is studied both by micromagnetic simulations analytically. A significant influence of the sample edges on magnetization states was found near RPT from perpendicular to in-plane magnetization. It shown that when thickness exceeds thickness, effective anisotropy constant peaks at edge decays over characteristic distance L* edge. As a consequence, area width L*, an out-of-plane...