A5052868784- Magnetic properties of thin films
- Magnetic Properties and Applications
- Theoretical and Computational Physics
- Electromagnetic Fields and Biological Effects
- Magnetic and Electromagnetic Effects
- Physics of Superconductivity and Magnetism
- Spaceflight effects on biology
- Magnetic Properties of Alloys
- Magneto-Optical Properties and Applications
- Characterization and Applications of Magnetic Nanoparticles
- Plasma Applications and Diagnostics
- Cellular Mechanics and Interactions
- Magnetic and transport properties of perovskites and related materials
- Superconducting Materials and Applications
- Metallic Glasses and Amorphous Alloys
- Ion channel regulation and function
- Biofield Effects and Biophysics
- Planetary Science and Exploration
- Advanced MRI Techniques and Applications
- Microfluidic and Bio-sensing Technologies
- Nanoparticle-Based Drug Delivery
- Nerve injury and regeneration
- Cephalopods and Marine Biology
- Shape Memory Alloy Transformations
- Geomagnetism and Paleomagnetism Studies
Czech Academy of Sciences, Institute of Physics
2015-2025
Czech Academy of Sciences
2015-2025
Institute of Electrical Engineering
2023
High Magnetic Field Laboratory
2023
Chinese Academy of Sciences
2023
University of Białystok
2005-2018
Czech Academy of Sciences, Institute of Plasma Physics
2002-2015
Universidad Publica de Navarra
2009-2012
Czech Academy of Sciences, Institute of Atmospheric Physics
2012
Université Paris-Sud
2009
Abstract The biological effects of high-gradient magnetic fields (HGMFs) have steadily gained the increased attention researchers from different disciplines, such as cell biology, therapy, targeted stem delivery and nanomedicine. We present a theoretical framework towards fundamental understanding HGMFs on intracellular processes, highlighting new directions for study living machinery: changing probability ion-channel on/off switching events by membrane magneto-mechanical stress, suppression...
Abstract Non-thermal plasma (NTP) has nonspecific antibacterial effects, and can be applied as an effective tool for the treatment of chronic wounds other skin pathologies. In this study we analysed effect NTP on healing full-thickness acute wound model in rats. We utilised a single jet system generating atmospheric pressure air plasma, with ion volume density 5 · 10 17 m −3 gas temperature 30–35 °C. The were exposed to three daily treatments 1 or 2 minutes evaluated 3, 7 14 days after...
Spinal cord injury (SCI) is a condition that results in significant mortality and morbidity. Treatment of SCI utilizing stem cell transplantation represents promising therapy. However, current conventional treatments are limited by inefficient delivery strategies cells into the injured tissue. In this study, we designed magnetic system used it to accumulate labelled with superparamagnetic iron oxide nanoparticles (SPION) at specific site lesion. The loading engineered SPIONs guarantees...
F-actin (filamentous actin) has been shown to be sensitive mechanical stimuli and play critical roles in cell attachment, migration, cancer metastasis, but there are very limited ways perturb dynamics with low toxicity. Magnetic field is a noninvasive reversible physical tool that can easily penetrate cells human bodies. Here, we show 0.1/0.4-T 4.2-Hz moderate-intensity low-frequency rotating magnetic field-induced electric could directly decrease formation vitro vivo, which results...
Magnetic field switches the frequency bands of calcium waves, thereby changing/closing enzyme activity and metabolic pathways.
The transplantation of mesenchymal stem cells (MSC) is currently under study as a therapeutic approach for spinal cord injury, and the number transplanted that reach lesioned tissue one critical parameters. In this study, intrathecally labeled with superparamagnetic iron oxide nanoparticles were guided by magnetic field successfully targeted near lesion site in rat cord. Magnetic resonance imaging histological analysis revealed significant differences cell numbers distribution magnet...
Abstract Non-thermal plasma has been recognized as a promising tool across vast variety of biomedical applications, with the potential to create novel therapeutic methods. However, understanding molecular mechanisms behind non-thermal cellular effects remains significant challenge. In this study, we show how two types different plasmas induce cell death in mammalian cultures via formation multiple intracellular reactive oxygen/nitrogen species. Our results showed discrepancy superoxide...
Although 9.4 T magnetic resonance imaging (MRI) has been tested in healthy volunteers, its safety diabetic patients is unclear. Furthermore, the effects of high static fields (SMFs), especially gradient vs. uniform fields, have not investigated diabetics. Here, we consequences exposure to 1.0–9.4 SMFs different gradients (>10 T/m 0–10 T/m) on type 1 (T1D) and 2 (T2D) mice. We found that 14 h prolonged treatment (as as 55.5 (1.0–8.6 T) had negative T1D T2D mice, including spleen, hepatic,...
Non-thermal plasmas hold great promise for a variety of biomedical applications. To ensure safe clinical application plasma, rigorous analysis plasma-induced effects on cell functions is required. Yet mechanisms bacteria deactivation by non-thermal plasma remain largely unknown. We therefore analyzed the influence low-temperature atmospheric Gram-positive and Gram-negative bacteria. Using scanning electron microscopy, we demonstrate that both strains in minute were completely destroyed...
Studies have shown that 9.4 Tesla (9.4 T) high-field magnetic resonance imaging (MRI) has obvious advantages in improving image resolution and capacity, but their safety issues need to be further validated before clinical approval. Meanwhile, emerging experimental evidences show moderate high intensity Static Magnetic Fields (SMFs) some anti-cancer effects. We examined the effects of two opposite SMF directions on lung cancer bearing mice found when cell-bearing were treated with T SMFs for...
The interaction mechanisms between magnetic fields (MFs) and living systems, which remained hidden for more than a hundred years, continue to attract the attention of researchers from various disciplines: physics, biology, medicine, life sciences. Revealing these at cellular level would allow understand complex cell systems could help explain predict responses MFs, intervene in organisms' reactions MFs different strengths, directions, spatial distributions. We suggest several new physical MF...
Interactions between a micro-magnet array and living cells may guide the establishment of cell networks due to cellular response magnetic field. To manipulate mesenchymal stem free nanoparticles by high field gradient, we used quality micro-patterned NdFeB films around which stray field's value direction drastically change across body. Such arrays coated with parylene produce gradients that affect in two main ways: i) causing migration adherence covered surface ii) elongating directions...
A rigorous biochemical analysis of interactions between non-thermal plasmas (NTPs) and living cells has become an important research topic, due to recent developments in biomedical applications plasmas. Here, we decouple distinct cell death pathways targeted by chemically different NTPs. We show that helium NTP treatment, results necrosome formation necroptosis execution, whereas air leads mTOR activation autophagy inhibition, induces mTOR-related necrosis. On the contrary, ozone (abundant...
Interactions between magnetic fields (MFs) and living cells may stimulate a large variety of cellular responses to MF, while the underlying intracellular mechanisms still remain great puzzle. On fundamental level, MF — cell interaction is affected by two broken symmetries: (a) left-right (LR) asymmetry (b) chirality DNA molecules carrying electric charges subjected Lorentz force when moving in MF. Here we report on chirality-driven effect static (SMFs) synthesis. This newly discovered...
Being essential for many pharmacodynamic and pharmacokinetic processes playing a crucial role in regulating substrate detachment that enables cellular locomotion, endocytotic mechanisms aspects still remain mystery therefore can hardly be controlled. Here, we report on experimental modeling studies of the magnetically assisted endocytosis functionalized superparamagnetic iron oxide nanoparticles by prostate cancer cells (PC-3) characterize time force scales uptake machinery. The results...
Nowadays, the focus in medicine on molecular genetics has resulted a disregard for physical basis of treatment even though many diseases originate from changes cellular mechanics. Perturbations nanomechanics promote pathologies, including cardiovascular disease and cancer. Furthermore, whilst biological therapeutic effects magnetic fields are well-established fact, to date underlying mechanisms remain obscure. Here, we show that oscillating high-gradient field (HGMF) mechanical vibration...
Background Ultra‐high field magnetic resonance imaging (MRI) has obvious advantages in acquiring high‐resolution images. 7 T MRI been clinically approved and 21.1 also tested on rodents. Purpose To examine the effects of ultra‐high mice behavior neuron activity. Study Type Prospective, animal model. Animal Model Ninety‐eight healthy C57BL/6 18 depression model mice. Field Strength 11.1–33.0 SMF (static field) for 1 hour 8 hours. Gradients were not no sequence was used. Assessment Open test,...
A specially developed setup for precise measurement of magnetic hysteresis and Barkhausen noise is presented in this paper. novelty the consists a unique combination two main features: an accurate local determination field improved feedback control magnetization process. First, measured by Hall sensors at different distances above sample. The sample determined linear extrapolation these profiles tangential fields to surface. Second, digital loop ac process proposed. algorithm combines...