O. Churpita

ORCID: 0000-0001-7156-9024
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About
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Research Areas
  • Plasma Applications and Diagnostics
  • Plasma Diagnostics and Applications
  • Heme Oxygenase-1 and Carbon Monoxide
  • Laser-induced spectroscopy and plasma
  • Burn Injury Management and Outcomes
  • Metal and Thin Film Mechanics
  • Gas Sensing Nanomaterials and Sensors
  • ZnO doping and properties
  • Electrospun Nanofibers in Biomedical Applications
  • Transition Metal Oxide Nanomaterials
  • Ga2O3 and related materials
  • Nanoplatforms for cancer theranostics
  • Quantum Dots Synthesis And Properties
  • Erythrocyte Function and Pathophysiology
  • Semiconductor materials and devices
  • Dust and Plasma Wave Phenomena
  • Advanced Surface Polishing Techniques
  • Surface Roughness and Optical Measurements
  • TiO2 Photocatalysis and Solar Cells
  • Catalytic Processes in Materials Science
  • Wound Healing and Treatments
  • Spaceflight effects on biology
  • Copper-based nanomaterials and applications
  • Electrohydrodynamics and Fluid Dynamics
  • Cellular Mechanics and Interactions

Czech Academy of Sciences, Institute of Physics
2008-2019

Czech Academy of Sciences
2006-2018

Abstract Non-thermal plasma (NTP) has nonspecific antibacterial effects, and can be applied as an effective tool for the treatment of chronic wounds other skin pathologies. In this study we analysed effect NTP on healing full-thickness acute wound model in rats. We utilised a single jet system generating atmospheric pressure air plasma, with ion volume density 5 · 10 17 m −3 gas temperature 30–35 °C. The were exposed to three daily treatments 1 or 2 minutes evaluated 3, 7 14 days after...

10.1038/srep45183 article EN cc-by Scientific Reports 2017-03-24

Abstract Non-thermal plasma has been recognized as a promising tool across vast variety of biomedical applications, with the potential to create novel therapeutic methods. However, understanding molecular mechanisms behind non-thermal cellular effects remains significant challenge. In this study, we show how two types different plasmas induce cell death in mammalian cultures via formation multiple intracellular reactive oxygen/nitrogen species. Our results showed discrepancy superoxide...

10.1038/srep07129 article EN cc-by Scientific Reports 2014-11-20

Non-thermal plasmas hold great promise for a variety of biomedical applications. To ensure safe clinical application plasma, rigorous analysis plasma-induced effects on cell functions is required. Yet mechanisms bacteria deactivation by non-thermal plasma remain largely unknown. We therefore analyzed the influence low-temperature atmospheric Gram-positive and Gram-negative bacteria. Using scanning electron microscopy, we demonstrate that both strains in minute were completely destroyed...

10.1063/1.4907624 article EN Applied Physics Letters 2015-02-02

A rigorous biochemical analysis of interactions between non-thermal plasmas (NTPs) and living cells has become an important research topic, due to recent developments in biomedical applications plasmas. Here, we decouple distinct cell death pathways targeted by chemically different NTPs. We show that helium NTP treatment, results necrosome formation necroptosis execution, whereas air leads mTOR activation autophagy inhibition, induces mTOR-related necrosis. On the contrary, ozone (abundant...

10.1038/s41598-017-00689-5 article EN cc-by Scientific Reports 2017-03-29

Background/Aims: Alteration of cancer cell redox status has been recognized as a promising therapeutic implication.In recent years, the emerged field non-thermal plasma (NTP) shown considerable promise in various biomedical applications, including therapy.However, understanding molecular mechanisms procuring cellular responses remains incomplete.Thus, aim this study was rigorous biochemical analysis interactions between NTP and liver cells.Methods: The concept validated using three different...

10.33594/000000009 article EN cc-by-nc-nd Cellular Physiology and Biochemistry 2019-02-18

Nowadays, the focus in medicine on molecular genetics has resulted a disregard for physical basis of treatment even though many diseases originate from changes cellular mechanics. Perturbations nanomechanics promote pathologies, including cardiovascular disease and cancer. Furthermore, whilst biological therapeutic effects magnetic fields are well-established fact, to date underlying mechanisms remain obscure. Here, we show that oscillating high-gradient field (HGMF) mechanical vibration...

10.1063/1.4895459 article EN Applied Physics Letters 2014-09-08

Eighty years have passed since Langmuir's first use of the word 'plasma' for describing ionized media. On this occasion we would like to present selected recent results on application Langmuir probes diagnose plasma jet systems. To demonstrate versatility probe method give examples measurements spatial distribution parameters as well their temporal dependence in cases when system operates a pulsed regime. A part paper is devoted introducing technique, especially with regard its under...

10.1088/0963-0252/18/1/014009 article EN Plasma Sources Science and Technology 2008-11-14

Non-thermal plasma research has put a growing focus on the bacteria inactivation problem. Here we show how non-thermal destroys Gram-positive and Gram-negative discuss mechanisms of bactericidal effects.

10.1039/c6ra02368a article EN RSC Advances 2016-01-01

We report on optical-absorption study of ${\text{Zn}}_{1\ensuremath{-}x}{\text{Mn}}_{x}\text{O}$ $(x=0--0.06)$ films fused silica substrates taking special attention to the spectral range fundamental absorption edge (3.1--4 eV). Well-pronounced excitonic lines observed in region 3.40--3.45 eV were found shift higher energies with increasing Mn concentration. The optical band-gap energy increases $x$ too, reliably evidencing strong coupling between oxygen holes and localized spins manganese...

10.1103/physrevb.81.153104 article EN Physical Review B 2010-04-30

We describe new multijet low-temperature plasma discharge systems designed for a variety of biomedical applications. These are capable providing stable jet channels between the nozzles and either biomaterial or metallic dielectric surfaces at atmospheric pressure. The proposed direct electrode arrays allow reaching rather extensive areas treatments.

10.1615/plasmamed.2011003215 article EN Plasma Medicine 2011-01-01

Abstract Low‐pressure plasma jet system with two hollow cathodes was used for deposition of Ba x Sr 1– TiO 3 (BSTO) ferroelectric thin films. Two RF cathode guns were pointed to the substrate where BSTO films deposited. High density discharge generated in ceramic nozzles made SrTiO (STO) and BaTiO (BTO). Pulse modulated power applied on water‐cooled copper block insulated from by grounded stainless steel shield. In experiment, composition controlled magnitude average particular STO BTO...

10.1002/ctpp.200810083 article EN Contributions to Plasma Physics 2008-06-23
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