A5073710429- Oral microbiology and periodontitis research
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Rheumatoid Arthritis Research and Therapies
- Bone and Dental Protein Studies
- Autoimmune and Inflammatory Disorders
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Sarcoidosis and Beryllium Toxicity Research
- Ferroptosis and cancer prognosis
- Organ Transplantation Techniques and Outcomes
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Liver physiology and pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Salivary Gland Disorders and Functions
- Sirtuins and Resveratrol in Medicine
- Mycorrhizal Fungi and Plant Interactions
- Cervical and Thoracic Myelopathy
- Heme Oxygenase-1 and Carbon Monoxide
- Peptidase Inhibition and Analysis
- Medicinal Plants and Bioactive Compounds
Harbin Medical University
2016-2025
Second Affiliated Hospital of Harbin Medical University
2016-2025
Tianjin First Center Hospital
2021
Tianjin Medical University
2021
Peking University
2020
Hydrogels are widely used as wound dressings for healing, but when hydrogels absorb exudate, swelling occurs and compresses the surrounding tissue, affecting healing. A chitosan injectable (CS/4-PA/CAT) hydrogel based on catechol 4-glutenoic acid was prepared to avoid promote After cross-linking by UV light, pentenyl groups formed hydrophobic alkyl chains which give a network thus control its swelling. CS/4-PA/CAT retained their non-swelling long time in PBS solution at 37 °C. had good...
Background: Acute lung injury (ALI) is a leading cause of mortality in patients with sepsis due to proinflammatory endothelial changes and permeability defects. Mitochondrial dysfunction recognized as critical mediator the pathogenesis sepsis-induced ALI. Although mitophagy regulation mitochondrial quality well recognized, little known about its role ECs during Sirtuin 1 (SIRT1) histone protein deacetylase involved inflammation, mitophagy, cellular senescence. Here, authors show type late...
Human dental pulp stem cells (hDPSCs) possess self‑renewal and osteogenic differentiation properties, have been used for orofacial bone regeneration periodontal treatment. Aspirin has demonstrated to enhance the of marrow mesenchymal (MSCs); however, impact aspirin on hDPSCs remains unknown. In present study, were characterized by flow cytometry, while their clonogenic potential multipotency assessed using alizarin red, Oil red O alcian blue staining. The effect hDPSC viability was Cell...
Background: Both genetic and environmental factors contribute to the development of periodontitis. Genetic studies identified a variety candidate genes for The aim present study is identify most promising periodontitis using an integrative gene ranking method. Methods: Seed that were confirmed be associated with text mining. Three types then extracted from different resources (expression profiles, genome‐wide association studies). Combining seed genes, four freely available bioinformatics...
Bisphosphonates (BPs) are some of the most widely used drugs in osteoporosis (OP) treatment, but they can cause severe side effects such as bisphosphonate-related osteonecrosis jaw (BRONJ), causing great pain patients. It is necessary to develop a novel drug for treating OP with fewer effects. In this study, carbon dots, ALEN-CDs, derived from polyethylene glycol (PEG) and alendronate (ALEN) developed. ALEN-CDs have good biocompatibility, photoluminescence (PL) properties, bone-targeting...
Oral squamous cell carcinoma (OSCC), one of the 10 most common types neoplasms in US, constitutes ~90% all cases oral malignancies. Chemoresistance and metastasis are difficult to avoid during course treatment, leading a poor prognosis high mortality rate for patients with OSCC. Autophagy, critical conserved cellular process, has been reported be highly associated regulation chemoresistance cancer cells. The present study investigated role karyopherin α2 (KPNA2), member importin α family,...
Abstract Background: The family with sequence similarity 20-member C (Fam20C) kinase plays important roles in physiopathological process and is responsible for majority of the secreted phosphoproteome, including substrates associated tumor cell migration. However, it remains unclear whether Fam20C a role cancers. Here, we aimed to analyze expression prognostic value pan-cancer gain insights into association between immune infiltration. Methods: We analyzed patterns associations levels...
Background Cell survival or death is one of the key scientific issues inflammatory response. To regulate cell during occurrence and development periodontitis, various forms programmed death, such as pyroptosis, ferroptosis, necroptosis, apoptosis, have been proposed. It has found that ferroptosis characterized by iron-dependent lipid peroxidation involved in cancer, degenerative brain diseases diseases. Furthermore, NCOA4 considered ferroptosis-related genes (FRGs) contributing to...
Hypoxia regulates a number of cell biological processes, including survival, development and differentiation. Deferoxamine (DFO), an oral chelator for blood transfusion patients, has been demonstrated to induce hypoxia is frequently used as hypoxia‑mimicking agent. The purpose the present study was investigate influence DFO on proliferation, migration osteogenic differentiation human periodontal ligament cells (hPDLCs). effects hPDLC viability were measured using MTT wound healing assay. To...
Abstract Background Tongue squamous cell carcinoma (TSCC) is the most common oral cavity cancer, and p16 immunohistochemistry an exact available tool in prognostic predictive characterization of cancers head neck. Microorganisms have a close relationship with development TSCC. However, association between bacteria status has not been well defined case Compared traditional clinical microbial collection methods, formalin-fixed paraffin-embedded (FFPE) tissue samples several advantages. Methods...
Cirrhosis is the terminal stage of hepatic diseases and prone to develop into hepatocyte carcinoma. Increasing evidence suggests that transplantation dental pulp stem cells (DPSCs) may promote recovery from cirrhosis, but key regulatory mechanisms involved remain be determined. In this study, we overexpressed human growth factor (hHGF) in primary rat DPSCs evaluated effects HGF overexpression on biological behaviors therapeutic efficacy grafted cirrhosis. Liver cirrhosis was induced via...
Background: Lung ischemia-reperfusion injury (LIRI) remains the major cause of primary lung dysfunction after transplantation. Diabetes mellitus (DM) is an independent risk factor for morbidity and mortality following Mitochondrial recognized as a key mediator in pathogenesis diabetic LIRI. Melatonin has been reported to be safe potent preserving mitochondrial function agent. This study aimed at investigating potential therapeutic effect mechanisms melatonin on Methods: High-fat-diet-fed...
Family with sequence similarity 20‑member C (FAM20C), a recently characterized Golgi kinase, performs numerous biological functions by phosphorylating more than 100 secreted proteins. However, the role of FAM20C in salivary glands remains undefined. The present study demonstrated that is mainly located cytoplasm duct epithelial cells glands. Fam20cf/f; Mmtv‑Cre mice were created which Fam20c was inactivated gland and observed number ducts ductal cross‑sectional area increased significantly,...
Abstract Background The family with sequence similarity 20-member C (FAM20C) kinase, a Golgi casein which is responsible for phosphorylating the majority of extracellular phosphoproteins within S-x-E/pS motifs, and fundamentally associated multiple biological processes to maintain cell proliferation, biomineralization, migration, adhesion, phosphate homeostasis. In dissecting how FAM20C regulates downstream molecules potential mechanisms, however, there are target FAM20C, particularly many...
Crumb rubber (CR) is a commonly used infill material in artificial turf worldwide. However, the potential health risk associated with exposure to CR containing environmentally persistent free radicals (EPFRs) remains under investigation. Herein, we observed widespread presence of particles range 2.8-51.4 μg/m3 and EPFRs exceeding 6 × 1015 spins/g ambient air surrounding fields. Notably, abundance these tended increase number operating years playing Furthermore, by analyzing saliva samples...
Oral tongue squamous cell carcinoma (OTSCC) is an aggressive cancer which has high mortality rates. HOXA transcript at the distal tip (HOTTIP) a lncRNA that can be used as prognostic marker in multiple carcinomas. The expression of HOTTIP found to elevated OTSCC tissues, and such elevation correlated with poor prognosis. However, its functional role regulating growth metastasis cells remains elusive requires further investigation.HOTTIP-silenced were established by inhibiting via exclusive...
Introduction Aspirin is a common antipyretic, analgesic, and anti-inflammatory drug, which has been reported to extend life in animal models application the treatment of aging-related diseases. However, it remains unclear about effects aspirin on bone marrow-derived mesenchymal stromal cells (BM-MSCs). Here, we aimed analyze influence senescence young BM-MSCs. Methods BM-MSCs were serially passaged construct replicative model. SA-β-gal staining, PCR, western blot, RNA-sequencing performed...
After Peripheral nerve injuries (PNI), many complicated pathophysiologic processes will happen. A global view of functional changes following PNI is essential for the looking adequate therapeutic approaches. In this study, we performed an in-depth analysis on temporal expression profiles after sciatic injury by bioinformatic methods, including (1) cluster samples; (2) identification gene co-expression modules(CEMs) correlated with time points; (3) differentially expressed genes at each point...
Neurogenic heterotopic ossification is a disorder of aberrant bone formation affecting one in five patients sustaining spinal cord injury or traumatic brain (SCI-TBI-HO). However, the underlying mechanisms SCI-TBI-HO have proven difficult to elucidate. The aim present study identify most promising candidate genes and biological pathways for SCI-TBI-HO. In this study, we used text mining generate potential explanations Moreover, employed several additional datasets, including gene expression...
Family with sequence similarity 20 member C (FAM20C) is a Golgi casein kinase that phosphorylates extracellularly-secreted regulatory proteins involved in bone development and mineralization, but its specific role still largely unknown. In this study, to examine the mechanisms FAM20C influences development, we cross-bred Osx-Cre