A5027488744- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Electrospun Nanofibers in Biomedical Applications
- Hip and Femur Fractures
- Bone fractures and treatments
- Orthopedic Surgery and Rehabilitation
- Spinal Cord Injury Research
- Wound Healing and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Mesenchymal stem cell research
- Pelvic and Acetabular Injuries
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroscience and Neural Engineering
- Elbow and Forearm Trauma Treatment
- Spinal Fractures and Fixation Techniques
- Injury Epidemiology and Prevention
- Graphene and Nanomaterials Applications
- Peripheral Nerve Disorders
- Trauma and Emergency Care Studies
- Tendon Structure and Treatment
- Bone and Joint Diseases
- Emergency and Acute Care Studies
- Tissue Engineering and Regenerative Medicine
Peking University
2015-2024
Peking University People's Hospital
2015-2024
King University
2019-2023
Xi'an Peihua University
2015-2022
University of Strathclyde
1992-1996
Changchun Institute of Applied Chemistry
1985-1990
Academia Sinica
1985
Abstract The most severe sequelae after rehabilitation from SARS are femoral head necrosis and pulmonary fibrosis. We performed a 15-year follow-up on the lung bone conditions of patients. evaluated recovery damage in an observational cohort study patients using CT scans, hip joint MRI examinations, function tests questionnaires. Eighty medical staff contracted 2003. Two died SARS, 78 were enrolled this August 2003 to March 2018. Seventy-one completed follow-up. percentage lesions scans...
Autologous nerve transplantation, which is the gold standard for clinical treatment of peripheral injury, still has many limitations.In this study, aligned chitosan fiber hydrogel (ACG) grafted with a bioactive peptide mixture consisting RGI (Ac-RGIDKRHWNSQGG) and KLT (Ac-KLTWQELYQLKYKGIGG), designated as ACG-RGI/KLT, was used conduit filler to repair sciatic defects in rats.Methods: Chitosan nanofiber prepared by combination electrospinning mechanical stretching methods, then KLT, are...
Abstract Currently, diabetic infectious wound treatments remain a significant challenge for regenerative medicine due to the unicity of clinical dressings, which lack systemic multifunctional dressings with high absorbability, customizable shape, rapid self‐healing, guiding tissue regeneration, and restoring physiological functions. Here, DNA hydrogel is conveniently obtained through grafting units polyethyleneimine dynamic cross‐linking doped heating function black phosphorus quantum dots....
Abstract There are issues and challenges in treating deep burns because of the long recovery time, frequent dressing changes, wound infection, easy to form scar that influence aesthetics. Besides, some specific tissues not suitable for large coverage (e.g., face, perineum). Therefore, an ideal burn should have good adhesion properties fit effectively, painless quick replacement, resistant accelerate healing, reduce scarring facilitate monitoring diagnosis. Herein, anti‐dehydration...
At present, repair methods for peripheral nerve injury often fail to get satisfactory result. Although various strategies have been adopted investigate the microenvironment after injury, underlying molecular mechanisms of neurite outgrowth remain unclear. In this study, we evaluate effects exosomes from gingival mesenchymal stem cells (GMSCs) combined with biodegradable chitin conduits on regeneration. GMSCs were isolated human tissue and characterized by surface antigen analysis in vitro...
Nerve guidance conduits with hollow lumen fail to regenerate critical-sized peripheral nerve defects (15 mm in rats and 25 humans), which can be improved by a beneficial intraluminal microenvironment. However, individual cues provided filling materials are inadequate eliminate the functional gap between regenerated nerves normal nerves. Herein, an aligned fibrin/functionalized self-assembling peptide (AFG/fSAP) interpenetrating nanofiber hydrogel that exerting synergistic topographical...
Abstract A grade 3 burn is a nonstatic fatal injury, which can lead to complete damage the skin structure, accompanied by series of symptoms such as persistent inflammation, pain, pruritus, ulcer, and peripheral neuropathy. Although primary clinical treatment grafting, it cannot comprehensively solve symptoms. Here, multifunctional DNA hydrogel integrated system conveniently obtained through dynamic cross‐linking unit, polyacrylamide, l ‐ascorbate 2‐phosphate ( ‐A2P) formation dense hydrogen...
Abstract Trauma often results in peripheral nerve injuries (PNIs). These are particularly challenging therapeutically because of variable diameters, slow axonal regeneration, infection severed ends, fragility the tissue, and intricacy surgical intervention. Surgical suturing is likely to cause additional damage nerves. Therefore, an ideal scaffold should possess good biocompatibility, diameter adaptability, a stable biological interface for seamless biointegration with tissues. Inspired by...
Abstract Hydrogel adhesion materials are widely reported for tissue engineering repair applications, however, wet surface moisture can reduce the wet‐adhesion properties and mechanical strength of hydrogels limiting their application. Here, anti‐hydration gelatin–acrylic acid–ethylene dimethacrylate (GAE) with hydrophobic cross‐linked chains constructed. The prepared GAE hydrogel is soaked in PBS (3 days) a volume change 0.6 times original adhesive strength, Young's modulus, toughness, burst...
Graphene oxide is currently used in peripheral nerve engineering but has certain limitations, such as cytotoxicity and lack of electrical conductivity, both which are crucial regulating nerve-associated cell behaviors.
Injectable and biodegradable DNA gel nanoparticles with a controllable charge size as photothermal therapeutic agent improve the permeability of drugs, reduce drug resistance, survival rate mice.
Abstract Carbon nanotubes (CNTs) have attracted increasing attention in the field of peripheral nerve tissue engineering due to their unique structural and physical characteristics. In this study, a novel type aligned conductive scaffolds composed polycaprolactone (PCL) CNTs were fabricated via electrospinning. Utilizing mussel-inspired polydopamine (PDA) surface modification, brain-derived neurotrophic factor (BDNF) was loaded onto PCL/CNT fibrous obtain PCL/CNT-PDA-BDNF capable sustained...
Bioactive macromolecular drugs known as Growth Factors (GFs), approved by the Food and Drug Administration (FDA), have found successful application in clinical practice. They hold significant promise for addressing peripheral nerve injuries (PNIs). Peripheral guidance conduits (NGCs) loaded with GFs, context of tissue engineering, can ensure sustained efficient release these bioactive compounds. This, turn, maintains a stable, long-term, effective GF concentration essential treating damaged...
To evaluate the effect of calcar screw use in proximal humeral fractures with unstable medial support treated locked plates.Standard osteotomies were performed 36 cadaveric humeri to create a surgical neck fracture model. For static testing, 12 pairs divided into 4 groups: normal alignment and varus deformity groups without 5-mm deficiencies. Calcar function was measured each group by axial, shear, torsion stiffness tests. Another 6 deficiencies subjected cyclic loading tests model...
Articular cartilage defects are difficult to treat, but drug-loaded tissue engineering scaffolds provide a possible treatment option for these types of injuries.
Peripheral nerve injury (PNI) usually leads to progressive muscle atrophy and poor functional recovery. Previous studies have demonstrated that non-coding ribonucleic acid (ncRNA) is a key regulator of beneficial for the treatment PNI. We aimed analyze whole transcriptome involved in denervated after Animal models sciatic were assessed at 0 (control group), 1, 2, 4, 8 weeks injury. The expression patterns gastrocnemius profiled using RNA sequencing each time point compared obtained control...
Motor endplates (MEPs) are the important interfaces between peripheral nerves and muscle fibers. Investigation of spatial distribution MEPs could help us better understand neuromuscular functional activities improve diagnosis therapy related diseases. Methods: Fluorescent α-bungarotoxin was injected to label motor in whole-mount skeletal muscles, tissue optical clearing combined with light-sheet microscopy used investigate in-muscle nerve branches different muscles wild-type transgenic...
Peripheral nerve injury has troubled clinical doctors for many years. To obtain better function recovery of peripheral repair at the base hollow guidance conduit (NGC), NGCs with fillers were developed in application tissue-engineered graft. In this study, expanded 3D nanofibre sponge scaffolds orientation and porosity first fabricated by electrospinning gas-foaming technique. Polylactic acid (PLA)/silk fibroin prepared as filler to construct sponges containing NGC (SNGC). SNGC could promote...