A5101588555- Antimicrobial Resistance in Staphylococcus
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Photodynamic Therapy Research Studies
- Pancreatic and Hepatic Oncology Research
- Streptococcal Infections and Treatments
- Curcumin's Biomedical Applications
- Infections and bacterial resistance
- Plant Pathogenic Bacteria Studies
- Nanoplatforms for cancer theranostics
- Antimicrobial Peptides and Activities
- Signaling Pathways in Disease
- Diet and metabolism studies
- Inflammasome and immune disorders
- Acupuncture Treatment Research Studies
- Photoacoustic and Ultrasonic Imaging
- Milk Quality and Mastitis in Dairy Cows
- Genital Health and Disease
- Biochemical Analysis and Sensing Techniques
- Bacterial biofilms and quorum sensing
- Bioactive natural compounds
- Mitochondrial Function and Pathology
- Neurological Disease Mechanisms and Treatments
- Sexual function and dysfunction studies
- Probiotics and Fermented Foods
Nanjing University
2024-2025
Nanjing General Hospital of Nanjing Military Command
2024-2025
Changchun University of Chinese Medicine
2022-2025
Second Affiliated Hospital of Harbin Medical University
2025
Harbin Medical University
2025
First Affiliated Hospital of Xi'an Jiaotong University
2016-2023
Dalian Medical University
2023
Second Affiliated Hospital of Dalian Medical University
2023
Union Hospital
2022
Huazhong University of Science and Technology
2022
Abstract Diabetes-associated cognitive impairment (DACI) can increase the risk of major cardiovascular events and death. Neuronal functionality is highly dependent on mitochondria emerging evidence has shown that mitochondrial transplantation a potential effective strategy reduce brain injury associated disorders. Platelets are abundant in blood be considered readily available source small-size mitochondria. These cells easily acquired from peripheral with minimal invasion via simple...
Abstract Dementia, as an advanced diabetes-associated cognitive dysfunction (DACD), has become the second leading cause of death among diabetes patients. Given that little guidance is currently available to address DACD process, it imperative understand underlying mechanisms and screen out specific therapeutic targets. The excessive endogenous fructose produced under high glucose conditions can lead metabolic syndrome peripheral organ damage. Although generated by brain, role in exacerbation...
Cervical cancer is a malignant disease and threat to women's health worldwide. Surgical resection followed by radiotherapy or chemotherapy the main treatment strategy for cervical cancer; however, patients with cancer, especially those late-stage disease, may not benefit from these traditional therapies, which results in poor clinical outcome. ALOX12B gene encoding lipoxygenase, mutation was detected lung breast cancer. Furthermore, essential proliferation of epidermoid carcinoma cells; role...
Treatment for non‑small cell lung cancer (NSCLC) remains challenging due to frequent recurrence and the development of resistance platinum‑based chemotherapy. The mechanism underlying NSCLC chemoresistance unclear. present study aimed investigate cisplatin in cells it found that expression Bcl‑2‑associated transcription factor 1 (BCLAF1) was higher A549 line with (A549/DDP) by western blotting reverse‑transcription quantitative PCR, suggesting elevated BCLAF1 is associated acquired cells....
Integrative and conjugative elements (ICEs) play a vital role in bacterial evolution by carrying essential genes that confer adaptive functions to the host. Despite their importance, mechanism underlying stable inheritance of ICEs, which is necessary for acquisition new traits bacteria, remains poorly understood. Here, we identified SezAT, type II toxin-antitoxin (TA) system, AbiE, IV TA system encoded within ICE Ssu HN105, coordinately promote stabilization mediate multidrug resistance...
Circular RNAs (circRNAs) play a vital role in diabetic peripheral neuropathy. However, their expression and function Schwann cells individuals with neuropathy remain poorly understood. Here, we performed protein profiling circRNA sequencing of sural nerves patients controls. Protein revealed 265 differentially expressed proteins the group. Gene Ontology indicated that were mainly enriched myelination mitochondrial oxidative phosphorylation. A real-time polymerase chain reaction assay to...
The loss of function mutation AT‑rich interactive domain 1A (ARID1A) often occurs in patients with breast cancer. It has been found that ARID1A knockout can enhance both the migratory activity renal carcinoma cells and their sensitivity to therapeutic drugs by promoting epithelial-mesenchymal transition (EMT); however, its mechanisms action cancer remain unclear. In present study, immunohistochemistry reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) revealed expression...
Hepatocyte growth factor (HGF) is a potential therapeutic agent for diabetic nephropathy. The mechanisms the renoprotective effect of HGF have been studied extensively, but antioxidant signalling in nephropathy minimally understood. Our observations indicated that nitrated guanine nucleotide, 8-nitroguanosine 3'5'-cyclic monophosphate (8-nitro-cGMP) diminished high glucose (HG)-treated rat mesangial cells (RMC). However, obviously lifted intracellular 8-nitro-cGMP level, which was...
KIFs have been reported to play a critical role in variety of tumors, and KIF20B is protein KFIs. In this research, was highly expressed the GEO database our hospital’s data, high expression suggested poor prognosis. We detect pancreatic cancer adjacent normal tissues using immunohistochemistry. Knockdown cell lines, PANC-1 BxPC-3 cells, inhibited proliferation which are detected by colony formation assays, CCK8, western bolt Ki-67 PCNA. Xenograft assay showed similar result vivo. potential...
Studies have found that gut microbiota may be associated with the development of erectile dysfunction (ED); however, exact link between two remains unclear. This study aimed to elucidate relationship and risk ED from a genetic perspective. We investigated microflora using two-sample Mendelian randomization. GWAS-pooled data for were obtained 223805 participants in Europe. GWAS summary subjects Europe 18340 24 cohorts. used inverse-variance weighted (IVW) estimator as primary method...
Background. Pancreatic cancer is a malignant tumor of the digestive tract, which difficult to diagnose and treat due bad early diagnosis. We aimed explore role kinesin superfamily 4A (KIF4A) in pancreatic ductal adenocarcinoma (PDAC). Methods. first used bioinformatic website screen data TCGA, KIF4A protein was detected among 86 specimens patients our hospital combined with clinic-pathological characteristics survival analysis. loss-expression cell lines were established by RNA interference...
Objective To evaluate the effect of electroacupuncture(EA)pretreatment on NOD-like receptor pyrin domain-containing 3(NLRP3)in neurons during cerebral ischemia-reperfusion(I/R)in rats. Methods Fifty-four adult male Sprage-Dawley rats, aged 7 weeks, weighing 250-280 g, were randomly divided into 3 groups(n=18 each )using a random number table: sham operation group(group S), group I/R, and EA pretreatment E). Cerebral I/R was induced by occlusion right middle artery for 90 min using...