A5009110720- Glycosylation and Glycoproteins Research
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Carbohydrate Chemistry and Synthesis
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects of Natural Compounds
- Insect Resistance and Genetics
- RNA modifications and cancer
- Genetically Modified Organisms Research
- 14-3-3 protein interactions
- Plant Taxonomy and Phylogenetics
- Seedling growth and survival studies
- Nanoplatforms for cancer theranostics
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Histiocytic Disorders and Treatments
- Antimicrobial Resistance in Staphylococcus
- Diabetes Treatment and Management
- FOXO transcription factor regulation
- Plant tissue culture and regeneration
- Plant and animal studies
- Hemoglobinopathies and Related Disorders
Changchun University of Chinese Medicine
2025
First Affiliated Hospital Zhejiang University
2020-2025
Brigham and Women's Hospital
2024
Blood Center of Zhejiang Province
2020-2024
Zhejiang University
2020-2024
National Health and Family Planning Commission
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2023
Plant Industry
2000
Commonwealth Scientific and Industrial Research Organisation
1998-2000
Liver cancer is a malignancy with high morbidity and mortality rates. Serpin family E member 2 (SERPINE2) has been reported to play key role in the metastasis of many tumors. In this study, we aimed investigate potential mechanism SERPINE2 liver metastasis.
Abstract Liver cancer is characterized by aggressive growth and high mortality. Asialoglycoprotein receptor 1 (ASGR1), which expressed almost exclusively in liver cells, reduced cancer. However, the specific mechanism of ASGR1 function has not been fully elucidated. On basis database screening, we identified as a tumor suppressor regulated DNA methylation. Expression was downregulated correlated with size, grade, survival. Functional gain loss experiments showed that suppresses progression...
Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide, and its specific mechanism has not been fully elucidated. Inactivation tumor suppressors may contribute to occurrence, progression, recurrence HCC. DNA methylation a crucial involved in regulating occurrence Herein, we aimed identify key methylation-related as well potential biomarkers therapeutic targets Methods: Combined analysis TCGA GEO databases was performed obtain Methyl-target sequencing analyze level GNA14...
Pancreatic ductal adenocarcinoma (PDAC), one of the worst prognosis types tumors, is characterized by dense extracellular matrix, which compresses tumor vessels and forms a physical barrier to inhibit therapeutic drug penetration efficacy. Herein, losartan, an antihypertension agent, applied as stroma modulator developed into nanosystem. A series lipophilic losartan prodrugs are constructed esterification hydroxyl group on fatty acids. Based self-assembly ability hydrodynamic diameter,...
Abstract The farnesoid X receptor (FXR), as a bile acid (BA) sensor, plays an important role in the regulation of lipid metabolism. However, effects and underlying molecular mechanisms FXR on intestinal glucose homeostasis remain elusive. Herein, we demonstrated that transporter 2 (GLUT2) are essential for BA‐mediated intestine. BA‐activated enhanced uptake epithelial cells by increasing expression GLUT2, which depended ERK1/2 phosphorylation via S1PR2. it also reduced cell energy generation...
Objective: The aim of the study is to screen transcription factor genes related prognosis adult patients with sepsis. Methods: Twenty-three sepsis and 10 healthy individuals admitted for RNA-seq. Differential factors were enriched by four databases, survival analysis was adopted core factors. Then, target submitted STRING constitute protein-protein interaction network. Single-cell technology used localize cell lines. Finally, a transcription-target gene regulation network constituted....
Summary NOD-like receptor pyrin 7 (NLRP7) has been identified as the major gene responsible for recurrent hydatidiform mole (RHM). The immunological role of NLRP7 mutation in HM patients not conclusively demonstrated. Hence, we aim to demonstrate this our study. We followed 12 new with non-synonymous variations (NSVs) from date date. Peripheral blood mononuclear cells (PBMCs) were collected separately and without mutation. Supernatant interleukin (IL)-1β secretion, intracellular pro-IL-1β...
Biliary obstruction diseases are often complicated by an impaired intestinal barrier, which aggravates liver injury. Treatment of the barrier is neglected. To investigate mechanism bile acid deficiency mediates dysfunction after biliary and identify a potential therapeutic modality, we mainly used duct ligation (BDL) mouse model to simulate determine important role receptor FXR in maintaining function stemness. Through RNA-seq analysis BDL sham crypts qRT-PCR performed on epithelial-specific...
Glioblastoma (GBM) is the most common cause of primary brain malignancy. Recently, many immune-related long noncoding ribonucleic acids (ir-lncRNAs) are indicated to be closely related regulation immune microenvironment and cell infiltration GBM.
Background: Liver cancer is a malignant tumor with high morbidity and mortality. Serpin Family E Member 2 (SERPINE2) has been reported to play key role in the metastasis of many tumors; however, potential mechanism SERPINE2 liver not fully explored.Methods: Public databases DNA methylation sequencing were used explore correlation between expression clinical parameters patients. RNA sequencing, IP assay, protein stability ubiquitination assay regulatory cancer.Findings: We identified as...
<div>Abstract<p>Liver cancer is characterized by aggressive growth and high mortality. Asialoglycoprotein receptor 1 (ASGR1), which expressed almost exclusively in liver cells, reduced cancer. However, the specific mechanism of ASGR1 function has not been fully elucidated. On basis database screening, we identified as a tumor suppressor regulated DNA methylation. Expression was downregulated correlated with size, grade, survival. Functional gain loss experiments showed that...
Supplementary Data from Asialoglycoprotein Receptor 1 Functions as a Tumor Suppressor in Liver Cancer via Inhibition of STAT3
Supplementary Data from Asialoglycoprotein Receptor 1 Functions as a Tumor Suppressor in Liver Cancer via Inhibition of STAT3
<div>Abstract<p>Liver cancer is characterized by aggressive growth and high mortality. Asialoglycoprotein receptor 1 (ASGR1), which expressed almost exclusively in liver cells, reduced cancer. However, the specific mechanism of ASGR1 function has not been fully elucidated. On basis database screening, we identified as a tumor suppressor regulated DNA methylation. Expression was downregulated correlated with size, grade, survival. Functional gain loss experiments showed that...
Abstract Background Metastasis serves as the leading cause of treatment failure and cancer-related death in HCC. The role metastasis-associated miRNAs HCC was elusive. Methods Combined analysis TCGA data exosomal miRNA sequencing performed. Expression miR-652-3p assessed. Function experiments TNRC6A were performed both vitro vivo. MRNA sequencing, PCR western blot to verify target genes pathway miR-652-3p. lung metastasis xenograft cancer model nude mice established investigate effects...