A5100624618- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Function and Risk Factors
- Chronic Lymphocytic Leukemia Research
- Ovarian cancer diagnosis and treatment
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Neuropeptides and Animal Physiology
- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- CNS Lymphoma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Fungal Infections and Studies
- Kruppel-like factors research
- Nanocluster Synthesis and Applications
- Acute Lymphoblastic Leukemia research
- Biosimilars and Bioanalytical Methods
- Neuroblastoma Research and Treatments
- Carbon and Quantum Dots Applications
- Viral Infectious Diseases and Gene Expression in Insects
Shenyang Pharmaceutical University
2025
Wenzhou Medical University
2015-2024
First Affiliated Hospital of Wenzhou Medical University
2015-2024
West China Hospital of Sichuan University
2016-2024
Sichuan University
2016-2024
Guangdong Academy of Medical Sciences
2023
Southern Medical University
2023
Guangdong Provincial People's Hospital
2023
Shantou University
2023
Shantou University Medical College
2023
N-Doped carbon dots synthesized by a one-pot solvothermal route displayed tunable luminescence due to different N contents. They could be directly applied in the imaging of peritoneal macrophages mice. This study provides new method tune carbon-based materials through non-metal doping.
While insulin-like growth factor 1 (IGF-1) exerts a cardioprotective effect in the setting of atherosclerosis, binding protein 2 (IGFBP-2) is involved metabolic syndrome. Although IGF-1 and IGFBP-2 are known to be predictors for mortality patients with heart failure, their use clinic as prognostic biomarkers acute coronary syndrome (ACS) requires investigation. We evaluated relationship between levels at admission risk major adverse cardiovascular events (MACEs) ACS.A total 277 ACS 42...
Suppressors of cytokine signaling, SOCS1 and SOCS3, are important negative regulators Janus kinase 2/signal transducers activators transcription which is constitutively activated in myeloproliferative neoplasms (MPNs) leukemia. Curcumin has been shown to possess anticancer activity through different mechanisms. However, whether curcumin can regulate the expression SOCS3 still unknown. Here, we found that elevated via triggering acetylation histone regions promoter K562 HEL cells. As a novel...
Developing multifunctional near-infrared (NIR) light-driven photothermal agents is in high demand for efficient cancer therapy. Herein, PEGylated Cu3BiS3 hollow nanospheres (HNSs) with an average diameter of 80 nm were synthesized through a facile ethylene glycol-mediated solvothermal route. The obtained HNSs exhibited strong NIR optical absorption large molar extinction coefficient 4.1 × 10(9) cm(-1) M(-1) at 980 nm. Under the irradiation laser safe power density 0.72 W cm(-2), produced...
Aiming at the information asymmetry between pharmaceutical enterprises’ technological innovation decisions and government subsidy strategy, this paper establishes a differential game model consisting of single company, proposes three different strategies, obtains an equilibrium solution with help Hamilton-Jacobi-Bellman equation, taking into consideration transmission effect enterprise’s reputation. First, firms without subsidies are analysed, based on this, optimal strategies for...
It is generally believed that there correlation between cancer prognosis and pretreatment PLR NLR. However, are limited data about their role in diffuse large B cell lymphoma (DLBCL). This study aims to determine the prognostic value of NLR for patients who have DLBCL. The associations clinical characteristics were evaluated among 182 DLBCL from January 2005 June 2016. optimal cutoff values high ( ⩾ 150) 2.32) prediction determined. effect on survival was through multivariate Cox regression...
The clinical efficacy of current therapies for Hepatocellular carcinoma (HCC) are unsatisfactory. In recent years, chimeric antigen receptor (CAR) T-cell have been developed solid tumors including advanced HCC (aHCC), but limited progress has made. Glypican-3 is a promising immunotherapeutic target since it specifically highly expressed in HCC. A previous study indicated that GPC3-targeted CAR T-(CAR-GPC3) cells were well-tolerated and had prolonged survival patients Sorafenib could increase...
Abstract Background Iron overload, which is common in patients with haematological disorders, known to have a suppressive effect on haematogenesis. However, the mechanism for this still unclear. The antioxidant curcumin has been reported protect against iron overload-induced bone marrow damage through an as-yet-unknown mechanism. Methods We established overload cell and mouse models. Mitochondrial reactive oxygen species (mROS) levels, autophagy levels SIRT3/SOD2 pathway were examined models...
// Shujuan Zhou 1 , Fang Huiyao Chen Wei Zhang Yang Yifen Shi Zhouyi Zheng 2 Yongyong Ma Liyuan Tang Jianhua Feng Yu Lan Sun Yi Bin Liang Kang and Songfu Jiang Department of Hematology, The First Affiliated Hospital Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China Hematology oncology, Traditional Chinese Zhuji, Shaoxing, Correspondence to: Jiang, email: 20442947@qq.com Yu, yukang@163.com Keywords: diffuse large B cell lymphoma, red blood distribution width, prognosis, survival...
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Circular RNAs (circRNAs) play a vital role in diabetic peripheral neuropathy. However, their expression and function Schwann cells individuals with neuropathy remain poorly understood. Here, we performed protein profiling circRNA sequencing of sural nerves patients controls. Protein revealed 265 differentially expressed proteins the group. Gene Ontology indicated that were mainly enriched myelination mitochondrial oxidative phosphorylation. A real-time polymerase chain reaction assay to...
To determine the prognostic value of baseline mean platelet volume (MPV) in diffuse large B-cell lymphoma (DLBCL) patients. We retrospectively analyzed 161 DLBCL patients who received R-CHOP chemotherapy. The associations between MPV and clinicopathological factors were assessed. A low (MPV ≤ 9.1 fl, cut-off was calculated by receiver operating characteristics) not associated with any other factors. Patients fl experienced a shorter progression-free survival (PFS) (2-year PFS rate, 60.6% vs...
One of the approaches to make anti-CD20 antibody more efficient is express this on surface T cells. scFv from has been expressed cell bind CD20 positive cells and CD3zeta as a fusion partner transduct signals. grafted with chimeric scFv/CD3zeta were able redirect an MHC/Ag-independent antitumor response. To test effects CD28 signal cellular activation effectiveness modified cells, we constructed recombinant scFv/CD28/CD3zeta gene in retroviral vector. expressing specifically lysed target...
Background: Currently, the optimal maintenance therapy for patients with acute promyelocytic leukemia (APL) who have achieved complete remission (CR) after completing consolidation chemotherapy remains controversial. The comparative effectiveness of all-trans retinoic acid (ATRA) plus arsenic trioxide (As 2 O 3 ) strategy classic ATRA has not been evaluated. In this study, we compared efficacy and toxicity As in low- to intermediate-risk APL reaching first CR induction therapy. Methods: A...
Background Uncontrolled blood pressure ( BP ) is commonly observed in patients receiving antihypertensive agents. However, its relationship with early left ventricular LV dysfunction has not been elucidated. Methods This study enrolled 276 treated hypertension and 85 healthy controls. The 140/90 mm Hg was used to define controlled HT 1 group, n=145) or uncontrolled 2 n=131) according the concurrent guidelines. myocardial function assessed by two‐dimensional speckle tracking imaging,...