A5068602114- Inflammatory Biomarkers in Disease Prognosis
- Lymphoma Diagnosis and Treatment
- Microfluidic and Bio-sensing Technologies
- Protein Degradation and Inhibitors
- Lymphatic System and Diseases
- Innovation and Socioeconomic Development
- Urologic and reproductive health conditions
- Acute Myeloid Leukemia Research
- Protein purification and stability
- Epigenetics and DNA Methylation
- Antioxidant Activity and Oxidative Stress
- Viral Infectious Diseases and Gene Expression in Insects
- Retinoids in leukemia and cellular processes
- Histone Deacetylase Inhibitors Research
Wenzhou Medical University
2016-2017
First Affiliated Hospital of Wenzhou Medical University
2016-2017
// Shujuan Zhou 1 , Fang Huiyao Chen Wei Zhang Yang Yifen Shi Zhouyi Zheng 2 Yongyong Ma Liyuan Tang Jianhua Feng Yu Lan Sun Yi Bin Liang Kang and Songfu Jiang Department of Hematology, The First Affiliated Hospital Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China Hematology oncology, Traditional Chinese Zhuji, Shaoxing, Correspondence to: Jiang, email: 20442947@qq.com Yu, yukang@163.com Keywords: diffuse large B cell lymphoma, red blood distribution width, prognosis, survival...
To determine the prognostic value of baseline mean platelet volume (MPV) in diffuse large B-cell lymphoma (DLBCL) patients. We retrospectively analyzed 161 DLBCL patients who received R-CHOP chemotherapy. The associations between MPV and clinicopathological factors were assessed. A low (MPV ≤ 9.1 fl, cut-off was calculated by receiver operating characteristics) not associated with any other factors. Patients fl experienced a shorter progression-free survival (PFS) (2-year PFS rate, 60.6% vs...
Dysfunction of histone acetylation inhibits topoisomerase IIα (Topo IIα), which is implicated in benzene-induced hematotoxicity patients with chronic benzene exposure. Whether deacetylase (HDAC) inhibitors can relieve remains unclear. Here we showed that hydroquinone, a main metabolite benzene, increased the HDAC activity, decreased Topo expression and induced apoptosis human bone marrow mononuclear cells vitro, treatment two inhibitors, namely trichostatin A (TSA) or mixture...
Background: Currently, the optimal maintenance therapy for patients with acute promyelocytic leukemia (APL) who have achieved complete remission (CR) after completing consolidation chemotherapy remains controversial. The comparative effectiveness of all-trans retinoic acid (ATRA) plus arsenic trioxide (As 2 O 3 ) strategy classic ATRA has not been evaluated. In this study, we compared efficacy and toxicity As in low- to intermediate-risk APL reaching first CR induction therapy. Methods: A...
Abstract The emergence of nucleic acid medicine (NAM) has profoundly addressed global infectious disease challenges 1 and revolutionized cancer therapy 2 gene-editing 3 . However, current NAM, such as mRNA vaccine, remains distant from customizable supply is fraught with hurdles thermo-instability infrastructure dependence. Drawing inspiration the efficiency capsule coffee machines, we introduce a Rapid On-site Microfluidic Assembly (ROMA) prototype capable generating ready-to-inject...
<title>Abstract</title> Despite achieving unprecedented success, current mRNA vaccines face significant challenges, including thermo-instability, degradation, and infrastructure-dependence, making customizable supply a distant goal. Here, we describe Rapid Onsite Microfluidic Assembly (ROMA) technology capable of generating ready-to-inject with real-time quality inspection as solution. Diverging from traditional manufacturing mechanism directly assembling lipids into mRNA-LNPs, ROMA utilizes...