A5034158183- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Organ Transplantation Techniques and Outcomes
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Ginseng Biological Effects and Applications
- Eosinophilic Esophagitis
- Pancreatic and Hepatic Oncology Research
- Clinical Nutrition and Gastroenterology
- Hepatitis B Virus Studies
- Inflammatory Bowel Disease
- Mycobacterium research and diagnosis
- Helicobacter pylori-related gastroenterology studies
- Hydrogen's biological and therapeutic effects
- Hepatocellular Carcinoma Treatment and Prognosis
- Biomedical Ethics and Regulation
- Lymphatic Disorders and Treatments
- Ferroptosis and cancer prognosis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cancer Immunotherapy and Biomarkers
Harbin Medical University
2013-2024
Second Affiliated Hospital of Harbin Medical University
2012-2024
Yanbian University
2022
Heilongjiang Provincial Hospital
2013
First Hospital of Jilin University
2012
Jilin University
2012
Background: Ulcerative colitis (UC) is an intestinal inflammatory disease that strongly associated with mitochondrial damage and dysfunction as well mitophagy lacks of satisfactory treatments.Hair follicle mesenchymal stem cell (HF-MSC)-derived exosomes owe benefit effectiveness on therapies.Hypoxia-preconditioned HF-MSCs exhibit enhanced proliferation migration abilities, their exert stronger effects than normal exosomes.However, the therapeutic function Hy-Exos in UC unknown.Methods: The...
Hair follicle-derived mesenchymal stem cells (HF-MSCs) show considerable therapeutic potential for liver cirrhosis (LC). To improve the effectiveness of naïve HF-MSC treatments on LC, we used bioinformatic tools to identify an exogenous gene targeting HSCs among differentially expressed genes (DEGs) in LC modify HF-MSCs. Extracellular matrix protein 1 (ECM1) was identified as a DEG that significantly downregulated cirrhotic liver. Then, ECM1-overexpressing HF-MSCs (ECM1-HF-MSCs) were...
Ginsenoside Rd (GRd) is a biologically active component of ginseng that stimulates the proliferation endogenous stem cells. The objective our research was to evaluate utility GRd in gastrointestinal mucosal regeneration rat model inflammatory bowel disease (IBD) and clarify whether exerts its pharmacological effects by modulating intestinal IBD established via subcutaneous injection indomethacin, 10, 20, or 40 mg/kg an equal volume physiological saline then administered orally rats different...
Abstract Background Ulcerative colitis (UC) is a chronic and recurrent disease without satisfactory treatment strategies. Dental pulp stem cell (DPSC) transplantation has been proposed as potential therapy for UC. This study aimed to investigate the therapeutic effects of rat hepatocyte growth factor (HGF) gene transduced into DPSCs Methods The HGF-DPSCs transplanted intravenously model UC induced by 5% dextran sulphate sodium (DSS) were compared with other groups (LV-HGF group, group...
Background. Colorectal cancer (CRC) is one of the commonest cancers worldwide. As conventional biomarkers cannot clearly define heterogeneity CRC, it essential to establish novel prognostic models. Methods. For training set, data pertaining mutations, gene expression profiles, and clinical parameters were obtained from Cancer Genome Atlas. Consensus clustering analysis was used identify CRC immune subtypes. CIBERSORT analyze across different subgroups. Least absolute shrinkage selection...
Abstract Dental pulp stem cell (DPSC) transplantation has been demonstrated to promote the regeneration and repair of tissues organs is a potentially effective treatment for radioactive esophageal injury. In this study, explore therapeutic effects DPSCs on acute radiation-induced injury, were cultured transplanted into rats with injuries induced by 125 I seeds in vivo. injured esophagus, PKH26-labeled co-localized PCNA, CK14, CD71, integrin α6, expression levels these four makers cells...
Researchers increasingly report the therapeutic effect of exosomes derived from rat bone marrow mesenchymal stem cells (Exos-rBMMSC) on liver disease, while optimal dose Exos-rBMMSC in cirrhotic treatment has not been reported. In this study, we aimed to explore efficacy and a hepatic cirrhosis model. The effects low dose, medium high were assessed by function tests histopathology. After four-weeks therapy, pyroptosis-related expression levels groups significantly decreased compared those...
Ulcerative colitis (UC) has attracted intense attention due to its high recurrence rate and the difficulty of treatment. Pyroptosis been suggested be crucial in development UC. Although mesenchymal stem cells (MSCs) are broadly used for UC therapy, they have rarely studied context pyroptosis. Hair follicle-derived MSCs (HFMSCs) especially understudied with regard In this study, we aimed discover effects potential mechanisms HFMSCs We administered dextran sulfate sodium- (DSS-) treated mice...
Stem cell transplantation has theoretical potential for the treatment of certain liver diseases. However, use bone marrow mononuclear cells as a therapy disease received little attention. The present study was to examine whether might be useful in management acute failure an animal model. MATERIALS AND METHOTS: Bone were harvested from BALB/c mice and then labeled with fluorescent dye PKH26. subsequently infused into tail veins which hepatic injury had been induced by CCl4 toxicity. After...
Cirrhosis is the terminal stage of hepatic diseases and prone to develop into hepatocyte carcinoma. Increasing evidence suggests that transplantation dental pulp stem cells (DPSCs) may promote recovery from cirrhosis, but key regulatory mechanisms involved remain be determined. In this study, we overexpressed human growth factor (hHGF) in primary rat DPSCs evaluated effects HGF overexpression on biological behaviors therapeutic efficacy grafted cirrhosis. Liver cirrhosis was induced via...
The aim of this study was to determine the optimal volume peritoneal effusion required diagnose malignant ascites.The authors recruited 123 patients with shifting dullness and obtained peritoneocentesis fluid samples. samples were divided into seven aliquots 10, 50, 100, 150, 200, 250, 300 mL for cytopathological examination. sensitivity, specificity, negative predictive value (NPV), positive (PPV) calculated each aliquot.The sensitivity diagnosis ascites gradually increased as sample...
Liver cirrhosis (LC), the major pathway for progression and development of chronic liver disease, is an advanced stage disease. It third most common noncommunicable disease after cardiovascular diseases malignant tumors. Tanshinone IIA (Tan), extract Salvia miltiorrhiza (S. miltiorrhiza), has been proven to promote proliferation differentiation stem cells. Moreover, its protective effect in injury received widespread attention. The present study investigated whether Tan plays a therapeutic...
Hepatocellular carcinoma (HCC) represents a common neoplasm that presents substantial worldwide health challenge. Nevertheless, the involvement of HPN-AS1 in HCC remains unknown. The quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay was utilized to measure expression HCC. GABPA effects on promoter were analyzed through chromatin immunoprecipitation and luciferase reporter assays. Cell proliferation potential determined by deploying CCK-8 assay, Ki-67...
Esophageal cancer (EC) is one of the commonest human cancers, which accompany high morbidity. MicroRNAs (miRNAs) play a pivotal role in various including EC. Our research aimed to reveal function and mechanism miR-135b-5p. identified that miR-135b-5p was elevated EC samples from TCGA database. Correspondingly real-time PCR assay also showed higher expressed Eca109, EC9706, KYSE150 cells than normal esophageal epithelial (Het-1A). CCK8, Edu, wound healing, Transwell assay, western blot...
Background: Small intestinal ischemia-reperfusion (IR) injury is a common disease with high morbidity and mortality. Mesenchymal stem cells (MSCs) have been increasingly used in various diseases. This study aimed to evaluate the therapeutic effect of hair follicle MSCs (HFMSCs) on small IR injury. Methods: We divided Sprague-Dawley rats into three groups: sham group, group + HFMSCs group. A rat model was established by clamping superior mesenteric artery (SMA) for 30 min reperfusion 2 h....
Bone marrow mesenchymal stromal cells (BMSCs) have a protective effect against liver cirrhosis. Long noncoding RNAs (lncRNAs) play crucial roles in the progression of Therefore, it is aimed to clarify lncRNA Kcnq1ot1 involved mechanism BMSCs This study found that treatment attenuates CCl4 -induced cirrhosis mice. Additionally, expression upregulated human and mouse tissues, addition TGF-β1-treated LX2 JS1 cells. The reversed with treatment. knockdown alleviated both vivo vitro. Fluorescence...
Researchers have shown that bone mesenchymal stem cells (BMSCs) can alleviate the progression of liver cirrhosis; however, it is unclear how exactly BMSCs function to cure disease. In this study, we used bioinformatics methods assess differentially expressed genes (DEGs) in cirrhosis and found a significantly upregulated gene, Fstl1, cirrhosis. vivo vitro experiments showed compared with those disease model group, mRNA, protein expression levels Fstl1 were reduced after treatment, β-Catenin...
Gastric Cancer (GC) is a common cancer worldwide with high morbidity and mortality rate in Asia. Many prognostic signatures from genes non-coding RNA (ncRNA) levels have been identified by high-throughput expression profiling for GC. To date, there no reports on integrated optimization analysis based the GC global lncRNA-miRNA-mRNA network mechanism has not studied. In present work, specific regulatory (GCsLMM) was constructed ceRNA hypothesis combining miRNA-target interactions data of mine...
Abstract Monitoring extent and severity is vital in the ulcerative colitis (UC) follow-up, however, current assessment complex low cost-effectiveness. We aimed to develop a routine blood-based clinical decision support tool, Jin’s model, investigate of UC. The multicentre retrospective cohort study recruited 975 adult UC inpatients sub-grouped into training, internal validation external set. Model was developed by logistics regression for via Montreal classification Mayo score, Truelove...
Liver cirrhosis (LC) involves multiple systems throughout the body, and patients with LC often die of organ failure. However, few drugs are useful to treat LC. Hair follicle mesenchymal stem cells (HF-MSCs) derived from dermal papilla bulge area hair follicles pluripotent in mesoderm broad prospects regenerative medicine. As an emerging seed cell type widely used skin wound healing plastic surgery, HF-MSCs show considerable treatment due their proliferation multidirectional differentiation...