A5048347786- Anesthesia and Neurotoxicity Research
- Diet and metabolism studies
- Diabetes Treatment and Management
- Ovarian function and disorders
- Aortic aneurysm repair treatments
- Cell Adhesion Molecules Research
- Alzheimer's disease research and treatments
- Respiratory viral infections research
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Hepatitis B Virus Studies
- Influenza Virus Research Studies
- Hepatitis C virus research
- Kruppel-like factors research
- Neuroinflammation and Neurodegeneration Mechanisms
- Obesity, Physical Activity, Diet
- Neurogenesis and neuroplasticity mechanisms
- Anesthesia and Sedative Agents
- Nutritional Studies and Diet
- Autophagy in Disease and Therapy
- Grit, Self-Efficacy, and Motivation
- Hair Growth and Disorders
- Vitamin D Research Studies
- Metabolism and Genetic Disorders
- Hepatitis Viruses Studies and Epidemiology
China University of Mining and Technology
2025
First Affiliated Hospital of Jiangxi Medical College
2024
Nanchang University
2021-2024
Sichuan University
2015-2024
West China Second University Hospital of Sichuan University
2016-2024
First Affiliated Hospital of Nanchang University
2021-2023
National Clinical Research Center for Digestive Diseases
2023
Anhui Medical University
2019-2022
UNSW Sydney
2021-2022
Harbin Medical University
2022
The number of obese people continues to increase worldwide, and obesity-related complications add every country's health burden. Consequently, new weight-loss medications, such as glucagon-like peptide-1 receptor agonists (GLP-1RAs), are attracting increasing attention. This study sought assess the cost effectiveness for weight loss 4 GLP-1RAs in adult patients with obesity United States.Four GLP-1RA groups that received Liraglutide (1.8 mg QD), Semaglutide (1.0 QW), Dulaglutide (1.5 or...
Emissions from domestic coal burning are generally recognized as the cause of lung cancer epidemic in Xuanwei City, Yunnan Province, China. To examine physicochemical characteristics airborne particles emitted this locally sourced coal, PM2.5 samples were collected Hutou village which has high levels cancer, and Xize located approximately 30 km without cases. Transmission Electron Microscopy-Energy Dispersive X-ray (TEM-EDX) analysis was employed to study physiochemical features chemistry...
The role of serum albumin in the risk diabetic peripheral neuropathy (DPN) remains unclear. This study aimed to explore relationship between level and DPN, examine any possible effect modifiers among patients with type 2 diabetes mellitus.This cross-sectional was conducted Jiangxi, China, from May 2012 December 2014. Serum levels were determined 523 subjects, association DPN evaluated using linear regression models (odds ratio [OR] corresponding 95% confidence interval [CI]).There a...
Background Mainland China experienced pandemic influenza H1N1 (2009) virus (pH1N1) with peak activity during November-December 2009. To understand the geographic extent, risk factors, and attack rate of pH1N1 infection in we conducted a nationwide serological survey to determine prevalence antibodies pH1N1. Methodology/Principal Findings Stored serum samples (n = 2,379) collected 2006-2008 were used estimate baseline reactogenicity In January 2010, multistage-stratified random sampling...
Cellular function phenotype is regulated by various microRNAs (miRs), including miR-135a. However, how miR-135a involved in the calcification senescent vascular smooth muscle cells (VSMCs) not clear yet. In present study, we first identified significantly altered miRNAs VSMCs, then performed consecutive passage culture of VSMCs and analyzed expression miR- 135a genes phase. Next, effects inhibition on were analyzed. The luciferase assay was used to validate target protein western blotting...
Sevoflurane (Sevo) prevents hypoxia/reoxygenation (H/R)-induced cardiomyocytes apoptosis. MiR-27a-3p expression is up-regulated in Sevo-treated hippocampal neurons.This study explored whether the effect of Sevo on was mediated by miR-27a-3p.The were cultured under H/R condition or pre-treated with Sevo, and further transfected miR-27a-3p inhibitor treated an autophagy 3-methyladenine (3-MA). Then cell morphology observed optical microscope. The viability apoptosis measured MTT flow...
Dipeptidyl peptidase-4 (DPP-4) inhibitors have been considered as incretin-based agents that signal through GLP-1R. Our high-throughput RNA sequencing (RNA-seq) and bioinformatics methods indicated GLP-1R, downregulated in diabetes mellitus (DM), was a potential target of DPP-4 inhibitors, which further confirmed DM rats. Thus, this study illuminated the alleviatory mechanism on cognitive dysfunction may be associated with GLP-1R signaling. rats were administered Chloroquine (an autophagy...
Polycystic ovary syndrome (PCOS) is a common, multifactorial disorder characterized by endocrine, reproductive, and metabolic dysfunction. As the etiology of PCOS unknown, there no cure symptom-oriented treatments are suboptimal. Hyperandrogenism key diagnostic trait, evidence suggests that androgen receptor (AR)-mediated actions critical to pathogenesis. However, AR target sites involved remain be fully defined. Adipocyte muscle dysfunction proposed as important in manifestation traits. We...
Abstract Resveratrol (RSV) has been shown to have a neuroprotective effect in various central nervous system disorders, although the role of RSV diabetes‐induced cognitive dysfunction is still not fully elucidated. Here, we investigated whether improved diabetes‐related vivo and vitro. We induced rat diabetic model with high‐fat high‐sucrose diet followed by intraperitoneal injection streptozotocin neuron cell stimulation high levels glucose. observed that impairment spatial learning memory...
Estrogen induces oligodendrocyte remyelination in response to demyelination the central nervous system. Our objective was determine effects of 17β-estradiol (E2) on Schwann cell function and peripheral nerve after injury. Adult male C57BL/6J mice were used prepare sciatic transection injury model randomly categorized into control E2 groups. To study myelination vitro, dorsal root ganglion (DRG) explant culture prepared using 13.5-day-old mouse embryos. Primary cells isolated from nerves 1-...
Background During the 2009 pandemic influenza H1N1 (2009) virus (pH1N1) outbreak, school students were at an increased risk of infection by pH1N1 virus. However, estimation attack rate showed significant variability. Methods Two outbreaks investigated in this study. A questionnaire was designed to collect information interview. Throat samples collected from all subjects study 6 times and sero 3 confirm determine viral shedding. Data analysis performed using software STATA 9.0. Findings The...
Postoperative cognitive dysfunction (POCD) in elderly patients undergoing general anesthesia is a major problem the aging society. Sevoflurane most widely applied anesthetic clinical practice. In this study, we investigated effects of GLP-1 analogue liraglutide on function aged rats anesthetized by sevoflurane. Specifically, 48 Sprague-Dawley were divided into control (C) group, (L) sevoflurane (S) and sevoflurane+liraglutide (SL) each group with 12 rats. S SL injected subcutaneously normal...
Immunogenicity of a New Flaviviral-Based DNA Launched Suicidal Replicon for Protective Vaccination Against Hepatitis C
Abstract Diabetes‐induced cognitive dysfunction (DCD) is a neurological disorder associated with diabetes, characterized by impairment driven neuronal injury from chronic high glucose (HG) exposure. This study aims to elucidate the role and mechanisms of X‐linked inhibitor apoptosis protein (XIAP)/thioredoxin‐interacting (TXNIP) in hippocampal neuron cell death function within DCD models. A diabetic rat model was established using high‐fat/sucrose diet streptozotocin injection. Primary...
To investigate the causal associations between components of metabolic syndrome (MetS) and endometrial carcinoma using Mendelian randomization (MR). Data mining Genome-Wide Association Studies (GWAS) database was performed, with exposure factors being MetS (lipids, blood pressure, glucose, obesity) outcome factor carcinoma. MR analyses were performed help regression models, including MR-Egger method, weighted median inverse variance (IVW) relationship evaluated by odds ratio (OR). Reverse...
Diabetes-associated cognitive dysfunction is a major problem of the international community. Dipeptidyl peptidase-4 (DPP-4) inhibitors are drugs with hypoglycemic effect widely used in diabetic treatment clinic. In this article, we studied DPP-4 inhibitor saxagliptin on function rats. Firstly, to observe caused by diabetes, built rat model. Subsequently, diabetes was evaluated Morris Water Maze Task. Thirdly, mechanism alleviation investigated. Specifically, (1) anti-inflammation revealed...
Objective To explore the influence of home nursing intervention on adverse events and ability caregivers in cerebrovascular disease nasal patients with indwelling gastric tube. Methods Totals 63 cases feeding discharge from September 2011 to August 2012 our department were selected as control group 68 2013 group. The general information two groups, incidence mucosa mechanical injury complications tube retrospectively analyzed. relevant knowledge compared. Results The incidences...
Abstract Background: Obesity and weight gain are associated with higher rates of breast cancer recurrence increased mortality. Cardiovascular disease is a leading cause death in survivors. Control body cardiovascular risk factors key aspects survivorship. The purpose our study was to see if low carbohydrate, calorie restricted dietary intervention could be implemented group obese postmenopausal survivors achieve loss improved lipid profiles. Methods: Twenty-four estrogen receptor positive...
To investigate the correlation between serum vitamin D levels and index of glucose lipid metabolism in postmenopausal women with type 2 diabetes mellitus (T2DM).A total 44 T2DM 41 healthy were matched age, body mass menopausal duration. The was detected by enzyme-linked immuno-sorbent assay (ELISA).Compared control group, level 25(OH)D3 lower, no statistical significance. Multiple regression analysis revealed that only BMI(bj'=-0.372, P<0.05) independently related to percentages deficiency...