A5064503279- Pancreatic function and diabetes
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Atherosclerosis and Cardiovascular Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Cholesterol and Lipid Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Cell Adhesion Molecules Research
- Diabetes Management and Research
- Central Venous Catheters and Hemodialysis
- Diabetes Treatment and Management
- Diet and metabolism studies
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Drug Transport and Resistance Mechanisms
- Protease and Inhibitor Mechanisms
- Diet, Metabolism, and Disease
- Blood Coagulation and Thrombosis Mechanisms
- Medical Imaging Techniques and Applications
- Human-Animal Interaction Studies
- Cell Image Analysis Techniques
UNSW Sydney
2015-2024
National University of Singapore
2024
The University of Sydney
2014-2022
The Heart Research Institute
2012-2020
Imperial College London
2018
Colorado State University
2018
Columbia University
2018
University of Chicago
2018
California Institute of Technology
2018
Leibniz Institute for Catalysis
2018
Glucagon-like peptide-1 receptor (GLP-1R) activation promotes insulin secretion from pancreatic beta cells, causes weight loss, and is an important pharmacological target in type 2 diabetes (T2D). Like other G protein-coupled receptors, the GLP-1R undergoes agonist-mediated endocytosis, but functional therapeutic consequences of modulating endocytic trafficking have not been clearly defined. Here, we investigate a series biased agonists with variable propensities for internalization...
Background Release of neutrophil extracellular traps (NETs) after percutaneous coronary intervention (PCI) in acute syndrome (ACS) is associated with periprocedural myocardial infarction, as a result microvascular obstruction via pro‐inflammatory and prothrombotic pathways. Colchicine well‐established anti‐inflammatory agent growing evidence to support use patients disease. However, its effects on post‐PCI NET formation ACS have not been explored. Methods Results Sixty (40 ACS; 20 stable...
Abstract Therapeutic interventions that increase plasma high density lipoprotein (HDL) and apolipoprotein (apo) A-I levels have been reported to reduce glucose attenuate insulin resistance. The present study asks if this is a direct effect of increased uptake by skeletal muscle. Incubation primary human muscle cells (HSKMCs) with apoA-I insulin-dependent insulin–independent in time- concentration-dependent manner. was accompanied enhanced phosphorylation the receptor (IR), substrate-1...
Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly pure dingo (CanFam_DDS). We identified large chromosomal differences relative to current dog reference (CanFam3.1) confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using...
Prostate cancer growth is driven by androgen receptor signaling, and advanced disease initially treatable depleting circulating androgens. However, prostate cells inevitably adapt, resulting in relapse with incurable castrate-resistant cancer. Androgen deprivation therapy has many side effects, including hypercholesterolemia, more aggressive cancers typically feature cellular accumulation of cholesterol stored the form cholesteryl esters. As a key substrate for de novo steroidogenesis cells,...
Objective— Therapeutic interventions that increase plasma levels of high-density lipoproteins and apolipoprotein A-I (apoA-I) A-I, the major lipoprotein apolipoprotein, improve glycemic control in people with type 2 diabetes mellitus. High-density apoA-I also enhance insulin synthesis secretion isolated pancreatic islets clonal β-cell lines. This study identifies signaling pathways mediate these effects. Approach Results— Incubation increased cAMP accumulation Ins-1E cells a...
Calorie restriction is a first-line treatment for overweight individuals with metabolic impairments. However, few patients can adhere to long-term calorie restriction. An alternative approach that also causes negative energy balance mitochondrial uncoupling, which decreases the amount of be extracted from food. Herein we compare effects uncoupler BAM15 in db/db mouse model severe hyperglycemia, obesity, hypertriglyceridemia, and fatty liver. Male mice were treated ∼50% restriction, at two...
BACKGROUNDCytochrome P450 family 8 subfamily B member 1 (CYP8B1) generates 12α-hydroxylated bile acids (BAs) that are associated with insulin resistance in humans.METHODSTo determine whether reduced CYP8B1 activity improves sensitivity, we sequenced individuals without diabetes and identified carriers of complete loss-of-function (CLOF) mutations utilizing functional assays.RESULTSMutation had lower plasma 12α-hydroxylated/non-12α-hydroxylated BA cholic acid (CA)/chenodeoxycholic (CDCA)...
Elevated pancreatic β-cell cholesterol levels impair insulin secretion and reduce plasma levels. This study establishes that low have a detrimental effect on two major target tissues: adipose tissue skeletal muscle. Mice with increased were generated by conditional deletion of the ATP-binding cassette transporters, ABCA1 ABCG1, in β-cells (β-DKO mice). Insulin was impaired these mice under basal high-glucose conditions, glucose disposal shifted from muscle to tissue. The β-DKO also had body...
Abstract Cholesterol is considered indispensable for cell motility, but how physiological cholesterol pools enable cells to move forward remains be clarified. The majority of obtain from the uptake Low-Density lipoproteins (LDL) and here we demonstrate that LDL stimulates A431 squamous epithelial carcinoma Chinese hamster ovary (CHO) migration invasion. also potentiated epidermal growth factor (EGF) -stimulated as well invasion in 3-dimensional environments, using organotypic assays....