A5018857467- Infant Nutrition and Health
- Probiotics and Fermented Foods
- Intestinal Malrotation and Obstruction Disorders
- Gut microbiota and health
- Clinical Nutrition and Gastroenterology
- Viral gastroenteritis research and epidemiology
- Genomics and Phylogenetic Studies
- Human-Animal Interaction Studies
- Child Nutrition and Water Access
- Genetic diversity and population structure
- Immune Response and Inflammation
- Cancer Research and Treatments
- Evolutionary Game Theory and Cooperation
- Evolution and Genetic Dynamics
- Microplastics and Plastic Pollution
- Wildlife Ecology and Conservation
- Plant and animal studies
- Antimicrobial Peptides and Activities
- Medical and Biological Ozone Research
- Microbial Metabolites in Food Biotechnology
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- biodegradable polymer synthesis and properties
UNSW Sydney
2012-2024
The University of Western Australia
2023
Baptist Memorial Hospital for Women
2023
Nanyang Technological University
2023
King Edward Memorial Hospital
2023
Environmental Earth Sciences
2020-2022
Background Probiotic supplementation significantly reduces the risk of necrotising enterocolitis (NEC) and all cause mortality in preterm neonates. Independent quality assessment is important before introducing routine probiotic this cohort. Aim To assess product quality, confirm that Bifidobacterium breve (B. breve) M-16V will increase fecal B. counts without adverse effects. Methods Participants Strain identity (16S rRNA gene sequencing), viability over 2 year shelf-life were confirmed,...
Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly pure dingo (CanFam_DDS). We identified large chromosomal differences relative to current dog reference (CanFam3.1) confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using...
Objective Evidence indicates that multistrain probiotics benefit preterm infants more than single-strain (SS) probiotics. We assessed the effects of SS versus triple-strain (TS) probiotic supplementation (PS) in extremely (EP) infants. Design EP (gestational age (GA) <28 weeks) were randomly allocated to TS or probiotic, assuring blinding. Reference (REF) group was placebo arm our previous trial. PS commenced with feeds and continued until 37 weeks’ corrected GA. Primary outcome time full...
Lactobacillus strains have shown efficacy in attenuating inflammation. This study evaluated the potential of fermentum PC1 for treatment rheumatoid arthritis (RA) using a murine model collagen-induced arthritis. On Day 1, healthy DBA/1 mice (six to eight weeks age) were immunized, with 100 μg Chicken Type 11 collagen emulsified complete Freund's adjuvant (CFA) by intradermal injection, at base tail. 21, immunized intraperitoneally Bovine Type11 phosphate buffered saline (PBS). 28, 50...
Gut development, function and colonisation are impaired in animal models of prematurity with intrauterine growth restriction (IUGR). The effect Bifidobacterium breve (B. breve) supplementation on faecal bifidobacteria small for gestational age (SGA: birth weight <10th centile due to IUGR) preterm infants is not known.We compared B. M-16V (<33 weeks) SGA versus non-SGA the two arms our randomised controlled trial.There were no baseline differences proportion detectable counts between...
This study examined the influences of dosage adjuvant, nature antigen and host genetics on capacity L. fermentum PC1 (PC1) to function as an oral adjuvant. BALB/c DBA/1 mice were vaccinated with either ovalbumin (OVA) or Salmonella Typhimurium days 0 14, Mice also dosed (10⁸ CFU 10(11) per dose mouse) antigens (days 14) alone -1 13). The higher elicited a greater specific serum IgG2a response than IgG1 for both strains, indicating Th1-biased humoral immune response. Th1 bias was observed at...
It is well established that polyethylene (PE) wear particles induce macrophage production of cytokines and mediators associated with the pathogenesis inflammatory osteolysis. The objective this study was to examine potential three Lactobacillus strains attenuate TNF-α cytokine response macrophages exposed Ceridust 3615 PE particles. An in vitro experimental model using RAW 246.7 cell line utilized.Lactobacillus were found modulate a strain dose specific manner. Only acidophilus tested able...
Background Heat-inactivated probiotics (HPs) may provide an effective alternative to live (P) by avoiding their risks (eg, probiotic sepsis) while retaining the benefits. We assessed safety and efficacy of a HP in very preterm (VP: gestation <32 weeks) infants. Methods VP infants were randomly allocated receive or P mixture ( Bifidobacterium breve M-16V, longum subsp. infantis M-63, BB536, total 3×10 9 CFU/day) assuring blinding. Primary outcome was faecal calprotectin (FCP) levels...
Abstract The dingo is Australia’s iconic top-order predator and arrived on the continent between 5,000-8,000 years ago. To provide an unbiased insight into its evolutionary affiliations biological interactions, we coupled long-read DNA sequencing with a multiplatform scaffolding approach to produce ab initio genome assembly of desert (85X coverage) call CanLup_DDS. We compared this Boxer (CanFam3.1) German Shepherd dog (CanFam_GSD) assemblies characterized lineage-specific shared genetic...
Abstract Background Heat-inactivated probiotics may provide an effective alternative to live by avoiding the risk of probiotic sepsis, altered immune responses and antimicrobial resistance while retaining benefits. Objective We assessed safety efficacy a heat-inactivated in very preterm (VP: gestation < 32 weeks) infants. Methods VP infants were recruited including pre-planned subgroup extremely (EP: 28 weeks). Mixture (HP) or (P) strains B. breve M-16V, longum subsp. infantis M-63, BB536...
Lactobacillus strains have been shown to confer health benefits the host including attenuation of intestinal inflammatory responses. However, lactobacilli are strain specific. The aim this study was determine whether <i>Lactobacillus fermentum</i> PC1 (PC1) cell wall extract (CW) and spent culture supernatant (SCS) had capacity inhibit IL-8 production by <i>Salmonella</i> <i>enterica </i>serotype Typhimurium (<I>S</I>. Typhimurium) infected epithelial cells. Epithelial line, HT-29 treated...