A5101465957- Pancreatic function and diabetes
- Mesenchymal stem cell research
- Advanced Glycation End Products research
- Diabetic Foot Ulcer Assessment and Management
- Metabolism, Diabetes, and Cancer
- Wound Healing and Treatments
- Diabetes and associated disorders
- Air Quality and Health Impacts
- Hippo pathway signaling and YAP/TAZ
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Diabetes Management and Research
- Immune cells in cancer
- Cardiac Fibrosis and Remodeling
- Psoriasis: Treatment and Pathogenesis
- Endoplasmic Reticulum Stress and Disease
- Diabetes Treatment and Management
- Cancer Immunotherapy and Biomarkers
- HIV Research and Treatment
- Lipid metabolism and disorders
- Case Reports on Hematomas
- Cancer, Lipids, and Metabolism
Nanchang University
2009-2023
First Affiliated Hospital of Nanchang University
2009-2023
Shanghai Public Health Clinical Center
2017-2023
Yuxian People's Hospital
2021
Xiangya Hospital Central South University
2019-2020
Central South University
2019-2020
Sun Yat-sen University
2011-2019
Creative Commons
2017
Nankai University
2017
Biocon (Switzerland)
2010
The proinflammatory IL-17-producing CD8(+) T cells (Tc17 cells) have recently been detected in tumors, but the nature and regulation of these human tumors are presently unknown. We found that IL-17(+) accumulated hepatocellular carcinomas (HCC), where they promote disease progression by fostering angiogenesis. In this study, we showed Tc17 constitute a remarkable portion HCC. Although most circulating were negative for IFN-gamma, >80% HCC tissues positive enriched predominantly invading...
Substantial evidence indicates that inflammation is a critical component of tumor progression. The proinflammatory IL-17-producing cells have recently been detected in tumors, but the effect IL-17 on antigen-presenting tumors presently unknown. We found B7-H1(+) macrophages (Mφs) were enriched predominantly peritumoral stroma hepatocellular carcinomas (HCCs). Here, we positive correlation between and B7-H1-expressing Mφs same area. monocytes/Mφs from HCC tissues expressed significantly more...
Diabetic foot (DF) is a common complication of high severity for diabetes, prevalent metabolic disorder that affects billions people worldwide.Mesenchymal stem cells (MSCs) have demonstrative therapeutic effect on DF, through their generation pro-angiogenesis factors, like vascular endothelial growth factor (VEGF).Recently, genetically modified MSCs been used in therapy and we shown depletion micoRNA-205-5p (miR-205-5p) human promotes VEGF-mediated effects DF.Here, showed long non-coding RNA...
Abstract The mevalonate pathway is known for the synthesis of cholesterol, but recent studies have reported that it also controls Hippo signaling, which critical regulation organ size and tumorigenesis. Here, we discover suppression inhibits growth proliferation colon cancer cell lines. results transcriptomic proteomic assays suggested multiple signaling pathways relevant to proliferation, were further confirmed using western blot, PCR, immunofluorescence assays. As an energy-consuming...
Dipeptidyl peptidase-4 (DPP-4) inhibitors have been considered as incretin-based agents that signal through GLP-1R. Our high-throughput RNA sequencing (RNA-seq) and bioinformatics methods indicated GLP-1R, downregulated in diabetes mellitus (DM), was a potential target of DPP-4 inhibitors, which further confirmed DM rats. Thus, this study illuminated the alleviatory mechanism on cognitive dysfunction may be associated with GLP-1R signaling. rats were administered Chloroquine (an autophagy...
The interaction between advanced glycation end products and their cellular receptor (RAGE) has an important role in the pathogenesis of diabetic microvascular complications. aim this study was to investigate relationship 2184A/G polymorphism RAGE gene nephropathy Chinese Han patients with type 2 diabetes mellitus. A total 868 mellitus (486 without 382 nephropathy) were enrolled study. genotype allele frequencies detected using polymerase chain reaction-restriction fragment-length method. G...
Persistent immune activation during chronic human immunodeficiency virus type 1 (HIV-1) infection facilitates dysfunction and thereby fuels disease progression. The translocation of bacterial derivatives into blood the hyperinflammatory responsiveness monocytes have been considered important causative factors for persistent activation. Whether microRNAs (miRNAs) are involved in regulating monocyte-mediated inflammatory responses HIV-1 remains elusive. In this study, we show that miR-126-5p...
BackgroundDiesel exhaust [diesel particles (DEPs) and their extracts (DPE)] ultraviolet A radiation (UVA) are two ubiquitous environmental factors that have been identified as essential risk for various benign or malignant human diseases, either alone in combination with other agents.ObjectivesWe aimed to investigate the synergistic effects of DPE UVA at low-dose exposures human–hamster hybrid (AL) cells underlying mechanisms.MethodsWe exposed exponentially growing AL and/or without reactive...
Diabetes is a prevalent disease endangering human health, while diabetic foot (DF) one of the most severe complications diabetes. Mesenchymal stem cells (MSCs) have been used in DF treatment, taking advantage differentiation potential MSCs into endothelial and their production secretion trophic factors like vascular growth factor (VEGF). Molecular modification to improve therapeutic effects has recently applied treating other diseases, but not yet DF. Here, we found that micoRNA-205-5p...
Cardiomyocytes hypertrophy and apoptosis induced by advanced glycation end products (AGEs) is the crucial pathological foundation contributing to onset development of diabetic cardiomyopathy (DCM). However, mechanism remains poorly understood. Here, we report that profilin-1 (PFN-1), a well-known actin-binding protein, serves as potent regulator in AGEs-induced cardiomyocytes apoptosis. PFN-1 was upregulated AGEs-treated H9c2 cells, which associated with increased Silencing expression...
To elucidate the mechanism of how liver participates in PM2.5-caused insulin resistance. A novel Wistar rat model was developed this study by instilling a suspension lyophilized PM2.5 sample (2.5 mg/kg, 5 or 10 mg/kg) collected from atmosphere. Systemic resistance indicators, including serum fasting blood glucose (FBG), (FINS), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), and hemoglobin A1 (HbA1), were upregulated instillation. The area under curve (AUCglu) calculated...
Cyclic GMP-AMP synthase (cGAS) recognizes Y-form cDNA of human immunodeficiency virus type 1 (HIV-1) and initiates antiviral immune response through cGAS-stimulator interferon genes (STING)-TBK1-IRF3-type I (IFN-I) signalingcascade. Here, we report that the HIV-1 p6 protein suppresses HIV-1-stimulated expression IFN-I promotes evasion. Mechanistically, glutamylated at residue Glu6 inhibits interaction between STING tripartite motif 32 (TRIM32) or autocrine motility factor receptor (AMFR)....
Abstract Aim Diabetic foot has become the main cause of non-traumatic amputation. Stem cell therapy, especially mesenchymal stem cells (MSCs), holds a great promise as therapy for diabetic with ischemia limb arterial disease. The aim this pilot study is to evaluate safety and efficacy placenta-derived MSCs (P-MSCs) treatment patients critical (CLI). Methods Four eligible CLI were consecutively enrolled in study. On base standard-of-care treatment, these accepted P-MSCs by intramuscular...
Insulin secretion from pancreatic β‑cells regulates glucose metabolism and is related to various diseases including diabetes. The late endosomal/lysosomal adaptor MAPK mTOR activator 1 (LAMTOR1) one of the subunits ‘Ragulator’ complex plays an important role in energy metabolism. present study was designed explore LAMTOR1 murine β‑cell function. A model with β cell‑specific deficiency (βLamtor1‑KO) generated assess function (insulin sensitivity paired responses) by hyperglycemic clamp vivo....