A5049874803- Immune Response and Inflammation
- interferon and immune responses
- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- Escherichia coli research studies
- Antimicrobial Resistance in Staphylococcus
- Immunotherapy and Immune Responses
- RNA regulation and disease
- T-cell and B-cell Immunology
- Immune cells in cancer
- HIV Research and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Galectins and Cancer Biology
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
- Melanoma and MAPK Pathways
- Viral Infections and Vectors
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Atrial Fibrillation Management and Outcomes
- Metal-Organic Frameworks: Synthesis and Applications
- SARS-CoV-2 and COVID-19 Research
- Fibroblast Growth Factor Research
- Probiotics and Fermented Foods
- Covalent Organic Framework Applications
Fudan University
2016-2024
Zhongshan Hospital of Xiamen University
2024
Beijing Institute of Technology
2024
Shanghai Public Health Clinical Center
2019-2023
Army Medical University
2018-2022
Army Medical College
2022
Southwest Jiaotong University
2022
Sichuan University
2022
Shanghai Medical College of Fudan University
2018
Shanghai Institutes for Biological Sciences
2008-2016
Abstract In the event of a public health crisis, highly effective and sustainable antimicrobial materials equipment will be urgently needed. Here, preparation is reported by electrospinning broad‐spectrum antibacterial nanofibers embedded in photoactive hydrogen‐bonded organic framework (HOF) rod‐like nanocrystals ≈60 nm length. The resulting HOF@PVDF‐HFP maintain excellent tensile breathability characteristics while shielding HOF against acid alkali corrosion. A series with different...
Abstract Macrophages are important innate immune defense system cells in the fight against bacterial and fungal pathogenic infections. They exhibit significant plasticity, particularly with their ability to undergo functional differentiation. Additionally, HIF1α is critically involved differentiation of macrophages during inflammation. However, role macrophage protecting different infections remains unclear. In this study, we investigated compared roles effects vitro vivo . We found that...
Macrophages are the key regulator of T-cell responses depending on their activation state. C-C motif chemokine receptor-like 2 (CCRL2), a nonsignaling atypical receptor originally cloned from LPS-activated macrophages, has recently been shown to regulate immune under several inflammatory conditions. However, whether CCRL2 influences macrophage function and regulates tumor immunity remains unknown. Here, we found that tumoral expression is predictive indicator robust antitumor in human...
Significance The homeostasis of FoxP3 + Treg cells, essential controllers immune and autoimmune responses, integrates inputs from the antigen-specific T-cell receptor (TCR) trophic cytokines or chemotactic cues. Expanding upon previous indications that cells might be hyporesponsive, we find TCR triggering induces dampened responses along all tested pathways in compared with conventional CD4 T whereas their to IFN-I, IL6, IL2 were equal stronger. This imbalance indicates are less sensitive...
Pulmonary infection is the most common risk factor for acute lung injury (ALI). Innate immune responses induced by Microbe-Associated Molecular Pattern (MAMP) molecules are essential defense but can lead to tissue injury. Little known about how MAMP degraded in or degradation/inactivation helps prevent ameliorate harmful inflammation that produces ALI. Acyloxyacyl hydrolase (AOAH) a host lipase inactivates Gram-negative bacterial endotoxin (lipopolysaccharide, LPS). We report here alveolar...
Abstract Virus infection may induce excessive interferon (IFN) responses that can lead to host tissue injury or even death. β-arrestin 2 regulates multiple cellular events through the G protein-coupled receptor (GPCR) signaling pathways. Here we demonstrate also promotes virus-induced production of IFN-β and clearance viruses in macrophages. interacts with cyclic GMP-AMP synthase (cGAS) increases binding dsDNA cGAS enhance (cGAMP) downstream stimulator genes (STING) innate immune responses....
Immune responses to pathogens are regulated by immune receptors containing either an immunoreceptor tyrosine-based activation motif (ITAM) or inhibitory (ITIM). The important diarrheal pathogen enteropathogenic Escherichia coli (EPEC) require delivery and insertion of the bacterial translocated intimin receptor (Tir) into host plasma membrane for pedestal formation. C-terminal region Tir, encompassing Y483 Y511, shares sequence similarity with cellular ITIMs. Here, we show that EPEC Tir...
Tuberculosis, caused by Mycobacterium tuberculosis infection, remains a global threat to human health, but knowledge of the molecular mechanisms underlying pathogenesis is still limited. Although Notch4, member Notch receptor family, involved in initiation mammary tumors, its function M. infection unclear. In this study, we found that Notch4-deficient mice were more resistant with much lower bacterial burden and fewer pathological changes lungs. Notch4 inhibited tuberculosis-induced...
Abstract Many pathogens secrete effectors to hijack intracellular signaling regulators in host immune cells promote pathogenesis. However, the pathogenesis of Staphylococcus aureus secretory within is unclear. Here, we report that secretes extracellular fibrinogen-binding protein (Efb) into cytoplasm macrophages suppress immunity. Mechanistically, RING finger 114, a E3 ligase, mediates K27-linked ubiquitination Efb at lysine 71, which facilitates recruitment tumor necrosis factor receptor...
Abstract Excessive or uncontrolled release of proinflammatory cytokines caused by severe viral infections often results in host tissue injury even death. Phospholipase C (PLC)s degrade phosphatidylinositol-4, 5-bisphosphate (PI(4,5)P2) lipids and regulate multiple cellular events. Here, we report that PLCβ2 inhibits the virus-induced expression pro-inflammatory interacting with inhibiting transforming growth factor-β-activated kinase 1 (TAK1) activation. Mechanistically, PI(4,5)P2 directly...
Cyclic GMP-AMP synthase (cGAS) recognizes Y-form cDNA of human immunodeficiency virus type 1 (HIV-1) and initiates antiviral immune response through cGAS-stimulator interferon genes (STING)-TBK1-IRF3-type I (IFN-I) signalingcascade. Here, we report that the HIV-1 p6 protein suppresses HIV-1-stimulated expression IFN-I promotes evasion. Mechanistically, glutamylated at residue Glu6 inhibits interaction between STING tripartite motif 32 (TRIM32) or autocrine motility factor receptor (AMFR)....
Many pathogens infect hosts through various immune evasion strategies. However, the molecular mechanisms by which pathogen proteins modulate and evade host response remain unclear. Enterohemorrhagic Escherichia coli (EHEC) is a pathological strain that can induce mitogen-activated protein (MAP) kinase (Erk, Jnk p38 MAPK) NF-κB pathway activation proinflammatory cytokine production, then causes diarrheal diseases such as hemorrhagic colitis hemolytic uremic syndrome. Transforming growth...
Abstract Helicobacter pylori is the major etiological agent for most gastric cancer. CagA has been reported to be an important virulence factor of H. pylori, but its effect on immune response not yet clear. In this study, wild-type C57BL/6 mice and Ptpn6me-v/me-v were randomly assigned infection with pylori. We demonstrated that suppressed pylori–stimulated expression proinflammatory cytokines in vivo. Besides, we infected mouse peritoneal macrophages RAW264.7 AGS Our results showed through...
SARS-COV-2 infection-induced excessive or uncontrolled cytokine storm may cause injury of host tissue even death. However, the mechanism by which causes is unknown. Here, we demonstrated that protein NSP9 promoted production interacting with and activating TANK-binding kinase-1 (TBK1). With an rVSV-NSP9 virus infection model, discovered NSP9-induced exacerbated damage death in mice. Mechanistically, K63-linked ubiquitination phosphorylation TBK1, induced activation translocation IRF3,...
Type I interferons play a pivotal role in innate immune response to virus infection. The protein tyrosine phosphatase SHP-1 was reported function as negative regulator of inflammatory cytokine production by inhibiting activation NF-κB and MAPKs during bacterial infection, however, the regulating type remains unknown. Here, we demonstrated that knockout or knockdown macrophages promoted both HSV-1- VSV-induced antiviral response. Conversely, overexpression L929 cells suppressed response;...
The protein translocated intimin receptor (Tir) from enteropathogenic Escherichia coli shares sequence similarity with the host cellular immunoreceptor tyrosine-based inhibition motifs (ITIMs). ITIMs of Tir are required for Tir-mediated immune and evasion responses. However, underlying molecular mechanism by which regulates remains unclear. Here we demonstrated that β-arrestin 2, is involved in G-protein-coupled (GPCR) signal pathway, interacted an ITIM-dependent manner. For mechanism, found...